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XRCC5 抗体 (AA 251-455)

Name: XRCC5 抗体 (AA 251-455)
Brand: antibodies-online
SKU: ABIN7175897
Availability: OutOfStock

XRCC5 适用: 人 WB, IHC, ELISA, IP 宿主: 兔 Polyclonal unconjugated

Western Blot Positive WB detected in: LO2 whole cell lysate All lanes: XRCC5 antibody at 3. (XRCC5 抗体 (AA 251-455))

Immunohistochemistry of paraffin-embedded human colon cancer using ABIN7175897 at dilution of 1:100 (XRCC5 抗体 (AA 251-455))

IHC

Immunohistochemistry of paraffin-embedded human melanoma using ABIN7175897 at dilution of 1:100 (XRCC5 抗体 (AA 251-455))

IHC

Immunoprecipitating XRCC5 in HepG2 whole cell lysate Lane 1: Rabbit control IgG (1 μg) instead of ABIN7175897 in HepG2 whole cell lysate. (XRCC5 抗体 (AA 251-455))

4 images

产品编号 ABIN7175897

发货至: 中国

Datasheet as PDF

抗原 See all XRCC5 抗体

XRCC5 (X-Ray Repair Complementing Defective Repair in Chinese Hamster Cells 5 (Double-Strand-Break Rejoining) (XRCC5))
抗原表位
15

14

8

7

6

6

5

4

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
AA 251-455
适用
94

14

11

5

2

2

1

1

1

1

1
人
宿主
77

14

2

1
兔
Compatible Secondaries
克隆类型
69

23
多克隆
标记
64

4

4

3

2

2

2

2

2

2

1

1

1

1

1

1

1
This XRCC5 antibody is un-conjugated
应用范围
80

40

38

30

20

12

11

10

4

3

2

2

2

1

1
Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunoprecipitation (IP)

交叉反应

人

纯化方法

>95%, Protein G purified

免疫原

Recombinant Human X-ray repair cross-complementing protein 5 protein (251-455AA)

亚型

IgG

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anti-X-Ray Repair Complementing Defective Repair in Chinese Hamster Cells 5 (Double-Strand-Break Rejoining) (XRCC5) (AA 543-732) antibody
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anti-X-Ray Repair Complementing Defective Repair in Chinese Hamster Cells 5 (Double-Strand-Break Rejoining) (XRCC5) antibody
XRCC5 适用: 人, 小鼠, 大鼠 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated

anti-X-Ray Repair Complementing Defective Repair in Chinese Hamster Cells 5 (Double-Strand-Break Rejoining) (XRCC5) antibody
XRCC5 适用: 人, 小鼠 WB, IHC, ELISA, FACS, ICC 宿主: 小鼠 Monoclonal 5C5 unconjugated

anti-X-Ray Repair Complementing Defective Repair in Chinese Hamster Cells 5 (Double-Strand-Break Rejoining) (XRCC5) (AA 648-662), (C-Term) antibody
XRCC5 适用: 人 WB, IHC (p), ICC 宿主: 兔 Polyclonal unconjugated

anti-X-Ray Repair Complementing Defective Repair in Chinese Hamster Cells 5 (Double-Strand-Break Rejoining) (XRCC5) antibody
XRCC5 适用: 人 WB, IHC, ELISA, IF 宿主: 兔 Monoclonal 5G3 unconjugated Recombinant Antibody

anti-X-Ray Repair Complementing Defective Repair in Chinese Hamster Cells 5 (Double-Strand-Break Rejoining) (XRCC5) (AA 540-732) antibody
XRCC5 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated

anti-X-Ray Repair Complementing Defective Repair in Chinese Hamster Cells 5 (Double-Strand-Break Rejoining) (XRCC5) antibody
XRCC5 适用: 人 WB, IHC, IF, IP 宿主: 兔 Monoclonal unconjugated

anti-X-Ray Repair Complementing Defective Repair in Chinese Hamster Cells 5 (Double-Strand-Break Rejoining) (XRCC5) (C-Term) antibody
XRCC5 适用: 人, 小鼠, 大鼠, 犬, 马, 兔, Cow, 豚鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated

anti-X-Ray Repair Complementing Defective Repair in Chinese Hamster Cells 5 (Double-Strand-Break Rejoining) (XRCC5) (AA 424-450) antibody
XRCC5 适用: 人 WB, ELISA, IF, FACS 宿主: 兔 Polyclonal unconjugated

