IL6RA Protein (AA 20-358, Isoform 1) (His tag)
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- 抗原 See all IL6RA 蛋白
- IL6RA (Interleukin 6 Receptor, alpha (IL6RA))
- 蛋白类型
- Recombinant
- 生物活性
- Active
- 产品特性
- Isoform 1, AA 20-358
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宿主
- 人
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资源
- Insect cells (Sf9)
- 标记
- This IL6RA protein is labelled with His tag.
- 产品特性
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ED50 < 50 ng/mL, measured by the cytotoxicity assay using M1 cells in presence of 10 ng/mL of human IL-6, corresponding to a specific activity of > 2x10^4 units/mg.
AA 20-358 (isoform 1), expressed with an N-terminal Histag. - 纯度
- > 95 % by SDS-PAGE and HPLC analyses.
- 内毒素水平
- < 0.2 EU/μg, determined by LAL method.
- Top Product
- Discover our top product IL6RA 蛋白
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Interleukin 6 Receptor, alpha (IL6RA) (AA 20-365) protein (His-Avi Tag)
IL6RA 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Interleukin 6 Receptor, alpha (IL6RA) protein (His-Avi Tag,Biotin)IL6RA 宿主: 人 宿主: HEK-293 Cells Recombinant > 95% as determined by Tris-Bis PAGE,> 95% as determined by HPLC
Interleukin 6 Receptor, alpha (IL6RA) (AA 20-365) protein (Fc Tag)IL6RA 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Interleukin 6 Receptor, alpha (IL6RA) (AA 20-365) (Active) protein (His tag)IL6RA 宿主: 人 宿主: HEK-293 Cells Recombinant >92 % as determined by SDS-PAGE. Active
Interleukin 6 Receptor, alpha (IL6RA) (Active) protein (His tag,ECD)IL6RA 宿主: 大鼠 宿主: HEK-293 Cells Recombinant > 90 % as determined by SDS-PAGE Active
Interleukin 6 Receptor, alpha (IL6RA) protein (His tag)IL6RA 宿主: 小鼠 宿主: 人细胞 Recombinant >95 % as determined by reducing SDS-PAGE.
Interleukin 6 Receptor, alpha (IL6RA) protein (Fc Tag,ECD)IL6RA 宿主: 大鼠 宿主: HEK-293 Cells Recombinant > 90 % as determined by SDS-PAGE
Interleukin 6 Receptor, alpha (IL6RA) (AA 20-365) (Active) protein (Fc Tag)IL6RA 宿主: 人 宿主: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE. Active
Interleukin 6 Receptor, alpha (IL6RA) (AA 20-357) (Active) protein (His tag,AVI tag,Biotin)IL6RA 宿主: 小鼠 宿主: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE. Active
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Reconstituted in ddH2O at 100 μg/mL.
- 缓冲液
- Lyophilized after extensive dialysis against PBS.
- 储存条件
- -80 °C
- 储存方法
- Lyophilized recombinant human Soluble IL-6 Receptor Alpha (rhsIL-6R alpha) remains stable up to 6 months at -80 °C from date of receipt. Upon reconstitution, rhsIL-6R alpha remains stable up to 2 weeks at 4 °C or up to 3 months at -20 °C.
- 有效期
- 6 months
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- 抗原
- IL6RA (Interleukin 6 Receptor, alpha (IL6RA))
- Abstract
- IL6RA 产品
- 别名
- IL6R1 Protein, Il6ra Protein, CD126 Protein, IL-6R-1 Protein, IL-6RA Protein, IL6Q Protein, IL6RA Protein, IL6RQ Protein, gp80 Protein, IL-6R Protein, Il6r Protein, interleukin 6 receptor Protein, interleukin 6 receptor, alpha Protein, Il6r Protein, IL6R Protein, Il6ra Protein
- 背景
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Interleukin-6 Receptor (IL-6R) is a single trans-membrane protein that is the receptor for Interleukin-6 (IL-6). IL-6R forms a hexameric complex upon binding 2 Molecules of IL-6 and two molecules of glycoprotein 130 (gp130) which activates intracellular JAK/STAT pathways. Although the normal form of IL-6R is the membrane-bound 80 kDa subunit, a soluble form of IL-6R (sIL-6R) can be generated physiologically by limited proteolysis or alternative splicing. sIL-6R binds to both IL-6 and gp130 generating intracellular signaling. In the immune system, sIL-6R is produced by both na ve and memory CD4 T-cells and strongly augments IL-6 ligand's induction of Th-17 cells.Recombinant human Soluble IL-6 Receptor Alpha (rhsIL-6R alpha) with an N-terminal His tag produced in Sf9 insect cells is a single glycosylated polypeptide chain containing 350 amino acids. A fully biologically active molecule, rhsIL-6R alpha has a molecular mass of 50 kDa analyzed by reducing SDS-PAGE.
Synonyms: gp80 - 分子量
- 50 kDa, observed by reducing SDS-PAGE.
- UniProt
- P08887
- 途径
- JAK/STAT Signaling, Autophagy, Growth Factor Binding, Cancer Immune Checkpoints
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