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FZR1 抗体 (N-Term)
FZR1
适用: 人
WB
宿主: 兔
Polyclonal
unconjugated
FZR1抗体详情
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抗原
See all FZR1 抗体
FZR1
(Fizzy/cell Division Cycle 20 Related 1 (FZR1))
抗原表位
All epitopes for FZR1 抗体
N-Term
适用
All reactivities for FZR1 抗体
人
宿主
All hosts for FZR1 抗体
兔
克隆类型
All clonalities for FZR1 抗体
多克隆
标记
All conjugates for FZR1 抗体
This FZR1 antibody is un-conjugated
应用范围
All applications for FZR1 抗体
Western Blotting (WB)
序列
SKHGDRFIPS RAGANWSVNF HRINENEKSP SQNRKAKDAT SDNGKDGLAY
产品特性
This is a rabbit polyclonal antibody against FZR. It was validated on Western Blot.
纯化方法
Affinity Purified
免疫原
The immunogen is a synthetic peptide directed towards the N-terminal region of Human FZR
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使用细节
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应用备注
Optimal working dilution should be determined by the investigator.
限制
仅限研究用
贮存及处理
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状态
Liquid
缓冲液
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
储存液
Sodium azide
注意事项
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
储存条件
-20 °C
储存方法
For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
FZR1目标详情
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抗原
FZR1
(Fizzy/cell Division Cycle 20 Related 1 (FZR1))
别名
FZR (FZR1 产品 )
别名
CDH1-C antibody, FYR antibody, FZR antibody, CDH1 antibody, fzr1 antibody, CDC20C antibody, FZR2 antibody, HCDH antibody, HCDH1 antibody, AW108046 antibody, Cdh1 antibody, Fyr antibody, zgc:55450 antibody, fizzy and cell division cycle 20 related 1 antibody, fizzy/cell division cycle 20 related 1 antibody, fizzy-related protein homolog antibody, fizzy/cell division cycle 20 related 1 (Drosophila) antibody, fizzy/cell division cycle 20 related 1a antibody, Fzr1 antibody, CDH1-C antibody, FZR1 antibody, LOC100027495 antibody, LOC100179951 antibody, fzr1a antibody
背景
FZR is a key regulator of ligase activity of the anaphase promoting complex/cyclosome (APC/C), which confers substrate specificity upon the complex. Associates with the APC/C in late mitosis, in replacement of CDC20, and activates the APC/C during anaphase and telophase. The APC/C remains active in degrading substrates to ensure that positive regulators of the cell cycle do not accumulate prematurely. At the G1/S transition FZR1 is phosphorylated, leading to its dissociation from the APC/C. Following DNA damage, it is required for the G2 DNA damage checkpoint: its dephosphorylation and reassociation with the APC/C leads to the ubiquitination of PLK1, preventing entry into mitosis. Alias Symbols: FZR1, CDH1, FYR, FZR, KIAA1242, Protein Interaction Partner: ZC3HC1, CDC25A, CCNB1, UBE2S, UBE2C, PTTG1, UBE2D2, TP53, CDR2, UBE2K, ANAPC4, PDS1, STAU1, CDK2, CDC27, RACGAP1, FOXM1, HECW2, PHF8, BTRC, CCNA1, UBC, SOX2, SKP2, PLK1, CUL1, CUEDC2, CDC20, kif22, SIRT2, CLSPN, ANAPC11, CDC14B, VHL, PTEN, EYA1, DAXX, BUB Protein Size: 496
基因ID
51343
NCBI登录号
XP_005259630
UniProt
Q9UM11
途径
DNA Replication , Synthesis of DNA
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