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BAX 抗体 (AA 41-76)

Name: BAX 抗体 (AA 41-76)
SKU: ABIN388094
Availability: OutOfStock

BAX 适用: 人, 小鼠 WB, FACS 宿主: 兔 Polyclonal RB0952 unconjugated

All lanes : Anti-Bax Antibody (BH3 Domain Specific) at 1:2000 dilution Lane 1: Raji whole cell lysate Lane 2: SH-SH5Y whole cell lysate Lane 3: HT-1080 whole cell lysate Lane 4: NIH/3T3 whole cell lysate Lane 5: whole cell lysate Lysates/proteins at 20 μg per lane. (BAX 抗体 (AA 41-76))

Overlay histogram showing HeLa cells stained with (ABIN388094 and ABIN2837860)(green line). (BAX 抗体 (AA 41-76))

FACS

All lanes : Anti-Bax Antibody (BH3) at 1:2000 dilution Lane 1: HT-1080 whole cell lysate Lane 2: whole cell lysate Lane 3: Raji whole cell lysate Lane 4: SH-SY5Y whole cell lysate Lysates/proteins at 20 μg per lane. (BAX 抗体 (AA 41-76))

All lanes : Anti-Bax Antibody (BH3 Domain Specific) at 1:2000 dilution Lane 1: HT-1080 whole cell lysate Lane 2: Raji whole cell lysate Lane 3: SH-SY5Y whole cell lysate Lane 4: THP-1 whole cell lysate Lane 5: NIH/3T3 whole cell lysate Lane 6: whole cell lysate Lysates/proteins at 20 μg per lane. (BAX 抗体 (AA 41-76))

Anti-Bax Antibody (BH3) at 1:2000 dilution + mouse spleen lysate Lysates/proteins at 20 μg per lane. (BAX 抗体 (AA 41-76))

5 images

(8 references)

产品编号 ABIN388094

发货至: 中国

Datasheet as PDF

抗原 See all BAX 抗体

BAX (BCL2-Associated X Protein (BAX))
抗原表位
40

32

20

18

15

11

10

10

8

8

8

7

6

6

5

4

3

3

3

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
AA 41-76
适用
258

155

143

46

31

27

25

18

17

10

9

5

3

3

3

2

1

1

1

1

1
人, 小鼠
宿主
169

97

4

2
兔
Compatible Secondaries
克隆类型
181

91
多克隆
标记
143

16

13

13

10

7

6

6

6

6

6

6

5

5

5

5

5

1

1

1

1

1

1

1

1

1
This BAX antibody is un-conjugated
应用范围
242

114

72

66

53

52

52

45

42

14

12

8

5

3

1

1

1

1

1

1

1

1

1
Western Blotting (WB), Flow Cytometry (FACS)

预测反应

B

纯化方法

This antibody is purified through a protein A column, followed by peptide affinity purification.

免疫原

This Bax antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 41-76 amino acids from human Bax.

克隆位点

RB0952

亚型

Ig Fraction

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anti-BCL2-Associated X Protein (BAX) (AA 1-158) antibody
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anti-BCL2-Associated X Protein (BAX) (AA 1-192) antibody
BAX 适用: 人 WB, ELISA, IF, IHC (p), PLA 宿主: 小鼠 Monoclonal 1F5-1B7 unconjugated

anti-BCL2-Associated X Protein (BAX) (AA 13-160) antibody
BAX 适用: 人 WB, ELISA, IHC, FACS, ICC, Neut 宿主: 小鼠 Monoclonal 4H9B11 unconjugated

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anti-BCL2-Associated X Protein (BAX) (AA 41-76) antibody
BAX 适用: 人 WB, ELISA, IHC, FACS 宿主: 兔 Polyclonal unconjugated

应用备注

WB: 1:2000. WB: 1:2000. WB: 1:2000. WB: 1:2000. FC: 1:25

限制

仅限研究用
状态

Liquid

缓冲液

Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

4 °C,-20 °C

储存方法

Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

有效期

6 months
Cui, Lin, Shi, Pan: "Hypoxic postconditioning attenuates apoptosis via inactivation of adenosine A2a receptor through NDRG3-Raf-ERK pathway." in: Biochemical and biophysical research communications, Vol. 491, Issue 2, pp. 277-284, (2017) (PubMed).

Lin, Ma, Wang, Zhao, Liu, Pu, Hu, Hu, Shao: "Edaravone ameliorates compression-induced damage in rat nucleus pulposus cells." in: Life sciences, Vol. 189, pp. 76-83, (2017) (PubMed).

Hu, Kuo, Senadi, Chang, Wang: "Photodynamic Therapy Using Indolines-Fused-Triazoles Induces Mitochondrial Apoptosis in Human Non-Melanoma BCC Cells." in: Anticancer research, Vol. 37, Issue 10, pp. 5499-5505, (2017) (PubMed).

Wang, Wang, Li, Yang, Xing, Chen, Xu: "HMGB1 knockdown effectively inhibits the progression of rectal cancer by suppressing HMGB1 expression and promoting apoptosis of rectal cancer cells." in: Molecular medicine reports, Vol. 14, Issue 1, pp. 1026-32, (2016) (PubMed).

Soni, Adebiyi: "Early septic insult in neonatal pigs increases serum and urinary soluble Fas ligand and decreases kidney function without inducing significant renal apoptosis." in: Renal failure, pp. 1-12, (2016) (PubMed).

Li, Wang, Wang, Gao, Zhang, Lu: "Oridonin phosphate-induced autophagy effectively enhances cell apoptosis of human breast cancer cells." in: Medical oncology (Northwood, London, England), Vol. 32, Issue 1, pp. 365, (2014) (PubMed).

Gavathiotis, Reyna, Davis, Bird, Walensky: "BH3-triggered structural reorganization drives the activation of proapoptotic BAX." in: Molecular cell, Vol. 40, Issue 3, pp. 481-92, (2010) (PubMed).

Granado, Gangoiti, Ouro, Arana, Gómez-Muñoz: "Ceramide 1-phosphate inhibits serine palmitoyltransferase and blocks apoptosis in alveolar macrophages." in: Biochimica et biophysica acta, Vol. 1791, Issue 4, pp. 263-72, (2009) (PubMed).
抗原

BAX (BCL2-Associated X Protein (BAX))

别名

Bax (BAX 产品)

别名

BAX-ALPHA antibody, bax-A antibody, xBax antibody, xlbax antibody, BAX antibody, bax antibody, fj16e01 antibody, wu:fc50b10 antibody, wu:fj16e01 antibody, BCL2L4 antibody, zgc:112983 antibody, BCL2 associated X, apoptosis regulator antibody, BCL2-associated X protein L homeolog antibody, BCL2-associated X protein antibody, bcl2-associated X protein, a antibody, bcl2-associated X protein, b antibody, BAX antibody, bax.L antibody, bax antibody, baxa antibody, Bax antibody, baxb antibody

背景

Bax belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. Bax forms a heterodimer with BCL2, and functions as an apoptotic activator. This protein is reported to interact with, and increase the opening of, the mitochondrial voltage-dependent anion channel (VDAC), which leads to the loss in membrane potential and the release of cytochrome c. The expression of the Bax gene is regulated by the tumor suppressor P53 and has been shown to be involved in P53-mediated apoptosis.

分子量

21184

基因ID

581

NCBI登录号

NP_004315, NP_620116, NP_620118, NP_620119

UniProt

Q07812

途径

p53 Pathway, PI3K-Akt Signaling, Apoptosis, Caspase Cascade in Apoptosis, Positive Regulation of Endopeptidase Activity, Unfolded Protein Response