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BAX 抗体 (Internal Region)

Name: BAX 抗体 (Internal Region)
SKU: ABIN6260205
Availability: OutOfStock

BAX 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated

Western blot analysis on rat liver tissue lysate using Bax Antibody (BAX 抗体 (Internal Region))

ABIN6266500 staining lovo cells by ICC/IF. (BAX 抗体 (Internal Region))

IF/ICC

Western blot analysis on HepG2 cell lysate using Bax Antibody,The lane on the left is treated with the antigen-specific peptide. (BAX 抗体 (Internal Region))

3 images

(11 references)

产品编号 ABIN6260205

发货至: 中国

Datasheet as PDF

抗原 See all BAX 抗体

BAX (BCL2-Associated X Protein (BAX))
抗原表位
40

32

20

18

15

11

10

10

9

8

8

7

6

6

5

4

3

3

3

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
Internal Region
适用
259

156

143

46

31

27

25

18

17

10

9

5

3

3

3

2

1

1

1

1

1
人, 小鼠, 大鼠
宿主
170

97

4

2
兔
Compatible Secondaries
克隆类型
182

91
多克隆
标记
144

16

13

13

10

7

6

6

6

6

6

6

5

5

5

5

5

1

1

1

1

1

1

1

1

1
This BAX antibody is un-conjugated
应用范围
243

114

73

66

53

52

52

45

42

14

12

8

5

3

1

1

1

1

1

1

1

1

1
Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)

特异性

Bax Antibody detects endogenous levels of total Bax.

预测反应

Pig,Bovine,Horse,Rabbit,Dog

纯化方法

The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

免疫原

A synthesized peptide derived from human Bax, corresponding to a region within the internal amino acids.

亚型

IgG

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anti-BCL2-Associated X Protein (BAX) (AA 1-192) antibody
BAX 适用: 人 WB, ELISA, IF, IHC (p), PLA 宿主: 小鼠 Monoclonal 1F5-1B7 unconjugated

anti-BCL2-Associated X Protein (BAX) (AA 13-160) antibody
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anti-BCL2-Associated X Protein (BAX) (AA 41-76) antibody
BAX 适用: 人, 小鼠 WB, FACS 宿主: 兔 Polyclonal RB0952 unconjugated

应用备注

WB: 1:500-1:3000, IHC: 1:50-1:200, IF/ICC 1:200, ELISA(peptide) 1:20000-1:40000

限制

仅限研究用
状态

Liquid

浓度

1 mg/mL

缓冲液

Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, glycerol.

储存条件

-20 °C

储存方法

Store at -20 °C. Stable for 12 months from date of receipt.

有效期

12 months
Lu, Zhou, Hao, Li, Wang, Shu, Du, Zhu, Zhang, Yin: "The mTOR promotes oxidative stress-induced apoptosis of mesangial cells in diabetic nephropathy." in: Molecular and cellular endocrinology, Vol. 473, pp. 31-43, (2018) (PubMed).

Shao, Zhang, Ma, Lu, Meng, Li, Wang, Chen, Zhang, Han, Liu, Ma: "MicroRNA-139-5p affects cisplatin sensitivity in human nasopharyngeal carcinoma cells by regulating the epithelial-to-mesenchymal transition." in: Gene, Vol. 652, pp. 48-58, (2018) (PubMed).

Liu, Geng, Zhang, Wang, Zhang, Duan, Zhang: "Oligo-Porphyran Ameliorates Neurobehavioral Deficits in Parkinsonian Mice by Regulating the PI3K/Akt/Bcl-2 Pathway." in: Marine drugs, Vol. 16, Issue 3, (2018) (PubMed).

Zhou, Zhang, Liu, Lei, Liu, Jiao, Dang: "Altered Light Conditions Contribute to Abnormalities in Emotion and Cognition Through HINT1 Dysfunction in C57BL/6 Mice." in: Frontiers in behavioral neuroscience, Vol. 12, pp. 110, (2018) (PubMed).