应用备注

Recommended dilution: WB:1:500-1:5000, IHC:1:20-1:200, IP:1:200-1:2000,

限制

仅限研究用
状态

Liquid

缓冲液

Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

储存液

ProClin

注意事项

This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

-20 °C,-80 °C

储存方法

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
抗原

XRCC5 (X-Ray Repair Complementing Defective Repair in Chinese Hamster Cells 5 (Double-Strand-Break Rejoining) (XRCC5))

别名

XRCC5 (XRCC5 产品)

别名

AI314015 antibody, Ku80 antibody, Ku86 antibody, Kup80 antibody, KARP-1 antibody, KARP1 antibody, KU80 antibody, KUB2 antibody, NFIV antibody, xrcc5-a antibody, XRCC5 antibody, X-ray repair cross complementing 5 antibody, X-ray repair complementing defective repair in Chinese hamster cells 5 antibody, X-ray repair complementing defective repair in Chinese hamster cells 5 L homeolog antibody, XRCC5 antibody, Xrcc5 antibody, xrcc5.L antibody

背景

Background: Single-stranded DNA-dependent ATP-dependent helicase. Has a role in chromosome translocation. The DNA helicase II complex binds preferentially to fork-like ends of double-stranded DNA in a cell cycle-dependent manner. It works in the 3\\\'-5\\\' direction. Binding to DNA may be mediated by XRCC6. Involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination. The XRCC5/6 dimer acts as regulatory subunit of the DNA-dependent protein kinase complex DNA-PK by increasing the affinity of the catalytic subunit PRKDC to DNA by 100-fold. The XRCC5/6 dimer is probably involved in stabilizing broken DNA ends and bringing them together (PubMed:12145306, PubMed:20383123, PubMed:7957065, PubMed:8621488). The assembly of the DNA-PK complex to DNA ends is required for the NHEJ ligation step. In association with NAA15, the XRCC5/6 dimer binds to the osteocalcin promoter and activates osteocalcin expression (PubMed:20383123). The XRCC5/6 dimer probably also acts as a 5\\\'-deoxyribose-5-phosphate lyase (5\\\'-dRP lyase), by catalyzing the beta-elimination of the 5\\\' deoxyribose-5-phosphate at an abasic site near double-strand breaks. XRCC5 probably acts as the catalytic subunit of 5\\\'-dRP activity, and allows to \\\'clean\\\' the termini of abasic sites, a class of nucleotide damage commonly associated with strand breaks, before such broken ends can be joined. The XRCC5/6 dimer together with APEX1 acts as a negative regulator of transcription (PubMed:8621488).
Aliases: 86 kDa subunit of Ku antigen antibody, ATP dependent DNA helicase 2 subunit 2 antibody, ATP dependent DNA helicase II 80 kDa subunit antibody, ATP dependent DNA helicase II 86 Kd subunit antibody, ATP dependent DNA helicase II antibody, ATP-dependent DNA helicase 2 subunit 2 antibody, ATP-dependent DNA helicase II 80 kDa subunit antibody, CTC box binding factor 85 kDa antibody, CTC box-binding factor 85 kDa subunit antibody, CTC85 antibody, CTCBF antibody, DNA repair protein XRCC5 antibody, KARP 1 antibody, KARP1 antibody, Ku 80 antibody, Ku autoantigen 80 kDa antibody, Ku80 antibody, Ku86 antibody, Ku86 autoantigen related protein 1 antibody, KUB 2 antibody, KUB2 antibody, Lupus Ku autoantigen protein p86 antibody, NFIV antibody, Nuclear factor IV antibody, Thyroid lupus autoantigen antibody, Thyroid-lupus autoantigen antibody, TLAA antibody, X ray repair complementing defective repair in Chinese hamster cells 5 (double strand break rejoining) antibody, X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) antibody, X-ray repair cross-complementing protein 5 antibody, Xray repair complementing defective repair in Chinese hamster cells 5 antibody, XRCC 5 antibody, XRCC5 antibody, XRCC5_HUMAN antibody

UniProt

P13010

途径

DNA Damage Repair