XRCC5 抗体 (AA 103-315)
(3 references)-
- 抗原 See all XRCC5 抗体
- XRCC5 (X-Ray Repair Complementing Defective Repair in Chinese Hamster Cells 5 (Double-Strand-Break Rejoining) (XRCC5))
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抗原表位
- AA 103-315
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适用
- 人
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- This XRCC5 antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunofluorescence (IF)
- 产品特性
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1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States. - 纯化方法
- The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
- 免疫原
- Human Ku80 aa. 103-315
- 克隆位点
- 7-Ku80
- 亚型
- IgG1
- Top Product
- Discover our top product XRCC5 Primary Antibody
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anti-X-Ray Repair Complementing Defective Repair in Chinese Hamster Cells 5 (Double-Strand-Break Rejoining) (XRCC5) (AA 1-732) antibody
XRCC5 适用: 人 WB, ELISA, IF, IHC (p) 宿主: 小鼠 Monoclonal 3D8 unconjugated
anti-X-Ray Repair Complementing Defective Repair in Chinese Hamster Cells 5 (Double-Strand-Break Rejoining) (XRCC5) (AA 543-732) antibodyXRCC5 适用: 人 WB, IHC, IF, IP 宿主: 兔 Polyclonal unconjugated
anti-X-Ray Repair Complementing Defective Repair in Chinese Hamster Cells 5 (Double-Strand-Break Rejoining) (XRCC5) antibodyXRCC5 适用: 人, 小鼠, 大鼠 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-X-Ray Repair Complementing Defective Repair in Chinese Hamster Cells 5 (Double-Strand-Break Rejoining) (XRCC5) antibodyXRCC5 适用: 人, 小鼠 WB, IHC, ELISA, FACS, ICC 宿主: 小鼠 Monoclonal 5C5 unconjugated
anti-X-Ray Repair Complementing Defective Repair in Chinese Hamster Cells 5 (Double-Strand-Break Rejoining) (XRCC5) (AA 648-662), (C-Term) antibodyXRCC5 适用: 人 WB, IHC (p), ICC 宿主: 兔 Polyclonal unconjugated
anti-X-Ray Repair Complementing Defective Repair in Chinese Hamster Cells 5 (Double-Strand-Break Rejoining) (XRCC5) (AA 251-455) antibodyXRCC5 适用: 人 WB, IHC, ELISA, IP 宿主: 兔 Polyclonal unconjugated
anti-X-Ray Repair Complementing Defective Repair in Chinese Hamster Cells 5 (Double-Strand-Break Rejoining) (XRCC5) antibodyXRCC5 适用: 人 WB, IHC, ELISA, IF 宿主: 兔 Monoclonal 5G3 unconjugated Recombinant Antibody
anti-X-Ray Repair Complementing Defective Repair in Chinese Hamster Cells 5 (Double-Strand-Break Rejoining) (XRCC5) (AA 540-732) antibodyXRCC5 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-X-Ray Repair Complementing Defective Repair in Chinese Hamster Cells 5 (Double-Strand-Break Rejoining) (XRCC5) antibodyXRCC5 适用: 人 WB, IHC, IF, IP 宿主: 兔 Monoclonal unconjugated
anti-X-Ray Repair Complementing Defective Repair in Chinese Hamster Cells 5 (Double-Strand-Break Rejoining) (XRCC5) (C-Term) antibodyXRCC5 适用: 人, 小鼠, 大鼠, 犬, 马, 兔, Cow, 豚鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
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- 说明
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Related Products: ABIN968533, ABIN967389
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 250 μg/mL
- 缓冲液
- Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store undiluted at -20° C.
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: "Ku autoantigen affects the susceptibility to anticancer drugs." in: Cancer research, Vol. 59, Issue 16, pp. 4012-7, (1999) (PubMed).
: "Hypermethylation of metallothionein-I promoter and suppression of its induction in cell lines overexpressing the large subunit of Ku protein." in: The Journal of biological chemistry, Vol. 274, Issue 40, pp. 28584-9, (1999) (PubMed).
: "The DNA-dependent protein kinase." in: Genes & development, Vol. 13, Issue 8, pp. 916-34, (1999) (PubMed).
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: "Ku autoantigen affects the susceptibility to anticancer drugs." in: Cancer research, Vol. 59, Issue 16, pp. 4012-7, (1999) (PubMed).
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- 抗原
- XRCC5 (X-Ray Repair Complementing Defective Repair in Chinese Hamster Cells 5 (Double-Strand-Break Rejoining) (XRCC5))
- 别名
- Ku80 (XRCC5 产品)
- 别名
- AI314015 antibody, Ku80 antibody, Ku86 antibody, Kup80 antibody, KARP-1 antibody, KARP1 antibody, KU80 antibody, KUB2 antibody, NFIV antibody, xrcc5-a antibody, XRCC5 antibody, X-ray repair cross complementing 5 antibody, X-ray repair complementing defective repair in Chinese hamster cells 5 antibody, X-ray repair complementing defective repair in Chinese hamster cells 5 L homeolog antibody, XRCC5 antibody, Xrcc5 antibody, xrcc5.L antibody
- 背景
- DNA-dependent protein kinase (DNA-PK) is a trimeric enzyme that contains a catalytic subunit of 350 kDa (DNA-PKcs) and a heterodimeric regulatory subunit of 70 kDa (Ku70) and 86 kDa (Ku80). DNA-PKcs is inactive alone and depends on the regulatory subunit for subcellular localization and kinase activity. The DNA-PKcs/Ku70/Ku80 complex is involved in V(D)J recombination and DNA double-stranded break repair. Ku70 and Ku80 are abundant nuclear DNA-binding proteins. Besides functioning in a complex with DNA-PKcs, Ku proteins may act in multiple cellular processes including transcriptional regulation, ATPase and helicase activity, alteration in chromatin structure, cell cycle regulation, and maintenance of telomere length. In rat fibroblasts, Ku80 overexpression leads to hypermethylation and silencing of metallothionein gene expression. Ku70-/- and Ku80-/- cells are less resistant to anticancer drug-induced apoptosis, suggesting a role for Ku proteins in the prevention of apoptotic signaling. Thus, Ku70 and Ku80 may have multiple roles during DNA transcription, repair, and maintenance depending on the protein interactions that are involved.
- 分子量
- 80 kDa
- 途径
- DNA Damage Repair
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