-
- 抗原 See all FZR1 抗体
- FZR1 (Fizzy/cell Division Cycle 20 Related 1 (FZR1))
-
抗原表位
- AA 224-493
-
适用
- 人
-
宿主
- 兔
-
克隆类型
- 多克隆
-
标记
- This FZR1 antibody is un-conjugated
-
应用范围
- Western Blotting (WB), Immunofluorescence (IF)
- 序列
- DLSVEGDSVT SVGWSERGNL VAVGTHKGFV QIWDAAAGKK LSMLEGHTAR VGALAWNAEQ LSSGSRDRMI LQRDIRTPPL QSERRLQGHR QEVCGLKWST DHQLLASGGN DNKLLVWNHS SLSPVQQYTE HLAAVKAIAW SPHQHGLLAS GGGTADRCIR FWNTLTGQPL QCIDTGSQVC NLAWSKHANE LVSTHGYSQN QILVWKYPSL TQVAKLTGHS YRVLYLAMSP DGEAIVTGAG DETLRFWNVF SKTRSTKESV SVLNLFTRIR
- 交叉反应
- 人, 小鼠
- 产品特性
- Polyclonal Antibodies
- 纯化方法
- Affinity purification
- 免疫原
- Recombinant fusion protein containing a sequence corresponding to amino acids 224-493 of human FZR1 (NP_057347.2).
- 亚型
- IgG
- Top Product
- Discover our top product FZR1 Primary Antibody
-
anti-Fizzy/cell Division Cycle 20 Related 1 (FZR1) (AA 1-493) antibody
FZR1 适用: 人 WB, ELISA, IHC (p), PLA 宿主: 小鼠 Monoclonal 4C4 unconjugated
anti-Fizzy/cell Division Cycle 20 Related 1 (FZR1) (N-Term) antibodyFZR1 适用: 人, 小鼠, 大鼠, Cow, 犬, 豚鼠, 马, 斑马鱼 WB 宿主: 兔 Polyclonal unconjugated
anti-Fizzy/cell Division Cycle 20 Related 1 (FZR1) (AA 141-240) antibodyFZR1 适用: 人, 小鼠 WB, ELISA, IF (cc), IF (p), IHC (p), ICC, IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Fizzy/cell Division Cycle 20 Related 1 (FZR1) (AA 1-101) antibodyFZR1 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 3E12 unconjugated
anti-Fizzy/cell Division Cycle 20 Related 1 (FZR1) (AA 1-494) antibodyFZR1 适用: 人 WB, ELISA, IHC, IHC (p) 宿主: 小鼠 Monoclonal 4C4 unconjugated
anti-Fizzy/cell Division Cycle 20 Related 1 (FZR1) (AA 1-493) antibodyFZR1 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Fizzy/cell Division Cycle 20 Related 1 (FZR1) (AA 1-496) antibodyFZR1 适用: 人 WB 宿主: 小鼠 Monoclonal 1621CT637-76-67 unconjugated
anti-Fizzy/cell Division Cycle 20 Related 1 (FZR1) (N-Term) antibodyFZR1 适用: 人, 小鼠, 大鼠, Bat, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-Fizzy/cell Division Cycle 20 Related 1 (FZR1) antibodyFZR1 适用: 人, 小鼠 IF 宿主: 兔 Polyclonal unconjugated
anti-Fizzy/cell Division Cycle 20 Related 1 (FZR1) (AA 35-84) antibodyFZR1 适用: 人, 小鼠, 大鼠, Cow, 犬, 豚鼠, 马, 斑马鱼, Pig, Bat, 猴, 小鸡, Hamster, 非洲爪蟾 WB 宿主: 兔 Polyclonal unconjugated
-
- 应用备注
- WB,1:500 - 1:2000,IF,1:50 - 1:200
- 限制
- 仅限研究用
-
- 状态
- Liquid
- 缓冲液
- PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store at -20°C. Avoid freeze / thaw cycles.
-
- 抗原
- FZR1 (Fizzy/cell Division Cycle 20 Related 1 (FZR1))
- 别名
- FZR1 (FZR1 产品)
- 别名
- CDH1-C antibody, FYR antibody, FZR antibody, CDH1 antibody, fzr1 antibody, CDC20C antibody, FZR2 antibody, HCDH antibody, HCDH1 antibody, AW108046 antibody, Cdh1 antibody, Fyr antibody, zgc:55450 antibody, fizzy and cell division cycle 20 related 1 antibody, fizzy/cell division cycle 20 related 1 antibody, fizzy-related protein homolog antibody, fizzy/cell division cycle 20 related 1 (Drosophila) antibody, fizzy/cell division cycle 20 related 1a antibody, Fzr1 antibody, CDH1-C antibody, FZR1 antibody, LOC100027495 antibody, LOC100179951 antibody, fzr1a antibody
- 背景
- Substrate-specific adapter for the anaphase promoting complex/cyclosome (APC/C E3 ubiquitin-protein ligase complex. Associates with the APC/C in late mitosis, in replacement of CDC20, and activates the APC/C during anaphase and telophase. The APC/C remains active in degrading substrates to ensure that positive regulators of the cell cycle do not accumulate prematurely. At the G1/S transition FZR1 is phosphorylated, leading to its dissociation from the APC/C. Following DNA damage, it is required for the G2 DNA damage checkpoint: its dephosphorylation and reassociation with the APC/C leads to the ubiquitination of PLK1, preventing entry into mitosis. Acts as an adapter for APC/C to target the DNA-end resection factor RBBP8/CtIP for ubiquitination and subsequent proteasomal degradation. Through the regulation of RBBP8/CtIP protein turnover, may play a role in DNA damage response, favoring DNA double-strand repair through error-prone non-homologous end joining (NHEJ over error-free, RBBP8-mediated homologous recombination (HR.,FZR1,CDC20C,CDH1,FZR,FZR2,HCDH,HCDH1,Cell Biology & Developmental Biology,Ubiquitin,Ubiquitin-Proteasome Signaling Pathway,FZR1
- 分子量
- 44 kDa/54 kDa/55 kDa
- 基因ID
- 51343
- UniProt
- Q9UM11
- 途径
- DNA Replication, Synthesis of DNA
-
You are here:
