Use your antibodies-online credentials, if available.
抗Human Caspase 1 抗体:
抗Mouse (Murine) Caspase 1 抗体:
抗Rat (Rattus) Caspase 1 抗体:
Human Monoclonal Caspase 1 Primary Antibody for IHC, IHC (p) - ABIN252521
Dorfleutner, Bryan, Talbott, Funya, Rellick, Reed, Shi, Rojanasakul, Flynn, Stehlik: Cellular pyrin domain-only protein 2 is a candidate regulator of inflammasome activation. in Infection and immunity 2007
Show all 26 Pubmed References
Human Polyclonal Caspase 1 Primary Antibody for IHC (p), WB - ABIN3043221
Xu, Liu, Zhang, Wang, Wang, Yang, Huo, Sun: Apoptosis-related protein expression in rabbits with blast brain injury following early hyperbaric oxygen therapy. in Neural regeneration research 2015
Show all 21 Pubmed References
Human Polyclonal Caspase 1 Primary Antibody for IHC (p), WB - ABIN3044293
Huang, Huang, Xiao, Yang, Lin, Diao: Kallistatin, a novel anti-angiogenesis agent, inhibits angiogenesis via inhibition of the NF-?B signaling pathway. in Biomedicine & pharmacotherapy = Biome?decine & pharmacothe?rapie 2014
Show all 21 Pubmed References
Mouse (Murine) Polyclonal Caspase 1 Primary Antibody for WB - ABIN5518669
Mao, Song, Li, Lv, Zhao, Li, Feng, Chen: 8-hydroxy-2-(di-n-propylamino)tetralin intervenes with neural cell apoptosis following diffuse axonal injury. in Neural regeneration research 2014
Show all 21 Pubmed References
Human Polyclonal Caspase 1 Primary Antibody for ICC, IF - ABIN4288002
Draganov, Gopalakrishna-Pillai, Chen, Zuckerman, Moeller, Wang, Ann, Lee: Modulation of P2X4/P2X7/Pannexin-1 sensitivity to extracellular ATP via Ivermectin induces a non-apoptotic and inflammatory form of cancer cell death. in Scientific reports 2015
Show all 5 Pubmed References
Human Polyclonal Caspase 1 Primary Antibody for IF, IP - ABIN222877
Peluffo, Bussmann, Stouffer, Tesone: Expression of caspase-2, -3, -8 and -9 proteins and enzyme activity in the corpus luteum of the rat at different stages during the natural estrous cycle. in Reproduction (Cambridge, England) 2006
Show all 5 Pubmed References
Human Monoclonal Caspase 1 Primary Antibody for IHC (p), ELISA - ABIN560170
Choi, Stottmann, Yang, Meyers, Klingensmith: The bone morphogenetic protein antagonist noggin regulates mammalian cardiac morphogenesis. in Circulation research 2007
Show all 2 Pubmed References
Human Polyclonal Caspase 1 Primary Antibody for IHC, IHC (p) - ABIN4287999
Dumas, Amiable, de Rivero Vaccari, Chae, Keane, Lacroix, Vallières: The inflammasome pyrin contributes to pertussis toxin-induced IL-1β synthesis, neutrophil intravascular crawling and autoimmune encephalomyelitis. in PLoS pathogens 2014
Human Polyclonal Caspase 1 Primary Antibody for ICC, IF - ABIN4288006
Kariya, Okano, Zhao, Kataoka, Yoshinobu, Maeda, Ishihara, Higaki, Nishizaki: Activation of NLRP3 inflammasome in human middle ear cholesteatoma and chronic otitis media. in Acta oto-laryngologica 2016
The increased expression of NLRP3 (显示 NLRP3 抗体) and caspase-1 in fetal membrane and placental tissues may be associated with the development of premature rupture of membrane.
inflammasome activation and pyroptosis in human microglia and ODCs in vitro after exposure to inflammatory stimuli and demonstrate caspase-1 inhibition by the small-molecule inhibitor VX-765 in both cell types. GSDMD (显示 GSDMD 抗体) inhibition by siRNA transduction suppressed pyroptosis in human microglia.
