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c-MET 抗体 (pTyr1234)

MET 适用: 人, 小鼠, 大鼠 WB 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN498738
发货至: 中国
  • 抗原 See all c-MET (MET) 抗体
    c-MET (MET) (Met Proto-Oncogene (MET))
    抗原表位
    • 49
    • 35
    • 28
    • 21
    • 16
    • 12
    • 11
    • 8
    • 7
    • 7
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    • 2
    • 2
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    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    pTyr1234
    适用
    • 251
    • 144
    • 98
    • 8
    • 6
    • 4
    • 4
    • 4
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    人, 小鼠, 大鼠
    宿主
    • 222
    • 39
    • 3
    • 2
    克隆类型
    • 210
    • 56
    多克隆
    标记
    • 132
    • 20
    • 13
    • 12
    • 9
    • 9
    • 9
    • 9
    • 9
    • 9
    • 8
    • 7
    • 3
    • 3
    • 3
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    This c-MET antibody is un-conjugated
    应用范围
    • 182
    • 105
    • 51
    • 43
    • 31
    • 27
    • 26
    • 24
    • 15
    • 8
    • 8
    • 7
    • 4
    • 4
    • 1
    • 1
    • 1
    Western Blotting (WB)
    特异性
    This antibody detects endogenous levels of Met protein only when phosphorylated at Tyr1234
    交叉反应 (详细)
    Species reactivity (expected):Mouse and Rat.
    Species reactivity (tested):Human.
    纯化方法
    Affinity Chromatography using epitope-specific immunogen
    Top Product
    Discover our top product MET Primary Antibody
  • 应用备注
    Western Blot: 1/500 - 1/1000.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    限制
    仅限研究用
  • 浓度
    1.0 mg/mL
    缓冲液
    PBS, pH ~7.2, 0.05 % sodium azide
    注意事项
    Avoid repeated freezing and thawing.
    储存条件
    4 °C/-20 °C
    储存方法
    Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
  • 抗原
    c-MET (MET) (Met Proto-Oncogene (MET))
    别名
    HGF Receptor (MET 产品)
    别名
    AUTS9 antibody, HGFR antibody, RCCP2 antibody, c-Met antibody, AI838057 antibody, HGF antibody, Par4 antibody, Hgfr antibody, c-met antibody, MET antibody, C-MET antibody, met antibody, met-A antibody, MET proto-oncogene, receptor tyrosine kinase antibody, met proto-oncogene antibody, MET proto-oncogene, receptor tyrosine kinase L homeolog antibody, MET antibody, Met antibody, met.L antibody
    背景
    The c-Met oncogene was originally isolated from a chemical carcinogen-treated human osteogenic sarcoma cell line by transfection analysis in NIH/3T3 cells. The Met protooncogene product was identified as a transmembrane receptorlike protein with tyrosine kinase activity that is expressed in many tissues. A high proportion of spontaneous NIH/3T3 transformants overexpress c-Met and by transfection analysis the c-Met proto-oncogene has been shown to exhibit transforming activity.Tyrosine phosphorylation of apparently normal Met protein has also been observed in certain human gastric carcinoma cell lines. Tyrosine phosphorylation enhances the receptor kinase activity, while serine phosphorylation of Met on residue 985 has an inhibitory effect. The c-Met gene product has been identified as the cell surface receptor for hepatocyte growth factor, a plasminogen-like protein thought to be a humoral mediator of liver regeneration.Synonyms: HGF/SF receptor, Hepatocyte growth factor receptor, MET, Met proto-oncogene tyrosine kinase, Scatter factor receptor, c-Met
    分子量
    approx. 170 kDa
    基因ID
    4233
    NCBI登录号
    NP_000236
    UniProt
    P08581
    途径
    RTK signaling, Carbohydrate Homeostasis, Synaptic Membrane, Signaling of Hepatocyte Growth Factor Receptor
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