NPC1 抗体 (C-Term)
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- 抗原 See all NPC1 抗体
- NPC1 (Niemann-Pick Disease, Type C1 (NPC1))
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抗原表位
- C-Term
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适用
- 人, 小鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This NPC1 antibody is un-conjugated
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应用范围
- ELISA, Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- 纯化方法
- NPC1 Antibody is affinity chromatography purified via peptide column.
- 免疫原
- NPC1 antibody was raised against a 16 amino acid synthetic peptide from near the carboxy terminus of human NPC1. The immunogen is located within the last 50 amino acids of NPC1.
- 亚型
- IgG
- Top Product
- Discover our top product NPC1 Primary Antibody
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anti-Niemann-Pick Disease, Type C1 (NPC1) (AA 34-174) antibody
NPC1 适用: 人 ELISA, WB, IHC, FACS 宿主: 小鼠 Monoclonal 8D10G3 unconjugated
anti-Niemann-Pick Disease, Type C1 (NPC1) (AA 34-174) antibodyNPC1 适用: 人 ELISA, WB, IHC 宿主: 小鼠 Monoclonal 8D10B6 unconjugated
anti-Niemann-Pick Disease, Type C1 (NPC1) (AA 34-174) antibodyNPC1 适用: 人 ELISA, WB, IHC, FACS 宿主: 小鼠 Monoclonal unconjugated
anti-Niemann-Pick Disease, Type C1 (NPC1) (AA 591-620) antibodyNPC1 适用: 人 ELISA, WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Niemann-Pick Disease, Type C1 (NPC1) (AA 23-269) antibodyNPC1 适用: 人 ELISA, WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Niemann-Pick Disease, Type C1 (NPC1) (AA 151-250) antibodyNPC1 适用: 人 ELISA, WB 宿主: 小鼠 Monoclonal 4H2 unconjugated
anti-Niemann-Pick Disease, Type C1 (NPC1) antibodyNPC1 适用: 人 WB, IHC, IF, IHC (p), IP 宿主: 小鼠 Monoclonal unconjugated
anti-Niemann-Pick Disease, Type C1 (NPC1) (AA 591-620) antibodyNPC1 适用: 人 WB, IF, IHC (p) 宿主: 兔 Polyclonal RB33297 unconjugated
anti-Niemann-Pick Disease, Type C1 (NPC1) (Internal Region) antibodyVerified NPC1 适用: 人 ELISA, WB 宿主: 山羊 Polyclonal unconjugated
anti-Niemann-Pick Disease, Type C1 (NPC1) (C-Term) antibodyNPC1 适用: 人, 小鼠, Hamster WB, IHC, IF, IP 宿主: 兔 Polyclonal unconjugated
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- 应用备注
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NPC1 antibody can be used for detection of NPC1 by Western blot at 1 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.
Antibody validated: Western Blot in human samples, Immunohistochemistry in mouse samples and Immunofluorescence in mouse samples. All other applications and species not yet tested. - 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 mg/mL
- 缓冲液
- NPC1 Antibody is supplied in PBS containing 0.02 % sodium azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C,4 °C
- 储存方法
- NPC1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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- 抗原
- NPC1 (Niemann-Pick Disease, Type C1 (NPC1))
- 别名
- NPC1 (NPC1 产品)
- 别名
- NPC antibody, 9130221N23Rik antibody, Gm243 antibody, Cdig2 antibody, im:7149020 antibody, wu:fb53a12 antibody, wu:fc29a12 antibody, A430089E03Rik antibody, C85354 antibody, D18Ertd139e antibody, D18Ertd723e antibody, lcsd antibody, nmf164 antibody, spm antibody, NPC intracellular cholesterol transporter 1 antibody, NPC1 like intracellular cholesterol transporter 1 antibody, Niemann-Pick disease, type C1 antibody, Niemann-Pick C1 protein antibody, NPC1 antibody, Npc1l1 antibody, Npc1 antibody, npc1 antibody, LOC579887 antibody
- 背景
- NPC1 Antibody: Mutations in the Niemann-Pick disease type C1 (NPC1) gene result in a fatal progressive neurodegenerative disorder characterized by an abnormal sequestration of lipids including cholesterol and glycosphingolipids. The NPC1 protein is a large protein that resides in the limiting membrane of endosomes and lysosomes and mediates intracellular cholesterol trafficking via binding of cholesterol to its N-terminal domain. NPC1 transports low-density lipoproteins to late endosomal/lysosomal compartments where they are hydrolized and released as free cholesterol. NPC1, in addition to FTO, MC4R, and PTER has recently been shown to be a new risk loci for early-onset and morbid adult obesity in European populations. This anti-NPC1 antibody will not cross-react to NPC2, another gene whose defects also result in Niemann-Pick type C disease.
- 分子量
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Predicted: 140 kDa
Observed: 150 kDa - 基因ID
- 4864
- NCBI登录号
- NP_000262
- UniProt
- O15118
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