Increased production of caspase-1 in the gut (显示 GUSB 抗体)-associated lymphoid tissue and peripheral blood of HIV infected patients.
Low CASP1 expression is associated with prostate cancer.
These findings confirm the involvement of caspase-1 in non-classical secretion mechanisms and open novel perspectives for the extracellular function of secreted GBP-1 (显示 GBP1 抗体).
this study demonstrates that the G+7/in6A and A10370-G polymorphisms of the CASP1 gene are associated with increased risk of developing acute coronary syndrome in Mexican population
After genotype calling and quality control filtering with exclusion of 3 cases and 3 controls, association analysis was performed across 76 directly genotyped SNPs in NLRP1 (显示 NLRP1 抗体), CARD, and CASP1 genes, adjusting for age, sex, and population stratification
Caspase-1 role in pyroptosis in glioma cells.Mir-214 regulates caspase-1 expression in glioma.
Data show that cyclic stretch activated the nucleotide-binding oligomerization domain-like receptor containing pyrin (显示 MEFV 抗体) domain 1 and 3 (NLRP1 (显示 NLRP1 抗体) and NLRP3 (显示 NLRP3 抗体)) inflammasomes and induced the release of IL-1beta (显示 IL1B 抗体) and pyroptosis via a caspase-1-related mechanism in human periodontal ligament cells (HPDLCs).
Caspase-1 directly cleaves alpha-Synuclein, generating a highly aggregation-prone species in neurons.
The enzymatic activities of caspase-1 and caspase-11 (显示 CASP4 抗体) are required for growth inhibition in different cell types.These results reveal that these proteases have important functions beyond the direct induction of pyroptosis and proinflammatory cytokine secretion in the control of growth and elimination of cytosolic bacteria.
Collectively, these results are consistent with a model whereby the type III secretion system apparatus of Pseudomonas aeruginosa activates the caspase-1-dependent inflammasome and caspase-3 (显示 CASP3 抗体)/7 through an ASC (显示 STS 抗体)-dependent mechanism.
The results of this study indicated that beta-Amyloid peptide (显示 APP 抗体)-induced caspase-1 activation, disrupts autophagy in the cortex and in the hippocampus resulting in neurodegeneration and memory loss.
caspase-1 regulates dopaminergic neuronal death in the pathogenesis of Parkinson's disease in mice via caspase-7 (显示 CASP7 抗体)/PARP1 (显示 PARP1 抗体)/AIF (显示 AIFM1 抗体) pathway.
RIP3 (显示 MPRIP 抗体)-mediated activation of caspase-1 rather than necroptosis-dependent inflammation was responsible for aggressive inflammation in influenza A (H7N9) virus-infected mice.
we assessed the role of RIP3 (显示 MPRIP 抗体) in synergy with Caspase-1 in the induction of IL-1beta (显示 IL1B 抗体) production in BMDM after either LPS (显示 TLR4 抗体)/ATP or Chlamydia muridarum stimulation. The possibility of pyroptosis and necroptosis interplays and the role of RIP3 (显示 MPRIP 抗体) in IL-1beta (显示 IL1B 抗体) production during Chlamydia muridarum infection in BMDM was investigated as well.
Studied the role of transient receptor potential melastatin 2 (显示 TRPM3 抗体) (TRPM2 (显示 TRPM2 抗体)) in activating caspase-1 and caspase-1-dependent pyroptosis in mouse BMDMs. Found TRPM2 (显示 TRPM2 抗体) knockout caused higher caspase-1 activation and pyrotopsis.
The results demonstrate the activation of the caspase 1 precursor by caspase 11 (显示 CASP4 抗体) and suggest a new mechanism of protection of Theiler murine encephalomyelitis virus-infected astrocytes from apoptosis.
