IKBKB 抗体 (pTyr199)
(1 reference)-
- 抗原 See all IKBKB 抗体
- IKBKB (Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase beta (IKBKB))
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抗原表位
- pTyr199
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适用
- 人, 小鼠, 大鼠, 猴
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This IKBKB antibody is un-conjugated
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应用范围
- ELISA, Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)
- 特异性
- Phospho-IKK- beta (Tyr199) Antibody detects endogenous levels of IKK- beta only when phosphorylated at Tyrosine 199
- 交叉反应
- 人, 猴, 小鼠, 大鼠
- 纯化方法
- The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns.
- 免疫原
- A synthesized peptide derived from human IKK- beta around the phosphorylation site of Tyrosine 199
- 亚型
- IgG
- Top Product
- Discover our top product IKBKB Primary Antibody
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anti-Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase beta (IKBKB) (AA 630-730) antibody
IKBKB 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase beta (IKBKB) (C-Term) antibodyIKBKB 适用: 人 WB, IF, IHC (p), ICC 宿主: 兔 Polyclonal unconjugated
anti-Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase beta (IKBKB) antibodyIKBKB 适用: 人, 小鼠, 大鼠 IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase beta (IKBKB) (AA 3-120) antibodyIKBKB 适用: 人 ELISA, WB, PLA 宿主: 小鼠 Monoclonal 1A3 unconjugated
anti-Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase beta (IKBKB) antibodyIKBKB 适用: 人 WB, IHC, IF 宿主: 兔 Monoclonal unconjugated
anti-Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase beta (IKBKB) antibodyIKBKB 适用: 人 ELISA, WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase beta (IKBKB) (AA 395-588) antibodyIKBKB 适用: 人 ELISA, WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase beta (IKBKB) antibodyIKBKB 适用: 人 ELISA, WB, IHC, IF 宿主: 兔 Monoclonal 3E1 unconjugated Recombinant Antibody
anti-Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase beta (IKBKB) (AA 3-120) antibodyIKBKB 适用: 人 ELISA, WB, IF 宿主: 小鼠 Monoclonal 3C12 unconjugated
anti-Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase beta (IKBKB) (pTyr188) antibodyIKBKB 适用: 人, 小鼠, 大鼠, 猴 ELISA, WB, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- WB 1:500-1:2000 IHC 1:50-1:200, IF/ICC 1:100-1:500
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 mg/mL
- 缓冲液
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store at -20 °C.Stable for 12 months from date of receipt
- 有效期
- 12 months
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: "Nuclear Localization Leucine-Rich-Repeat Protein 1 Deficiency Protects Against Cardiac Hypertrophy by Pressure Overload." in: Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, Vol. 48, Issue 1, pp. 75-86, (2018) (PubMed).
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: "Nuclear Localization Leucine-Rich-Repeat Protein 1 Deficiency Protects Against Cardiac Hypertrophy by Pressure Overload." in: Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, Vol. 48, Issue 1, pp. 75-86, (2018) (PubMed).
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- 抗原
- IKBKB (Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase beta (IKBKB))
- 别名
- IKK beta (IKBKB 产品)
- 别名
- ikk-beta antibody, ikk2 antibody, ikkb antibody, ikkbeta antibody, IKBKB antibody, IKKB antibody, CG4201 antibody, DIK antibody, DLAK antibody, DmIKK antibody, DmIKKBeta antibody, DmIKKb antibody, DmIKKbeta antibody, DmIkkbeta antibody, Dmel\\CG4201 antibody, Dmikkb antibody, Dmikkbeta antibody, IK antibody, IKK antibody, IKK-beta antibody, IKKb antibody, IKKbeta antibody, IRD-5 antibody, IRD5 antibody, Ik antibody, Ikkb antibody, Ikkbeta antibody, Ird-5 antibody, Ird5 antibody, LRK antibody, Lak antibody, anon-89Bd antibody, dIKK antibody, dIKK-beta antibody, dIKKbeta antibody, dLak antibody, dmIKKbeta antibody, ikk antibody, ird antibody, ird5/DmIkk[beta] antibody, IKK2 antibody, NFKBIKB antibody, AIM-1 antibody, AI132552 antibody, IKK-2 antibody, IKK[b] antibody, inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta L homeolog antibody, inhibitor of nuclear factor kappa B kinase subunit beta antibody, I-kappaB kinase beta antibody, inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta antibody, inhibitor of kappaB kinase beta antibody, ikbkb.L antibody, IKBKB antibody, ikbkb antibody, IKKbeta antibody, Ikbkb antibody
- 背景
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Description: Serine kinase that plays an essential role in the NF-kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses. Acts as part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B on 2 critical serine residues. These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome. In turn, free NF-kappa-B is translocated into the nucleus and activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis. In addition to the NF-kappa-B inhibitors, phosphorylates several other components of the signaling pathway including NEMO/IKBKG, NF-kappa-B subunits RELA and NFKB1, as well as IKK-related kinases TBK1 and IKBKE. IKK-related kinase phosphorylations may prevent the overproduction of inflammatory mediators since they exert a negative regulation on canonical IKKs. Phosphorylates FOXO3, mediating the TNF-dependent inactivation of this pro-apoptotic transcription factor. Also phosphorylates other substrates including NCOA3, BCL10 and IRS1. Within the nucleus, acts as an adapter protein for NFKBIA degradation in UV-induced NF-kappa-B activation.
Gene: IKBKB
- 分子量
- 85kDa
- 基因ID
- 3551
- UniProt
- O14920
- 途径
- NF-kappaB Signaling, RTK signaling, TCR Signaling, TLR signaling, Fc-epsilon Receptor Signaling Pathway, Neurotrophin Signaling Pathway, Activation of Innate immune Response, Production of Molecular Mediator of Immune Response, Hepatitis C, Toll-Like Receptors Cascades, BCR Signaling, Ubiquitin Proteasome Pathway, S100 Proteins
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