NPC1 抗体 (AA 34-174)
(2 references)-
- 抗原 See all NPC1 抗体
- NPC1 (Niemann-Pick Disease, Type C1 (NPC1))
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抗原表位
- AA 34-174
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适用
- 人
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- This NPC1 antibody is un-conjugated
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应用范围
- ELISA, Western Blotting (WB), Immunohistochemistry (IHC), Flow Cytometry (FACS)
- 纯化方法
- Purified
- 免疫原
- Purified recombinant fragment of human NPC1 (AA: 34-174) expressed in E. Coli.
- 克隆位点
- 8D10G3
- 亚型
- IgG1
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anti-Niemann-Pick Disease, Type C1 (NPC1) (AA 34-174) antibody
NPC1 适用: 人 ELISA, WB, IHC 宿主: 小鼠 Monoclonal 8D10B6 unconjugated
anti-Niemann-Pick Disease, Type C1 (NPC1) (AA 34-174) antibodyNPC1 适用: 人 ELISA, WB, IHC, FACS 宿主: 小鼠 Monoclonal unconjugated
anti-Niemann-Pick Disease, Type C1 (NPC1) (AA 591-620) antibodyNPC1 适用: 人 ELISA, WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Niemann-Pick Disease, Type C1 (NPC1) (AA 23-269) antibodyNPC1 适用: 人 ELISA, WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Niemann-Pick Disease, Type C1 (NPC1) (AA 151-250) antibodyNPC1 适用: 人 ELISA, WB 宿主: 小鼠 Monoclonal 4H2 unconjugated
anti-Niemann-Pick Disease, Type C1 (NPC1) antibodyNPC1 适用: 人 WB, IHC, IF, IHC (p), IP 宿主: 小鼠 Monoclonal unconjugated
anti-Niemann-Pick Disease, Type C1 (NPC1) (AA 1230-1278) antibodyNPC1 适用: 人, 小鼠, Hamster WB, IHC, IF, IP, IEM 宿主: 兔 Polyclonal unconjugated
anti-Niemann-Pick Disease, Type C1 (NPC1) (AA 591-620) antibodyNPC1 适用: 人 WB, IF, IHC (p) 宿主: 兔 Polyclonal RB33297 unconjugated
anti-Niemann-Pick Disease, Type C1 (NPC1) (Internal Region) antibodyVerified NPC1 适用: 人 ELISA, WB 宿主: 山羊 Polyclonal unconjugated
anti-Niemann-Pick Disease, Type C1 (NPC1) (C-Term) antibodyNPC1 适用: 人 WB, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
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- 应用备注
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Recommended Dilution:
ELISA: 1/10000
WB: 1/500 - 1/2000
IHC: 1/200 - 1/1000
FCM: 1/200 - 1/400 - 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
- PBS with 0.05 % sodium azide and 0.5 % protein stabilizer
- 储存液
- Sodium azide
- 注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C/-20 °C
- 储存方法
- Store at 4 °C or at -20 °C for long term.
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: "Deficiency of Niemann-Pick C1 protein protects against diet-induced gallstone formation in mice." in: Liver international : official journal of the International Association for the Study of the Liver, Vol. 30, Issue 6, pp. 887-97, (2010) (PubMed).
: "Defects of synaptic vesicle turnover at excitatory and inhibitory synapses in Niemann-Pick C1-deficient neurons." in: Neuroscience, Vol. 167, Issue 3, pp. 608-20, (2010) (PubMed).
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: "Deficiency of Niemann-Pick C1 protein protects against diet-induced gallstone formation in mice." in: Liver international : official journal of the International Association for the Study of the Liver, Vol. 30, Issue 6, pp. 887-97, (2010) (PubMed).
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- 抗原
- NPC1 (Niemann-Pick Disease, Type C1 (NPC1))
- 别名
- NPC1 (NPC1 产品)
- 别名
- NPC antibody, 9130221N23Rik antibody, Gm243 antibody, Cdig2 antibody, im:7149020 antibody, wu:fb53a12 antibody, wu:fc29a12 antibody, A430089E03Rik antibody, C85354 antibody, D18Ertd139e antibody, D18Ertd723e antibody, lcsd antibody, nmf164 antibody, spm antibody, NPC intracellular cholesterol transporter 1 antibody, NPC1 like intracellular cholesterol transporter 1 antibody, Niemann-Pick disease, type C1 antibody, Niemann-Pick C1 protein antibody, NPC1 antibody, Npc1l1 antibody, Npc1 antibody, npc1 antibody, LOC579887 antibody
- 背景
- This gene encodes a large protein that resides in the limiting membrane of endosomes and lysosomes and mediates intracellular cholesterol trafficking via binding of cholesterol to its N-terminal domain. It is predicted to have a cytoplasmic C-terminus, 13 transmembrane domains, and 3 large loops in the lumen of the endosome - the last loop being at the N-terminus. This protein transports low-density lipoproteins to late endosomal/lysosomal compartments where they are hydrolized and released as free cholesterol. Defects in this gene cause Niemann-Pick type C disease, a rare autosomal recessive neurodegenerative disorder characterized by over accumulation of cholesterol and glycosphingolipids in late endosomal/lysosomal compartments.
- 分子量
- 142.2 kDa
- 基因ID
- 4864
- HGNC
- 4864
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