Wang, Li, Chen, Luo, Gu, Wang, Wu, Xu et al.: "Baicalin extracted from Huangqin (Radix Scutellariae Baicalensis) induces apoptosis in gastric cancer cells by regulating B cell lymphoma (Bcl-2)/Bcl-2-associated X protein and activating caspase-3 ..." in: Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan, Vol. 37, Issue 2, pp. 229-5, (2018) (PubMed).

Liu, Zheng, Zhang, Wang, Yang, Bai, Dai: "Fucoxanthin Activates Apoptosis via Inhibition of PI3K/Akt/mTOR Pathway and Suppresses Invasion and Migration by Restriction of p38-MMP-2/9 Pathway in Human Glioblastoma Cells." in: Neurochemical research, Vol. 41, Issue 10, pp. 2728-2751, (2017) (PubMed).

Zhao, Deng, Xu, Zhang, Mi, Meng, Gou, Xu: "PirB Overexpression Exacerbates Neuronal Apoptosis by Inhibiting TrkB and mTOR Phosphorylation After Oxygen and Glucose Deprivation Injury." in: Cellular and molecular neurobiology, Vol. 37, Issue 4, pp. 707-715, (2017) (PubMed).

Gu, Yang, Qi, Mei, Chen, Song, Jing, Chen, He, Sun, Hu, Li, Wüthrich, Wu, Mei: "Olmesartan Prevents Microalbuminuria in db/db Diabetic Mice Through Inhibition of Angiotensin II/p38/SIRT1-Induced Podocyte Apoptosis." in: Kidney & blood pressure research, Vol. 41, Issue 6, pp. 848-864, (2017) (PubMed).

Chen, Wu, Gan, Liu, Lv, Shen, Dai, Xu: "Iridoid glycoside from Cornus officinalis ameliorated diabetes mellitus-induced testicular damage in male rats: Involvement of suppression of the AGEs/RAGE/p38 MAPK signaling pathway." in: Journal of ethnopharmacology, Vol. 194, pp. 850-860, (2017) (PubMed).

Liu, Liu, He, Zhang, Liu, Wang, Qiu, Xu, Xiang, Lv: "Differential gene and lncRNA expression in the lower thoracic spinal cord following ischemia/reperfusion-induced acute kidney injury in rats." in: Oncotarget, Vol. 8, Issue 32, pp. 53465-53481, (2017) (PubMed).

Tian, Wang, Zhang, Luo, Jiang, Zhang, Mei, Wu, Wu, Peng, Long, Luo, Guo: "Phosphoprotein Gene Contributes to the Enhanced Apoptosis Induced by Wild-Type Rabies Virus GD-SH-01 In Vitro." in: Frontiers in microbiology, Vol. 8, pp. 1697, (2017) (PubMed).
抗原

BAX (BCL2-Associated X Protein (BAX))

别名

BAX (BAX 产品)

别名

BAX-ALPHA antibody, bax-A antibody, xBax antibody, xlbax antibody, BAX antibody, bax antibody, fj16e01 antibody, wu:fc50b10 antibody, wu:fj16e01 antibody, BCL2L4 antibody, zgc:112983 antibody, BCL2 associated X, apoptosis regulator antibody, BCL2-associated X protein L homeolog antibody, BCL2-associated X protein antibody, bcl2-associated X protein, a antibody, bcl2-associated X protein, b antibody, BAX antibody, bax.L antibody, bax antibody, baxa antibody, Bax antibody, baxb antibody

背景

Description: Plays a role in the mitochondrial apoptotic process. Under normal conditions, BAX is largely cytosolic via constant retrotranslocation from mitochondria to the cytosol mediated by BCL2L1/Bcl-xL, which avoids accumulation of toxic BAX levels at the mitochondrial outer membrane (MOM) (PubMed:21458670). Under stress conditions, undergoes a conformation change that causes translocation to the mitochondrion membrane, leading to the release of cytochrome c that then triggers apoptosis. Promotes activation of CASP3, and thereby apoptosis.
Gene: BAX

分子量

21kDa

基因ID

581

UniProt

Q07812

途径

p53 Pathway, PI3K-Akt Signaling, Apoptosis, Caspase Cascade in Apoptosis, Positive Regulation of Endopeptidase Activity, Unfolded Protein Response