BRAF is one of the main effectors recruited by GTP-bound Ras to activate the MEK-MAP kinase pathway. B-Raf contains three consensus Akt phosphorylation sites. B-Raf is a key regulatory molecule of the mitogen-activated protein kinase kinase (MEK), it has a long amino-terminal region,the region is essential for homo-dimerization of B-Raf and hetero-dimerization of B-Raf and c-Raf at the plasma membrane, followed by phosphorylation of Thr118 in the amino-terminal B-Raf-specific region. Notably, in calcium ionophore-stimulated HeLa cells, B-Raf could propagate signals to MEK under the basal level of GTP-Ras. Synonyms: Monoclonal BRAF antibody, Anti-BRAF antibody, V-raf murine sarcoma viral oncogene homolog B1 antibody, BRAF1 antibody, RAFB1 antibody, B-RAF1 antibody, B RAF1 antibody.