FXYD5 产品
(FXYD Domain Containing Ion Transport Regulator 5 (FXYD5))
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This gene encodes a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. The approved human gene nomenclature for the family is FXYD-domain containing ion transport regulator. Mouse FXYD5 has been termed RIC (Related to Ion Channel). FXYD2, also known as the gamma subunit of the Na,K-ATPase, regulates the properties of that enzyme. FXYD1 (phospholemman), FXYD2 (gamma), FXYD3 (MAT-8), FXYD4 (CHIF), and FXYD5 (RIC) have been shown to induce channel activity in experimental expression systems. Transmembrane topology has been established for two family members (FXYD1 and FXYD2), with the N-terminus extracellular and the C-terminus on the cytoplasmic side of the membrane. This gene product, FXYD5, is a glycoprotein that functions in the up-regulation of chemokine production, and it is involved in the reduction of cell adhesion via its ability to down-regulate E-cadherin. It also promotes metastasis, and has been linked to a variety of cancers. Alternative splicing results in multiple transcript variants. [RefSeq curation by Kathleen J. Sweadner, Ph.D., sweadner@helix.mgh.harvard.edu., Sep 2009].
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Featured FXYD5 Categories
Recommended FXYD5 抗体
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Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human, Mouse, Saccharomyces cerevisiae
Application
WB
Validations
- (1)
- (3)
Cat. No.
ABIN2780210
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
ELISA, IHC
Validations
- (2)
Cat. No.
ABIN7153251
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA
Validations
- (2)
Cat. No.
ABIN184712
Quantity
100 μg
Datasheet
Datasheet
Recommended FXYD5 蛋白
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Reactivity
Source
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Quantity
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN7123022
Quantity
50 μg
Datasheet
Datasheet
Reactivity
Human
Source
Insect Cells
Validations
- (1)
Cat. No.
ABIN3080468
Quantity
1 mg
Datasheet
Datasheet
Reactivity
Mouse
Source
Insect Cells
Validations
- (1)
Cat. No.
ABIN3121251
Quantity
1 mg
Datasheet
Datasheet
Latest Publications for our FXYD5 Products
: "Fxyd5 activates the NF‑κB pathway and is involved in chondrocytes inflammation and extracellular matrix degradation." in: Molecular medicine reports, Vol. 25, Issue 4, (2022) (PubMed).: "FXYD5 modulates Na+ absorption and is increased in cystic fibrosis airway epithelia." in: American journal of physiology. Lung cellular and molecular physiology, Vol. 294, Issue 4, pp. L654-64, (2008) (PubMed).
: "Aberrant O-glycosylation inhibits stable expression of dysadherin, a carcinoma-associated antigen, and facilitates cell-cell adhesion." in: Glycobiology, Vol. 13, Issue 7, pp. 521-7, (2003) (PubMed).
: "Dysadherin, a cancer-associated cell membrane glycoprotein, down-regulates E-cadherin and promotes metastasis." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 99, Issue 1, pp. 365-70, (2002) (PubMed).
Synonyms and alternative names related to FXYD5
FXYD domain containing ion transport regulator 5 (FXYD5), FXYD domain-containing ion transport regulator 5 (Fxyd5), DYSAD, EF-8, FXYD5, IWU1, KCT1, OIT2, Oit2, PRO6241, RICProtein level used designations for FXYD5
- FXYD domain-containing ion transport regulator 5
- FXYD domain containing ion transport regulator 5
- dysadherin
- keratinocytes associated transmembrane protein 1
- ion channel homolog RIC
- oncoprotein induced transcript 2
- oncoprotein-induced protein 2
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