FZR1 抗体
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- 抗原 See all FZR1 抗体
- FZR1 (Fizzy/cell Division Cycle 20 Related 1 (FZR1))
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This FZR1 antibody is un-conjugated
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应用范围
- Western Blotting (WB)
- 纯化方法
- Affinity purified
- 免疫原
- FZR1 antibody was raised using a synthetic peptide corresponding to a region with amino acids SSPVSSPSKHGDRFIPSRAGANWSVNFHRINENEKSPSQNRKAKDATSDN
- Top Product
- Discover our top product FZR1 Primary Antibody
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- 应用备注
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WB: 1 µg/mL
Optimal conditions should be determined by the investigator. - 说明
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FZR1 Blocking Peptide, catalog no. 33R-8839, is also available for use as a blocking control in assays to test for specificity of this FZR1 antibody
- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Lyophilized powder. Add distilled water for a 1 mg/mL concentration of FZR1 antibody in PBS
- 浓度
- Lot specific
- 缓冲液
- PBS
- 注意事项
- Avoid repeated freeze/thaw cycles.
- 储存条件
- 4 °C/-20 °C
- 储存方法
- Store at 2-8 °C for short periods. For longer periods of storage, store at -20 °C.
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- 抗原
- FZR1 (Fizzy/cell Division Cycle 20 Related 1 (FZR1))
- 别名
- FZR1 (FZR1 产品)
- 别名
- CDH1-C antibody, FYR antibody, FZR antibody, CDH1 antibody, fzr1 antibody, CDC20C antibody, FZR2 antibody, HCDH antibody, HCDH1 antibody, AW108046 antibody, Cdh1 antibody, Fyr antibody, zgc:55450 antibody, fizzy and cell division cycle 20 related 1 antibody, fizzy/cell division cycle 20 related 1 antibody, fizzy-related protein homolog antibody, fizzy/cell division cycle 20 related 1 (Drosophila) antibody, fizzy/cell division cycle 20 related 1a antibody, Fzr1 antibody, CDH1-C antibody, FZR1 antibody, LOC100027495 antibody, LOC100179951 antibody, fzr1a antibody
- 背景
- FZR1 is a key regulator of ligase activity of the anaphase promoting complex/cyclosome (APC/C), which confers substrate specificity upon the complex. FZR1 associates with the APC/C in late mitosis, in replacement of CDC20, and activates the APC/C during anaphase and telophase. The APC/C remains active in degrading substrates to ensure that positive regulators of the cell cycle do not accumulate prematurely. At the G1/S transition FZR1 is phosphorylated, leading to its dissociation from the APC/C. Following DNA damage, it is required for the G2 DNA damage checkpoint: its dephosphorylation and reassociation with the APC/C leads to the ubiquitination of PLK1, preventing entry into mitosis.
- 分子量
- 55 kDa (MW of target protein)
- 途径
- DNA Replication, Synthesis of DNA
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