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NPC1 抗体 (AA 34-174)

NPC1 适用: 人 ELISA, WB, IHC, FACS 宿主: 小鼠 Monoclonal unconjugated
产品编号 ABIN1845969
发货至: 中国
  • 抗原 See all NPC1 抗体
    NPC1 (Niemann-Pick Disease, Type C1 (NPC1))
    抗原表位
    • 8
    • 6
    • 6
    • 5
    • 5
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    AA 34-174
    适用
    • 45
    • 19
    • 14
    • 2
    宿主
    • 41
    • 4
    • 2
    小鼠
    克隆类型
    • 35
    • 12
    单克隆
    标记
    • 20
    • 5
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    This NPC1 antibody is un-conjugated
    应用范围
    • 29
    • 27
    • 19
    • 14
    • 6
    • 6
    • 4
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    ELISA, Western Blotting (WB), Immunohistochemistry (IHC), Flow Cytometry (FACS)
    纯化方法
    Purified
    免疫原
    Purified recombinant fragment of human NPC1 (AA: 34-174) expressed in E. coli.
    亚型
    IgG1
    Top Product
    Discover our top product NPC1 Primary Antibody
  • 限制
    仅限研究用
  • 缓冲液
    Purified antibody in PBS with 0.05% sodium azide and 0.5% protein stabilizer.
    储存液
    Sodium azide
    注意事项
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    -20 °C
    储存方法
    Aliquot and store at -20 °C.
  • 抗原
    NPC1 (Niemann-Pick Disease, Type C1 (NPC1))
    别名
    NPC1 (NPC1 产品)
    背景
    This gene encodes a large protein that resides in the limiting membrane of endosomes and lysosomes and mediates intracellular cholesterol trafficking via binding of cholesterol to its N-terminal domain.It is predicted to have a cytoplasmic C-terminus, 13 transmembrane domains, and 3 large loops in the lumen of the endosome - the last loop being at the N-terminus.This protein transports low-density lipoproteins to late endosomal/lysosomal compartments where they are hydrolized and released as free cholesterol.Defects in this gene cause Niemann-Pick type C disease, a rare autosomal recessive neurodegenerative disorder characterized by over accumulation of cholesterol and glycosphingolipids in late endosomal/lysosomal compartments.
    分子量
    142.2 kDa
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