Nodakenin inhibited the mRNA expression and production of pro-inflammatory cytokines and caspase-1 activation
Adult neural stem cells (ANSCs) expressed NLRP3 (显示 NLRP3 抗体)-containing inflammasome and alpha-syn activated both TLR4 (显示 TLR4 抗体)/NF-kappaB (显示 NFKB1 抗体) and NLRP3 (显示 NLRP3 抗体)/caspase-1 signals in ANSCs.
Src kinase (显示 CSK 抗体) mediates hypoxia-induced caspase-1 activation in the cerebral cortex of newborn piglets
endometrial expression of CASP1 and IL18 (显示 IL18 抗体) associated with pregnancy establishment; alteration of CASP1 and IL18 (显示 IL18 抗体) following premature exposure of uterus to estrogen during early pregnancy may contribute to conceptus loss between Days 15 to 18 of pregnancy
drICE (显示 CASP3 抗体) and dcp-1 (显示 ACE 抗体) function in cell death redundantly. However, dying neurons in a few clusters strictly required drICE (显示 CASP3 抗体) but not dcp-1 (显示 ACE 抗体), but required drICE (显示 CASP3 抗体) and dcp-1 (显示 ACE 抗体) when drICE (显示 CASP3 抗体) activity was reduced via hypomorphic mutation.
Drosophila corazonin-producing interneuron programmed cell death utilizes dronc, strica, dcp-1 (显示 ACE 抗体), and ice
Autophagy suppresses Dcp-1 (显示 ACE 抗体)-mediated apoptotic cell death, whereas Dcp-1 (显示 ACE 抗体) positively regulates autophagy, possibly through feedback regulation.
novel characteristic morphological features of egg chambers lacking both dcp-1 (显示 ACE 抗体) and pita functions in the germline cells; suggested an essential role of dcp-1 (显示 ACE 抗体) and/or pita during mid-oogenesis
A double-mutant analysis between drICE (显示 CASP3 抗体) and death caspase-1 (dcp-1), another effector caspase (显示 CASP3 抗体), reveals that some cells (type I) strictly require drICE (显示 CASP3 抗体) for apoptosis, whereas other cells (type II) require either drICE (显示 CASP3 抗体) or dcp-1 (显示 ACE 抗体).
Data show that the effector caspase Dcp-1 and the inhibitor of apoptosis protein (显示 BIRC2 抗体) Bruce (显示 BIRC6 抗体) function to regulate both autophagy and starvation-induced cell death in Drosophila.
HeT-A mRNA is derepressed in mRNA degradation mutants dcp1 (显示 ACE 抗体), indicating that the enzyme also aid in removing full-length transcripts and/or decay intermediates.
Bombyx mori caspase-1 plays an important role during baculovirus infection.
cBm-IAP1 (显示 BIRC3 抗体) is a vital negative regulator of apoptosis in BM-N cells and functions by preventing the activation and/or activity of Bm-Dronc and Bm-caspase-1.
Activation of Atg5 (显示 ATG5 抗体), AIF (显示 AIFM1 抗体) and caspase (显示 CASP3 抗体) genes in close association with different cell death events revealed the synchronized differential expression of apoptosis-associated genes in response to macroparasitism.
This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce 2 subunits, large and small, that dimerize to form the active enzyme. This gene was identified by its ability to proteolytically cleave and activate the inactive precursor of interleukin-1, a cytokine involved in the processes such as inflammation, septic shock, and wound healing. This gene has been shown to induce cell apoptosis and may function in various developmental stages. Studies of a similar gene in mouse suggest a role in the pathogenesis of Huntington disease. Alternative splicing results in transcript variants encoding distinct isoforms.
CASP1 nirs variant 1
, IL-1 beta-converting enzyme
, caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)
, interleukin 1, beta, convertase
, interleukin 1-B converting enzyme
, IL-1B converting enzyme
, interleukin 1 beta-converting enzyme
, interleukin-1 beta convertase
, interleukin-1 beta-converting enzyme
, Interleukin 1beta converting enzyme
, caspase 1, apoptosis-related cysteine protease (interleukin 1, beta, convertase)
, interleukin-1 beta converting enzyme
, caspase-1/caspase-4 hybrid
, caspase 1
, death caspase-1