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IL6RA Protein (AA 20-365) (His tag)

IL6RA 宿主: 人 宿主: HEK-293 Cells Recombinant >92 % as determined by SDS-PAGE. Active
产品编号 ABIN2181394
发货至: 中国
  • 抗原 See all IL6RA 蛋白
    IL6RA (Interleukin 6 Receptor, alpha (IL6RA))
    蛋白类型
    Recombinant
    生物活性
    Active
    产品特性
    AA 20-365
    宿主
    • 15
    • 5
    • 3
    • 1
    资源
    • 15
    • 3
    • 2
    • 2
    • 1
    HEK-293 Cells
    标记
    This IL6RA protein is labelled with His tag.
    序列
    AA 20-365
    产品特性
    This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 40 kDa. The protein migrates as 60-70 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
    纯度
    >92 % as determined by SDS-PAGE.
    过滤
    0.22 μm filtered
    内毒素水平
    Less than 1.0 EU per μg by the LAL method.
    Top Product
    Discover our top product IL6RA 蛋白
  • 限制
    仅限研究用
  • 状态
    Lyophilized
    缓冲液
    PBS, pH 7.4
    注意事项
    Please avoid repeated freeze-thaw cycles.
    储存条件
    -20 °C
    储存方法
    No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C), After reconstitution under sterile conditions for 3 months (-70 °C).
  • Tanemura, Mochizuki, Kumachi, Nemoto: "Easy and rapid binding assay for functional analysis of disulfide-containing peptides by a pull-down method using a puromycin-linker and a cell-free translation system." in: Biology, Vol. 4, Issue 1, pp. 161-72, (2015) (PubMed).

  • 抗原
    IL6RA (Interleukin 6 Receptor, alpha (IL6RA))
    别名
    IL-6 R alpha (IL6RA 产品)
    别名
    IL6R1 Protein, Il6ra Protein, CD126 Protein, IL-6R-1 Protein, IL-6RA Protein, IL6Q Protein, IL6RA Protein, IL6RQ Protein, gp80 Protein, IL-6R Protein, Il6r Protein, interleukin 6 receptor Protein, interleukin 6 receptor, alpha Protein, Il6r Protein, IL6R Protein, Il6ra Protein
    背景
    Interleukin 6 receptor (IL6R) is also known as CD126 (Cluster of Differentiation 126) , is a potent pleiotropic cytokine that regulates cell growth and differentiation of various tissues, and is known particularly for its role in the immune response and acute phase reactions. IL6R is a protein complex consisting of a IL-6 receptor subunit (IL6R) and interleukin 6 signal transducer Glycoprotein 130. IL6R also denotes the human gene encoding this subunit. Alternatively spliced transcript variants encoding distinct isoforms have been reported. IL6R subunit also shared by many other cytokines. The soluble form of IL6R arises from proteolytic cleavage of membrane-bound IL6Rα, and acts agonistically by making the IL6 ligand accessible to the signal transducer gp130. Dysregulated production of IL6 and IL6R are implicated in the pathogenesis of several inflammatory diseases and malignancies such as multiple myeloma, rheumatoid arthritis, or osteoporosis, and it has been reported that a humanized anti-IL6R monoclonal antibody is a promising agent applicable to the therapeutic approach for IL6 driven diseases. Interleukin-6 receptor has been shown to interact with Interleukin 6 and Ciliary neurotrophic factor.
    分子量
    39.4 kDa
    NCBI登录号
    NP_000556
    途径
    JAK/STAT Signaling, Autophagy, Growth Factor Binding, Cancer Immune Checkpoints
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