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- 抗原 See all DIO3 抗体
- DIO3 (Deiodinase, Iodothyronine, Type III (DIO3))
- 适用
- 人, 大鼠, 小鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This DIO3 antibody is un-conjugated
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应用范围
- Western Blotting (WB)
- 特异性
- This antibody detects endogenous levels of DIO3 protein. (region surrounding Glu66)
- 交叉反应 （详细）
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Species reactivity (expected):Mouse and Rat.
Species reactivity (tested):Human. - 纯化方法
- Affinity Chromatography using epitope-specific immunogen.
- Top Product
- Discover our top product DIO3 Primary Antibody
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anti-Deiodinase, Iodothyronine, Type III (DIO3) (AA 37-169) antibody
DIO3 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Deiodinase, Iodothyronine, Type III (DIO3) (AA 51-150) antibodyDIO3 适用: 人 WB, ELISA, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Deiodinase, Iodothyronine, Type III (DIO3) (AA 250-278), (C-Term) antibodyDIO3 适用: 人, 大鼠 WB, IHC, IHC (p) 宿主: 兔 Polyclonal RB24089 unconjugated
anti-Deiodinase, Iodothyronine, Type III (DIO3) (AA 250-300) antibodyDIO3 适用: 大鼠, 小鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-Deiodinase, Iodothyronine, Type III (DIO3) (Internal Region) antibodyDIO3 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Deiodinase, Iodothyronine, Type III (DIO3) (AA 50-115) antibodyDIO3 适用: 人 ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Deiodinase, Iodothyronine, Type III (DIO3) (Internal Region) antibodyDIO3 适用: 人, 大鼠, 小鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Deiodinase, Iodothyronine, Type III (DIO3) (AA 70-170) antibodyDIO3 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Deiodinase, Iodothyronine, Type III (DIO3) (AA 250-278), (C-Term) antibodyDIO3 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Deiodinase, Iodothyronine, Type III (DIO3) (AA 249-278), (C-Term) antibodyDIO3 适用: 人 WB, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
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- 应用备注
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Western Blot: 1/500 - 1/1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. - 限制
- 仅限研究用
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- 浓度
- 1.0 mg/mL
- 缓冲液
- Phosphate Buffered Saline (PBS), pH ~7.2, 0.05 % Sodium Azide
- 储存液
- Sodium azide
- 注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 注意事项
- Avoid repeated freezing and thawing.
- 储存条件
- 4 °C/-20 °C
- 储存方法
- Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
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- 抗原
- DIO3 (Deiodinase, Iodothyronine, Type III (DIO3))
- 别名
- DIO3 (DIO3 产品)
- 别名
- 5DIII antibody, DIOIII antibody, txdi3 antibody, dioiii antibody, XL-15 antibody, itdi3 antibody, D3 antibody, TXDI3 antibody, iodothyronine deiodinase 3 antibody, deiodinase, iodothyronine, type 3 antibody, deiodinase, iodothyronine, type III antibody, deiodinase, iodothyronine type III antibody, deiodinase, iodothyronine, type 3 L homeolog antibody, DIO3 antibody, dio3 antibody, Dio3 antibody, dio3.L antibody
- 背景
- DIO3 (deiodinase, iodothyronine, type III), also known as D3, 5DIII, TXDI3 or DIOIII, is a single-pass type II membrane protein that belongs to the iodothyronine deiodinase family of proteins. Members of the iodothyronine deiodinase family play an important role in thyroid hormone metabolism. Expressed in placenta and various fetal tissues, DIO3 localizes to the cell membrane and plays an important role regulating the activity of thyroid hormones during morphogenesis. More specifically, DIO3 functions as the major physiologic inactivator of thyroid hormones, catalyzing the inner-ring deiodination (the removal of iodine groups) of 3,5,3',5'-tetraiodothyronine (T4) and 3,5,3'-triiodothyronine (T3) to their inactive metabolites 3,3',5'-triiodothyronine (RT3 or reverse T3) and 3,3'-diiodothyronine (T2), respectively. Through its ability to inactivate thyroid hormones, DIO3 effects thermoregulation, gene expression and energy metabolism, as well as a number of other important reactions in cell maintenance and differentiation.Synonyms: 5DIII, DIOIII, ITDI3, TXDI3, Type 3 DI, Type III iodothyronine deiodinase, Type-III 5'-deiodinase
- 分子量
- approx. 30 kDa
- 基因ID
- 1735
- NCBI登录号
- NP_001353
- UniProt
- P55073
- 途径
- Hormone Activity
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