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Human CDKN1A Protein expressed in HEK-293 Cells - ABIN2713874
Porter, Farmaki, Altilia, Schools, West, Chen, Chang, Puzyrev, Lim, Rokow-Kittell, Friedhoff, Papavassiliou, Kalurupalle, Hurteau, Shi, Baran, Gyorffy, Wentland, Broude, Kiaris, Roninson: Cyclin-dependent kinase 8 mediates chemotherapy-induced tumor-promoting paracrine activities. in Proceedings of the National Academy of Sciences of the United States of America 2012
We characterized the effect of the novel loci through pathway analysis and found that pathways involved are not entirely distinct as assumed so far. Further, we identified a novel association between CDKN1A and POAG. Using a zebrafish model we show that six6b (associated with POAG and optic nerve head variation) alters the expression of cdkn1a
intestinal clock controls the expression of key cell cycle regulators, such as cdc2 (显示 CDK1 蛋白), wee1 (显示 WEE1 蛋白), p21, PCNA (显示 PCNA 蛋白) and cdk2 (显示 CDK2 蛋白), but only weakly influences cyclin B1 (显示 CCNB1 蛋白), cyclin B2 (显示 CCNB2 蛋白) and cyclin E1 (显示 CCNE1 蛋白) expression.
Polymorphisms in TP53 (显示 TP53 蛋白) and P21 proteins are associated with an increased risk of stomach cancer.
A chimeric cDNA construct of human p53 (显示 TP53 蛋白) was made where the 1-260 bp N-terminus was replaced with buffalo p53 (显示 TP53 蛋白) counterpart and expressed in H1299 cell line. The tetramerization ability of the chimeric p53 (显示 TP53 蛋白) protein was comparable to that of h-p53 (显示 TP53 蛋白). Properties of b-p53 (显示 TP53 蛋白) like stronger p21 transactivation and super sensitivity to Mdm2 (显示 MDM2 蛋白) mediated degradation were lacking in the chimeric protein.
These findings suggested that the ATM (显示 ATM 蛋白)/p21 pathway directly participated in the LDIR-induced cell proliferation inhibition in p53null type prostate tumor cells, whereas this mechanism was absent in normal prostate cells. Thus, p53 (显示 TP53 蛋白) may affect cell stability following LDIR, and plays a crucial role in regulating the ATM (显示 ATM 蛋白)/p21 pathway activated by LDIR.
The associated effects appear to be mediated by inhibition of IGFBP-2 expression and stimulation of p21 expression. This suggests that simulated microgravity might represent a promising method to discover new targets for glioma therapeutic strategy.
variants of EGFR (显示 EGFR 蛋白) and SYNE2 (显示 SYNE2 蛋白) play an important role in p21 regulation and are associated with the clinical outcome of HBV-related hepatocellular carcinoma in a TP53 (显示 TP53 蛋白)-indenpdent manner
GRh2 dose-dependently inhibited prostate cancer cell proliferation, but did not alter cell apoptosis, seemingly through downregulation of miR (显示 MLXIP 蛋白)-4295, which inhibits protein translation of CDKN1A.
Increased baseline gene expressions of RUNX2 (显示 RUNX2 蛋白), p21 and caspase 3 (显示 CASP3 蛋白) in the peripheral blood might predict better responses to methotrexate therapy.
These results demonstrate that miR (显示 MLXIP 蛋白)-95-3p is a potential new marker for Hepatocellular carcinoma and regulates hepatocarcinogenesis by directly targeting CDKN1A/p21 expression.
rescue experiments indicated that SNHG20 functioned as an oncogene (显示 RAB1A 蛋白) partly via repressing p21 in non-small cell lung cancer (NSCLC) cells. Taken together, our findings demonstrate that SNHG20 is a new candidate for use in NSCLC diagnosis, prognosis and therapy.
Expression of CIP/KIP (显示 CIB1 蛋白) proteins was found abundantly within the proliferative hair matrix, concomitant with a role in cell cycle checkpoint control. p21(CIP1), p27(KIP1 (显示 CDKN1B 蛋白)) and cyclin E (显示 CCNE1 蛋白) persisted within post-mitotic keratinocytes of the pre-cortex, whereas p57(KIP2 (显示 CDKN1C 蛋白)) protein decreased but became nuclear.
p21 expression reports on Bovine herpesvirus 4 replication and could represent a host cell defensive response to infection-associated cellular damage.
while muCT analysis indicates that p21(-/-) mice have enhanced bone healing capabilities, differences observed may not be due to the function of osteoblasts or osteoclasts
the deletion of Cdkn1a in vivo results in an elevated level of cell proliferation but not cell death.
p21 plays a relevant role in fasting adaptation through the positive regulation of PPARalpha (显示 PPARA 蛋白).
The results suggested that TAZ (显示 TAZ 蛋白) may suppress apoptosis and premature senescence in spermatogenic cells by inhibiting the p53 (显示 TP53 蛋白)-p21 signaling pathway, thus playing important roles in the maintenance and control of reproductive function.
Results identify endoplasmic reticulum stress as an age-dependent modifier of islet survival and function by mechanisms implicating enhancement of CHOP (显示 DDIT3 蛋白) activity and inhibition of the protective activity of p21.
Specifically, the proteins p18INK4C (显示 CDKN2C 蛋白), p21CIP1 and p27KIP1 (显示 CDKN1B 蛋白) seem to play an outstanding role in the maintenance of the differentiated state of adipocytes.
Collectively, our findings demonstrate that PCAT-1 is a new candidate for use in OS diagnosis, prognosis and therapy.
results indicated that p21-deficient DMM (显示 COL2A1 蛋白) mice were susceptible to alterations in Osteoarthritis (OA) phenotype, including enhanced osteoclast expression, macrophage infiltration, and MMP expression through IL-1beta (显示 IL1B 蛋白)-induced NF-kappaB (显示 NFKB1 蛋白) signaling, suggesting that p21 regulation may constitute a possible therapeutic strategy for OA treatment.
our genetic and biochemical data show an important function of p21 in the regulation of growth-related processes in the heart.
The Smad3 (显示 SMAD3 蛋白) and Bmal1 (显示 ARNTL 蛋白) regulate p21 and S100A4 (显示 S100A4 蛋白) expression in myocardial stromal fibroblasts through TNF-alpha (显示 TNF 蛋白).
This gene encodes a potent cyclin-dependent kinase inhibitor. The encoded protein binds to and inhibits the activity of cyclin-CDK2 or -CDK4 complexes, and thus functions as a regulator of cell cycle progression at G1. The expression of this gene is tightly controlled by the tumor suppressor protein p53, through which this protein mediates the p53-dependent cell cycle G1 phase arrest in response to a variety of stress stimuli. This protein can interact with proliferating cell nuclear antigen (PCNA), a DNA polymerase accessory factor, and plays a regulatory role in S phase DNA replication and DNA damage repair. This protein was reported to be specifically cleaved by CASP3-like caspases, which thus leads to a dramatic activation of CDK2, and may be instrumental in the execution of apoptosis following caspase activation. Multiple alternatively spliced variants have been found for this gene.
cyclin dependent kinase inhibitor p16Xic2
, cyclin-dependent kinase inhibitor 1
, cyclin D1
, cyclin-dependent kinase inhibitor 1A (p21, Cip1)
, cyclin-dependent kinase inhibitor 1A
, cyclin-dependent kinase inhibitor 1A (P21)
, CDK-interacting protein 1
, CDK-interaction protein 1
, DNA synthesis inhibitor
, melanoma differentiation associated protein 6
, wild-type p53-activated fragment 1
, melanoma differentiation-associated protein