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XRCC5 抗体 (AA 300-500)

Name: XRCC5 抗体 (AA 300-500)
Brand: antibodies-online
SKU: ABIN7127058
Availability: OutOfStock

XRCC5 适用: 人 WB, IHC (f) 宿主: 小鼠 Monoclonal unconjugated

产品编号 ABIN7127058

发货至: 中国

Datasheet as PDF

抗原 See all XRCC5 抗体

XRCC5 (X-Ray Repair Complementing Defective Repair in Chinese Hamster Cells 5 (Double-Strand-Break Rejoining) (XRCC5))
抗原表位
15

14

8

7

6

6

6

4

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1
AA 300-500
适用
91

14

11

5

2

2

1

1

1

1

1
人
宿主
78

11

2
小鼠
Compatible Secondaries
克隆类型
69

20
单克隆
标记
61

4

4

3

2

2

2

2

2

2

1

1

1

1

1

1

1
This XRCC5 antibody is un-conjugated
应用范围
78

40

38

29

20

12

11

9

4

3

2

2

2

1
Western Blotting (WB), Immunohistochemistry (Formalin-fixed Sections) (IHC (f))

特异性

The Ku protein is localized in the nucleus and is composed of subunits referred to as Ku-70 (or p70) and Ku-86 or (p86) which is also known by the synonym Ku-80 or (p80). Ku was first described as an autoantigen to which antibodies were produced in a patient with scleroderma-polymyositis overlap syndrome, and was later found in the sera of patients with other rheumatic diseases. Ku has several functions, including cell signaling, DNA replication and transcriptional activation. Ku is involved in Pol II-directed transcription by virtue of its DNA binding activity, serving as the regulatory component of the DNA-associated protein kinase that phosphorylates Pol II and transcription factor Sp. Ku proteins also activate transcription from the U1 small nuclear RNA and the human transferrin receptor gene promoters.

交叉反应（详细）

Human.

纯化方法

1.0mg/ml of Ab purified from Bioreactor by Protein A/G.

免疫原

Recombinant fragment (around aa300-500) of human XRCC5 (exact sequence is proprietary)

亚型

IgG1

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anti-X-Ray Repair Complementing Defective Repair in Chinese Hamster Cells 5 (Double-Strand-Break Rejoining) (XRCC5) (AA 648-662), (C-Term) antibody
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anti-X-Ray Repair Complementing Defective Repair in Chinese Hamster Cells 5 (Double-Strand-Break Rejoining) (XRCC5) antibody
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anti-X-Ray Repair Complementing Defective Repair in Chinese Hamster Cells 5 (Double-Strand-Break Rejoining) (XRCC5) (AA 540-732) antibody
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anti-X-Ray Repair Complementing Defective Repair in Chinese Hamster Cells 5 (Double-Strand-Break Rejoining) (XRCC5) antibody
XRCC5 适用: 人 WB, IHC, IF, IP 宿主: 兔 Monoclonal unconjugated

anti-X-Ray Repair Complementing Defective Repair in Chinese Hamster Cells 5 (Double-Strand-Break Rejoining) (XRCC5) (C-Term) antibody
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应用备注

Known_Application: Western Blot (1-2 μg/mL),Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT),(Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95 °C followed by cooling at RT for 20 minutes),Optimal dilution for a specific application should be determined.
Positive_Control: HeLa, MOLT-4, MCF-7 or HT29 cells. Human thyroid or lymph node.

限制

仅限研究用
浓度

1.0 mg/mL

缓冲液

Prepared in 10 mM PBS, WITHOUT BSA and Azide.

储存液

Azide free

储存条件

-20 °C,-80 °C

储存方法

Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.

有效期

24 months
抗原

XRCC5 (X-Ray Repair Complementing Defective Repair in Chinese Hamster Cells 5 (Double-Strand-Break Rejoining) (XRCC5))

别名

XRCC5 (XRCC5 产品)

别名

AI314015 antibody, Ku80 antibody, Ku86 antibody, Kup80 antibody, KARP-1 antibody, KARP1 antibody, KU80 antibody, KUB2 antibody, NFIV antibody, xrcc5-a antibody, XRCC5 antibody, X-ray repair cross complementing 5 antibody, X-ray repair complementing defective repair in Chinese hamster cells 5 antibody, X-ray repair complementing defective repair in Chinese hamster cells 5 L homeolog antibody, XRCC5 antibody, Xrcc5 antibody, xrcc5.L antibody

背景

ATP-dependent DNA helicase II 80 kDa subunit, CTC box-binding factor 85 kDa subunit (CTC85), CTCBF, DNA repair protein XRCC5, KARP1, Ku autoantigen 80 kDa, Ku80, Ku86, KUB2, Lupus Ku autoantigen protein p86, Nuclear factor IV (NFIV), Thyroid-lupus autoantigen, TLAA, X-ray repair cross-complementing protein 5 (XRCC5),XRCC5 (Ku86 / Ku80) (Thyroid-Lupus Autoantigen)
Cellular localisation: Nucleus. Nucleoplasm.

分子量

80-86kDa

基因ID

7520, 388739

UniProt

P13010

途径

DNA Damage Repair