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IKBKB 抗体

Name: IKBKB 抗体
SKU: ABIN387826
Availability: OutOfStock

IKBKB 适用: 人 WB 宿主: 小鼠 Monoclonal 62AT216 unconjugated

All lanes : Anti-IKK beta Antibody at 1:4000 dilution Lane 1: HL-60 whole cell lysates Lane 2: Hela whole cell lysates Lane 3: Jurkat whole cell lysates Lysates/proteins at 20 μg per lane. (IKBKB 抗体)

1 image

(6 references)

产品编号 ABIN387826

发货至: 中国

Datasheet as PDF

抗原 See all IKBKB 抗体

IKBKB (Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase beta (IKBKB))
适用
283

113

72

8

7

4

4

3

3

3

1

1
人
宿主
289

19

1
小鼠
Compatible Secondaries
克隆类型
285

24
单克隆
标记
132

24

24

23

18

16

7

7

7

7

7

7

6

6

6

6

6
This IKBKB antibody is un-conjugated
应用范围
160

117

107

80

80

31

29

25

22

20

14

10

4

3

1

1
Western Blotting (WB)

纯化方法

This antibody is purified through a protein G column, followed by dialysis against PBS.

免疫原

This IKK beta antibody was raised using purified His-tagged recombinant full length human IKK beta.

克隆位点

62AT216

亚型

IgG1

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anti-Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase beta (IKBKB) (AA 630-730) antibody
IKBKB 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated

anti-Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase beta (IKBKB) (pTyr199) antibody
IKBKB 适用: 人, 小鼠, 大鼠, 猴 ELISA, WB, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated

anti-Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase beta (IKBKB) (C-Term) antibody
IKBKB 适用: 人 WB, IF, IHC (p), ICC 宿主: 兔 Polyclonal unconjugated

anti-Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase beta (IKBKB) antibody
IKBKB 适用: 人, 小鼠, 大鼠 IHC, IF 宿主: 兔 Polyclonal unconjugated

anti-Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase beta (IKBKB) (AA 3-120) antibody
IKBKB 适用: 人 ELISA, WB, PLA 宿主: 小鼠 Monoclonal 1A3 unconjugated

anti-Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase beta (IKBKB) antibody
IKBKB 适用: 人 WB, IHC, IF 宿主: 兔 Monoclonal unconjugated

anti-Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase beta (IKBKB) antibody
IKBKB 适用: 人 ELISA, WB, IHC, IF 宿主: 兔 Polyclonal unconjugated

anti-Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase beta (IKBKB) (AA 395-588) antibody
IKBKB 适用: 人 ELISA, WB, IHC, IF 宿主: 兔 Polyclonal unconjugated

anti-Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase beta (IKBKB) antibody
IKBKB 适用: 人 ELISA, WB, IHC, IF 宿主: 兔 Monoclonal 3E1 unconjugated Recombinant Antibody

anti-Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase beta (IKBKB) (AA 3-120) antibody
IKBKB 适用: 人 ELISA, WB, IF 宿主: 小鼠 Monoclonal 3C12 unconjugated

应用备注

WB: 1:100~500. WB: 1:4000

限制

仅限研究用
状态

Liquid

缓冲液

Purified monoclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

4 °C,-20 °C

储存方法

Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C.

有效期

6 months
Boisson, Laplantine, Dobbs, Cobat, Tarantino, Hazen, Lidov, Hopkins, Du, Belkadi, Chrabieh, Itan, Picard, Fournet, Eibel, Tsitsikov, Pai, Abel, Al-Herz, Casanova, Israel, Notarangelo: "Human HOIP and LUBAC deficiency underlies autoinflammation, immunodeficiency, amylopectinosis, and lymphangiectasia." in: The Journal of experimental medicine, Vol. 212, Issue 6, pp. 939-51, (2015) (PubMed).

Tarantino, Tinevez, Crowell, Boisson, Henriques, Mhlanga, Agou, Israël, Laplantine: "TNF and IL-1 exhibit distinct ubiquitin requirements for inducing NEMO-IKK supramolecular structures." in: The Journal of cell biology, Vol. 204, Issue 2, pp. 231-45, (2014) (PubMed).

