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c-MET 抗体 (Tyr1003)

Name: c-MET 抗体 (Tyr1003)
Brand: antibodies-online
SKU: ABIN7179985
Availability: OutOfStock

MET 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated

Western blot analysis of extracts from HepG2 cells, using c-Met (Ab-1003) antibody. (c-MET 抗体 (Tyr1003))

Immunofluorescence analysis of A549 cells, using c-Met (Ab-1003) antibody. (c-MET 抗体 (Tyr1003))

Immunohistochemistry analysis of paraffin-embedded human brain tissue using c-Met (Ab-1003) antiobdy. (c-MET 抗体 (Tyr1003))

IHC

3 images

产品编号 ABIN7179985

发货至: 中国

Datasheet as PDF

抗原 See all c-MET (MET) 抗体

c-MET (MET) (Met Proto-Oncogene (MET))
抗原表位
49

35

28

21

16

12

11

8

7

7

7

6

5

5

4

4

3

3

3

3

3

3

2

2

2

2

2

2

2

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
Tyr1003
适用
250

144

98

8

6

4

4

4

2

2

2

1

1

1

1
人
宿主
221

39

3

2
兔
Compatible Secondaries
克隆类型
209

56
多克隆
标记
131

20

13

12

9

9

9

9

9

9

8

7

3

3

3

3

3

1

1

1

1

1
This c-MET antibody is un-conjugated
应用范围
181

104

51

42

30

27

26

24

15

8

8

7

4

4

1

1

1
Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

交叉反应

人, 小鼠, 大鼠

纯化方法

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

免疫原

Synthesized non-phosphopeptide derived from Human c-Met around the phosphorylation site of tyrosine 1003 (V-D-Y(p)-R-A).

亚型

IgG

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MET 适用: 人 WB, ELISA, IHC, FACS, ICC 宿主: 小鼠 Monoclonal 5E9B7 unconjugated

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anti-Met Proto-Oncogene (MET) (pTyr1349) antibody
MET 适用: 人, 小鼠, 大鼠 WB, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated

anti-Met Proto-Oncogene (MET) (pTyr1003) antibody
MET 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated

应用备注

WB:1:500-1:3000, IHC:1:50-1:100, IF:1:100-1:500,

限制

仅限研究用
状态

Liquid

缓冲液

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

-20 °C,-80 °C

储存方法

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
抗原

c-MET (MET) (Met Proto-Oncogene (MET))

别名

MET (MET 产品)

别名

AUTS9 antibody, HGFR antibody, RCCP2 antibody, c-Met antibody, AI838057 antibody, HGF antibody, Par4 antibody, Hgfr antibody, c-met antibody, MET antibody, C-MET antibody, met antibody, met-A antibody, MET proto-oncogene, receptor tyrosine kinase antibody, met proto-oncogene antibody, MET proto-oncogene, receptor tyrosine kinase L homeolog antibody, MET antibody, Met antibody, met.L antibody

背景

Background: Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of these downstream effectors by MET leads to the activation of several signaling cascades including the RAS-ERK, PI3 kinase-AKT, or PLCgamma-PKC. The RAS-ERK activation is associated with the morphogenetic effects while PI3K/AKT coordinates prosurvival effects. During embryonic development, MET signaling plays a role in gastrulation, development and migration of muscles and neuronal precursors, angiogenesis and kidney formation. In adults, participates in wound healing as well as organ regeneration and tissue remodeling. Promotes also differentiation and proliferation of hematopoietic cells. Acts as a receptor for Listeria internalin inlB, mediating entry of the pathogen into cells.

Hillier L.W., Nature 424:157-164(2003).
Wang D., J. Biol. Chem. 277:36216-36222(2002).
Giordano S., Nat. Cell Biol. 4:720-724(2002)
Aliases: AUTS9 antibody, c met antibody, D249 antibody, Hepatocyte growth factor receptor antibody, HGF antibody, HGF receptor antibody, HGF/SF receptor antibody, HGFR antibody, MET antibody, Met proto oncogene antibody, Met proto oncogene tyrosine kinase antibody, MET proto oncogene, receptor tyrosine kinase antibody, Met proto-oncogene (hepatocyte growth factor receptor) antibody, Met proto-oncogene antibody, Met protooncogene antibody, MET_HUMAN antibody, Oncogene MET antibody, Par4 antibody, Proto-oncogene c-Met antibody, RCCP2 antibody, Scatter factor receptor antibody, SF receptor antibody, Tyrosine-protein kinase Met antibody

UniProt

P08581

途径

RTK signaling, Carbohydrate Homeostasis, Synaptic Membrane, Signaling of Hepatocyte Growth Factor Receptor