IL6RA Protein (His tag,ECD)
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- 抗原 See all IL6RA 蛋白
- IL6RA (Interleukin 6 Receptor, alpha (IL6RA))
- 蛋白类型
- Recombinant
- 生物活性
- Active
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宿主
- 大鼠
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资源
- HEK-293 Cells
- 标记
- This IL6RA protein is labelled with His tag,ECD.
- 原理
- Recombinant Rat IL6RA/CD126 Protein (ECD, His Tag)(Active)
- 序列
- Met1-Pro364
- 产品特性
- A DNA sequence encoding the rat Il6r (NP_058716.2) (Met1-Pro364) was expressed with a polyhistidine tag at the C-terminus.
- 纯度
- > 90 % as determined by SDS-PAGE
- 内毒素水平
- < 1.0 EU per μg protein as determined by the LAL method.
- Biological Activity Comment
- Measured by its ability to bind human IL6 in functional ELISA.
- Top Product
- Discover our top product IL6RA 蛋白
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Interleukin 6 Receptor, alpha (IL6RA) (AA 20-365) protein (His-Avi Tag)
IL6RA 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Interleukin 6 Receptor, alpha (IL6RA) protein (His-Avi Tag,Biotin)IL6RA 宿主: 人 宿主: HEK-293 Cells Recombinant > 95% as determined by Tris-Bis PAGE,> 95% as determined by HPLC
Interleukin 6 Receptor, alpha (IL6RA) (AA 20-365) protein (Fc Tag)IL6RA 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Interleukin 6 Receptor, alpha (IL6RA) (AA 20-365) (Active) protein (His tag)IL6RA 宿主: 人 宿主: HEK-293 Cells Recombinant >92 % as determined by SDS-PAGE. Active
Interleukin 6 Receptor, alpha (IL6RA) protein (His tag)IL6RA 宿主: 小鼠 宿主: 人细胞 Recombinant >95 % as determined by reducing SDS-PAGE.
Interleukin 6 Receptor, alpha (IL6RA) protein (Fc Tag,ECD)IL6RA 宿主: 大鼠 宿主: HEK-293 Cells Recombinant > 90 % as determined by SDS-PAGE
Interleukin 6 Receptor, alpha (IL6RA) (AA 20-364) protein (His tag)Crystallography grade IL6RA 宿主: 小鼠 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. ELISA, WB, Crys, SDS
Interleukin 6 Receptor, alpha (IL6RA) (AA 20-460) protein (rho-1D4 tag)Crystallography grade IL6RA 宿主: 小鼠 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. ELISA, WB, Crys, SDS
Interleukin 6 Receptor, alpha (IL6RA) (AA 20-365) (Active) protein (Fc Tag)IL6RA 宿主: 人 宿主: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE. Active
Interleukin 6 Receptor, alpha (IL6RA) (AA 20-357) (Active) protein (His tag,AVI tag,Biotin)IL6RA 宿主: 小鼠 宿主: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE. Active
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Please refer to the printed manual for detailed information.
- 缓冲液
- Lyophilized from sterile PBS, pH 7.4
- 储存条件
- 4 °C,-20 °C,-80 °C
- 储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- 抗原
- IL6RA (Interleukin 6 Receptor, alpha (IL6RA))
- 别名
- IL6RA/CD126 (IL6RA 产品)
- 别名
- IL6R1 Protein, Il6ra Protein, CD126 Protein, IL-6R-1 Protein, IL-6RA Protein, IL6Q Protein, IL6RA Protein, IL6RQ Protein, gp80 Protein, IL-6R Protein, Il6r Protein, interleukin 6 receptor Protein, interleukin 6 receptor, alpha Protein, Il6r Protein, IL6R Protein, Il6ra Protein
- 背景
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Background: Interleukin 6 receptor (IL-6R) also known as CD126 (Cluster of Differentiation 126) is a type I cytokine receptor. The low concentration of a soluble form of IL-6 receptor (sIL-6R) acts as an agonist of IL-6 activity. In the IL-6R/CD126/IL6R system, both a membrane-bound IL-6R and a sIL-6R protein are able to mediate IL-6 signals into the cells through the interaction of gp130. The resulting IL-6/sIL-6R protein complex is also capable of binding to gp130 and inducing intracellular signalling. Through this so-called 'trans-signalling' mechanism, IL-6 is able to stimulate cells that lack an endogenous mIL-6R. High levels of IL-6 and sIL-6R have been reported in several chronic inflammatory and autoimmune diseases as well as in cancer.Immune Checkpoint Immunotherapy Cancer Immunotherapy Targeted Therapy
Synonym: Il6ra;IL-6R
- 分子量
- 39.5 kDa
- NCBI登录号
- NP_058716
- 途径
- JAK/STAT Signaling, Autophagy, Growth Factor Binding, Cancer Immune Checkpoints
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