Boisson, Laplantine, Prando, Giliani, Israelsson, Xu, Abhyankar, Israël, Trevejo-Nunez, Bogunovic, Cepika, MacDuff, Chrabieh, Hubeau, Bajolle, Debré, Mazzolari, Vairo, Agou, Virgin, Bossuyt, Rambaud et al.: "Immunodeficiency, autoinflammation and amylopectinosis in humans with inherited HOIL-1 and LUBAC deficiency. ..." in: Nature immunology, Vol. 13, Issue 12, pp. 1178-86, (2012) (PubMed).

Fan, Meng, Laterra, Rosen: "Role of Src signal transduction pathways in scatter factor-mediated cellular protection." in: The Journal of biological chemistry, Vol. 284, Issue 12, pp. 7561-77, (2009) (PubMed).

Lobry, Lopez, Israël, Weil: "Negative feedback loop in T cell activation through IkappaB kinase-induced phosphorylation and degradation of Bcl10." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 104, Issue 3, pp. 908-13, (2007) (PubMed).

Panopoulos, Harraz, Engelhardt, Zandi et al.: "Iron-mediated H2O2 production as a mechanism for cell type-specific inhibition of tumor necrosis factor alpha-induced but not interleukin-1beta-induced IkappaB kinase complex/nuclear factor-kappaB ..." in: The Journal of biological chemistry, Vol. 280, Issue 4, pp. 2912-23, (2005) (PubMed).
抗原

IKBKB (Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase beta (IKBKB))

别名

IKK beta (IKBKB 产品)

别名

ikk-beta antibody, ikk2 antibody, ikkb antibody, ikkbeta antibody, IKBKB antibody, IKKB antibody, CG4201 antibody, DIK antibody, DLAK antibody, DmIKK antibody, DmIKKBeta antibody, DmIKKb antibody, DmIKKbeta antibody, DmIkkbeta antibody, Dmel\\CG4201 antibody, Dmikkb antibody, Dmikkbeta antibody, IK antibody, IKK antibody, IKK-beta antibody, IKKb antibody, IKKbeta antibody, IRD-5 antibody, IRD5 antibody, Ik antibody, Ikkb antibody, Ikkbeta antibody, Ird-5 antibody, Ird5 antibody, LRK antibody, Lak antibody, anon-89Bd antibody, dIKK antibody, dIKK-beta antibody, dIKKbeta antibody, dLak antibody, dmIKKbeta antibody, ikk antibody, ird antibody, ird5/DmIkk[beta] antibody, IKK2 antibody, NFKBIKB antibody, AIM-1 antibody, AI132552 antibody, IKK-2 antibody, IKK[b] antibody, inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta L homeolog antibody, inhibitor of nuclear factor kappa B kinase subunit beta antibody, I-kappaB kinase beta antibody, inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta antibody, inhibitor of kappaB kinase beta antibody, ikbkb.L antibody, IKBKB antibody, ikbkb antibody, IKKbeta antibody, Ikbkb antibody

背景

NFKB1 (MIM 164011) or NFKB2 (MIM 164012) is bound to REL (MIM 164910), RELA (MIM 164014), or RELB (MIM 604758) to form the NFKB complex. The NFKB complex is inhibited by I-kappa-B proteins (NFKBIA, MIM 164008, or NFKBIB, MIM 604495), which inactivate NF-kappa-B by trapping it in the cytoplasm. Phosphorylation of serine residues on the I-kappa-B proteins by kinases (IKBKA, MIM 600664, or IKBKB) marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF-kappa-B complex. Activated NFKB complex translocates into the nucleus and binds DNA at kappa-B-binding motifs such as 5-prime GGGRNNYYCC 3-prime or 5-prime HGGARNYYCC 3-prime (where H is A, C, or T, R is an A or G purine, and Y is a C or T pyrimidine).

分子量

86564

NCBI登录号

NP_001177649, NP_001229707, NP_001547

UniProt

O14920

途径

NF-kappaB Signaling, RTK signaling, TCR Signaling, TLR signaling, Fc-epsilon Receptor Signaling Pathway, Neurotrophin Signaling Pathway, Activation of Innate immune Response, Production of Molecular Mediator of Immune Response, Hepatitis C, Toll-Like Receptors Cascades, BCR Signaling, Ubiquitin Proteasome Pathway, S100 Proteins