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抗Human LRP2 抗体:
抗Mouse (Murine) LRP2 抗体:
抗Rat (Rattus) LRP2 抗体:
Human Monoclonal LRP2 Primary Antibody for ICC, IHC (fro) - ABIN410077
Chang, Ohse, Krofft, Wu, Eddy, Pippin, Shankland: Albumin-induced apoptosis of glomerular parietal epithelial cells is modulated by extracellular signal-regulated kinase 1/2. in Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2012
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Human Polyclonal LRP2 Primary Antibody for IF (p), IHC (p) - ABIN750988
Jayachandran, Lugo, Heiling, Miller, Rule, Lieske: Extracellular vesicles in urine of women with but not without kidney stones manifest patterns similar to men: a case control study. in Biology of sex differences 2015
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Human Polyclonal LRP2 Primary Antibody for IHC (p), IHC - ABIN315066
Thelen, Abouhamed, Ciarimboli, Edemir, Bähler: Rho GAP myosin IXa is a regulator of kidney tubule function. in American journal of physiology. Renal physiology 2015
Human Polyclonal LRP2 Primary Antibody for IHC, IHC (p) - ABIN4331524
Ma, Corsa, Zhou, Yang, Li, Tang, Babaev, Major, Linton, Fazio, Hunley, Kon, Fogo: Angiotensin type 1 receptor modulates macrophage polarization and renal injury in obesity. in American journal of physiology. Renal physiology 2011
Loss of Lrp2 in zebrafish disrupts pronephric tubular clearance but not forebrain development.
These studies implicate altered Lrp2-mediated homeostasis as important for myopia and other risk factors for glaucoma.
Megalin mediates transepithelial albumin (显示 ALB 抗体) clearance from the alveolar space of intact rabbit lungs
low-level LPS (显示 IRF6 抗体)-mediated TNF-alpha (显示 TNF 抗体)-ERK1/2 signaling pathway is involved in downregulation of megalin expression in IRPTCs.
megalin is critical for mitochondrial biology; mitochondrial intracrine signaling is a continuum of the retrograde early endosome-to-Golgi-Rab32 (显示 RAB32 抗体) pathway and defects in this pathway may underlie disease processes in many systems.
patients with OCRL-1 (显示 OCRL 抗体) mutations or type 1 Dent disease showed abnormally low levels of urinary A-megalin
An Emerging Role for Megalin as a Regulator of Protein Leak in Acute Lung Injury.
Review of LRP2 function. LRP2 functions are crucial for developmental processes in a number of tissues, including the brain, the eye, and the heart, and defects in this receptor pathway are the cause of devastating congenital diseases in humans.
A novel LRP2 missense variant rs17848169 (N2632D) was found to be associated with lower risk for T2D-ESRD in this population.
we discovered one novel locus (LRP2; most significant single nucleotide polymorphism rs12988804) that reached genome-wide significance in predicting relapse risk (HR=2.18, p=3.30x10(-8)).
miR (显示 MLXIP 抗体)-148b directly down-regulates renal megalin expression.
Exocytosis-mediated urinary C-megalin excretion is associated with the development and progression of diabetic nephropathy in T2DM, particularly due to megalin-mediated lysosomal dysfunction in proximal tubules.
The studies suggest that impaired endocytosis of megalin/cubilin (显示 CUBN 抗体) ligands, hemoglobin (显示 HBB 抗体) and albumin (显示 ALB 抗体), rather than heme toxicity, may be the cause of tubular proteinuria in sickle cell disease patients.
VDR (显示 CYP27B1 抗体) and MEGALIN gene variations can alter age-related cognitive trajectories differentially between men and women among African American urban adults, specifically in global mental status and domains of verbal fluency, visual/working memory, and executive function.
TTR (显示 TTR 抗体) neuritogenic activity is mediated by the megalin receptor and is lost in megalin-deficient neurons.
in a bleomycin-based model of acute lung injury, megalin(+/-) animals (the megalin(-/-) variant is lethal due to postnatal respiratory failure) showed a marked increase in intra-alveolar protein and more severe lung injury compared with wild-type littermates
Cell type-specific glycoforms of megalin exist in the proximal tubular cells and modulate ligand absorption capacity.
This study evaluated the role of transcobalamin (TC), the transcobalamin receptor (CD320 (显示 CD320 抗体)) , and megalin in various tissues during pregnancy.
miR (显示 MLXIP 抗体)-148b negatively regulates megalin expression in unilateral ureteral obstruction-induced kidney injury.
study reveals a cross talk between ATR (显示 ATR 抗体) signaling and DPP4 (显示 DPP4 抗体) activation in the regulation of megalin and underscores the significance of targeting DPP4 (显示 DPP4 抗体) in the prevention of obesity related kidney injury progression.
LRP2 plays a crucial role in cardiovascular development in mice.
Foxg1 (显示 FOXG1 抗体)-Cre mediated Lrp2 inactivation in developing mouse neural retina, ciliary and retinal pigment epithelia is a model of congenital high myopia
The protein encoded by this gene, low density lipoprotein-related protein 2 (LRP2) or megalin, is a multi-ligand endocytic receptor that is expressed in many different tissues but primarily in absorptive epithilial tissues such as the kidney. This glycoprotein has a large amino-terminal extracellular domain, a single transmembrane domain, and a short carboxy-terminal cytoplasmic tail. The extracellular ligand-binding-domains bind diverse macromolecules including albumin, apolipoproteins B and E, and lipoprotein lipase. The LRP2 protein is critical for the reuptake of numerous ligands, including lipoproteins, sterols, vitamin-binding proteins, and hormones. This protein also has a role in cell-signaling\; extracellular ligands include parathyroid horomones and the morphogen sonic hedgehog while cytosolic ligands include MAP kinase scaffold proteins and JNK interacting proteins. Recycling of this membrane receptor is regulated by phosphorylation of its cytoplasmic domain. Mutations in this gene cause Donnai-Barrow syndrome (DBS) and facio-oculoacoustico-renal syndrome (FOAR).
low density lipoprotein-related protein 2
, low-density lipoprotein receptor-related protein 2
, low density lipoprotein receptor-related protein 2
, low-density lipoprotein receptor-related protein 2-like
, Heymann nephritis antigen homolog
, calcium sensor protein
, glycoprotein 330