FZR1 产品
(Fizzy/cell Division Cycle 20 Related 1 (FZR1))
Categories
Key regulator of ligase activity of the anaphase promoting complex/cyclosome (APC/C), which confers substrate specificity upon the complex. Associates with the APC/C in late mitosis, in replacement of CDC20, and activates the APC/C during anaphase and telophase. The APC/C remains active in degrading substrates to ensure that positive regulators of the cell cycle do not accumulate prematurely. At the G1/S transition FZR1 is phosphorylated, leading to its dissociation from the APC/C. Following DNA damage, it is required for the G2 DNA damage leads to the ubiquitination of PLK1, preventing entry into mitosis (By similarity).
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Featured FZR1 Categories
Recommended FZR1 抗体
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, ELISA, IHC (p), PLA
Validations
- (5)
Cat. No.
ABIN526652
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rat, Zebrafish (Danio rerio)
Application
WB
Validations
- (1)
- (5)
Cat. No.
ABIN2784494
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human, Mouse
Application
WB, ELISA, IF (cc), IF (p), IHC (p), ICC, IHC (fro)
Validations
- (3)
Cat. No.
ABIN1714172
Quantity
100 μL
Datasheet
Datasheet
Recommended FZR1 ELISA试剂盒
Recommended FZR1 蛋白
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1354593
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1354595
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Tobacco (Nicotiana tabacum)
Validations
- (1)
Cat. No.
ABIN3092674
Quantity
1 mg
Datasheet
Datasheet
Latest Publications for our FZR1 Products
: "APC-Cdh1 Regulates Neuronal Apoptosis Through Modulating Glycolysis and Pentose-Phosphate Pathway After Oxygen-Glucose Deprivation and Reperfusion." in: Cellular and molecular neurobiology, Vol. 39, Issue 1, pp. 123-135, (2019) (PubMed).: "Hippo signaling is intrinsically regulated during cell cycle progression by APC/CCdh1." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 116, Issue 19, pp. 9423-9432, (2019) (PubMed).
: "Inhibition of neddylation causes meiotic arrest in mouse oocyte." in: Cell cycle (Georgetown, Tex.), Vol. 18, Issue 11, pp. 1254-1267, (2019) (PubMed).
: "G1/S phase progression is regulated by PLK1 degradation through the CDK1/βTrCP axis." in: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 31, Issue 7, pp. 2925-2936, (2017) (PubMed).
: "Aβ Induces Excitotoxicity Mediated by APC/C-Cdh1 Depletion That Can Be Prevented by Glutaminase Inhibition Promoting Neuronal Survival." in: Scientific reports, Vol. 6, pp. 31158, (2016) (PubMed).
: "Downregulation of Cdh1 signalling in spinal dorsal horn contributes to the maintenance of mechanical allodynia after nerve injury in rats." in: Molecular pain, Vol. 12, (2016) (PubMed).
: "Reduced methylation of PFKFB3 in cancer cells shunts glucose towards the pentose phosphate pathway." in: Nature communications, Vol. 5, pp. 3480, (2014) (PubMed).
Synonyms and alternative names related to FZR1
fizzy and cell division cycle 20 related 1 (Fzr1), fizzy/cell division cycle 20 related 1 (CDH1-C), fizzy and cell division cycle 20 related 1 (FZR1), fizzy-related protein homolog (LOC100027495), fizzy-related protein homolog (LOC100179951), fizzy/cell division cycle 20 related 1 (Drosophila) (Fzr1), fizzy/cell division cycle 20 related 1a (fzr1a), AW108046, CDC20C, CDH1, Cdh1, CDH1-C, FYR, Fyr, FZR, fzr1, FZR2, HCDH, HCDH1, zgc:55450Protein level used designations for FZR1
- fizzy-related protein homolog
- fizzy/cell division cycle 20 related 1 (Drosophila)
- fizzy-related protein FZR
- Fizzy-related protein-like protein
- fizzy/cell division cycle 20 related 1
- CDC20-like 1b
- CDC20-like protein 1
- cdh1/Hct1 homolog
- cell division cycle 20 related 1
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- G Antigen 1
- G Antigen 10
- G Antigen 12B
- G Antigen 12F
- G Antigen 12G
- G Antigen 12H
- G Antigen 12I
- G Antigen 12J
- G Antigen 13
- G Antigen 2A
- G Antigen 2C
- G Antigen 2D
- G Antigen 4
- G Antigen 5
- G Antigen 7
- G Kinase Anchoring Protein 1
- G Protein-Coupled Receptor 1
- G Protein-Coupled Receptor 110
- G Protein-Coupled Receptor 115
- G Protein-Coupled Receptor 116
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