Growth Hormone Receptor Protein (GHR) (AA 27-264) (His tag)
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Quick Overview for Growth Hormone Receptor Protein (GHR) (AA 27-264) (His tag) (ABIN2181159)
抗原
See all Growth Hormone Receptor (GHR) 蛋白蛋白类型
生物活性
宿主
资源
纯度
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产品特性
- AA 27-264
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标记
- This Growth Hormone Receptor protein is labelled with His tag.
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序列
- AA 27-264
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产品特性
- This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 28.5 kDa. The protein migrates as 40-50 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
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过滤
- 0.22 μm filtered
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内毒素水平
- Less than 1.0 EU per μg by the LAL method.
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Growth Hormone Receptor (GHR) (AA 27-264) (Active) protein (His tag)
GHR 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Bis-Tris PAGE,> 95 % as determined by HPLC Active
Growth Hormone Receptor (GHR) protein (Fc Tag)GHR 宿主: 小鼠 宿主: 人细胞 Recombinant > 95 % as determined by SDS-PAGE
Growth Hormone Receptor (GHR) (AA 27-264) (Active) protein (His-Fc tag)GHR 宿主: 人 宿主: Mammalian Cells Recombinant >90 % as determined by SDS-PAGE. SDS, WB, ELISA, Imm, AcA Active
Growth Hormone Receptor (GHR) (AA 27-264) protein (Fc Tag)GHR 宿主: 人 宿主: HEK-293 Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining. AM, ADA, IA, ScA
Growth Hormone Receptor (GHR) (Active) protein (His tag)GHR 宿主: 大鼠 宿主: HEK-293 Cells Recombinant > 95 % as determined by SDS-PAGE Active
Growth Hormone Receptor (GHR) (Active) protein (His tag,Fc Tag)GHR 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 85 % as determined by SDS-PAGE Active
Growth Hormone Receptor (GHR) (Active) protein (Fc Tag)GHR 宿主: 大鼠 宿主: HEK-293 Cells Recombinant > 95 % as determined by SDS-PAGE Active
Growth Hormone Receptor (GHR) (Active) protein (His tag)GHR 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 95 % as determined by SDS-PAGE Active
Growth Hormone Receptor (GHR) (AA 27-264) (Active) protein (Fc Tag)GHR 宿主: 人 宿主: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE. Active
Growth Hormone Receptor (GHR) (AA 19-264) (Active) protein (Fc Tag)GHR 宿主: 猕猴 宿主: HEK-293 Cells Recombinant >90 % as determined by SDS-PAGE. Active
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限制
- 仅限研究用
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状态
- Lyophilized
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缓冲液
- PBS, pH 7.4
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注意事项
- Please avoid repeated freeze-thaw cycles.
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储存条件
- -20 °C
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储存方法
- No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C), After reconstitution under sterile conditions for 3 months (-70 °C).
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: "Nanofluidic device for continuous multiparameter quality assurance of biologics." in: Nature nanotechnology, Vol. 12, Issue 8, pp. 804-812, (2019) (PubMed).
: "Mechanism of immobilized protein A binding to immunoglobulin G on nanosensor array surfaces." in: Analytical chemistry, Vol. 87, Issue 16, pp. 8186-93, (2015) (PubMed).
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: "Nanofluidic device for continuous multiparameter quality assurance of biologics." in: Nature nanotechnology, Vol. 12, Issue 8, pp. 804-812, (2019) (PubMed).
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- Growth Hormone Receptor (GHR)
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别名
- Growth Hormone R
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背景
- Growth hormone receptor (GHR) is also known as somatotropin receptor, growth hormone-binding protein (GHBR), which belongs to the type I cytokine receptor family or Type 1 subfamily. GHR contains one fibronectin type-III domain. GHR / GHBR is expressed in various tissues with high expression in liver and skeletal muscle. The soluble form (GHBP) is produced by phorbol ester-promoted proteolytic cleavage at the cell surface (shedding) by ADAM17/TACE. GHR is receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding, couples to the JAK2/STAT5 pathway. The soluble form (GHBP) acts as a reservoir of growth hormone in plasma and may be a modulator/inhibitor of GH signaling.
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分子量
- 29.6 kDa
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NCBI登录号
- NP_000154
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UniProt
- P10912
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途径
- NF-kappaB Signaling, JAK/STAT Signaling, Response to Growth Hormone Stimulus
抗原
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