(1 reference)-
- 抗原 See all NR3C2 抗体
- NR3C2 (Nuclear Receptor Subfamily 3, Group C, Member 2 (NR3C2))
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抗原表位
- AA 966-984, C-Term
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This NR3C2 antibody is un-conjugated
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应用范围
- Western Blotting (WB)
- 原理
- Rabbit IgG polyclonal antibody for Mineralocorticoid receptor(NR3C2) detection. Tested with WB in Human,Mouse,Rat.
- 序列
- DQLPKVESGN AKPLYFHRK
- 交叉反应 （详细）
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Predicted Cross Reactivity: mouse, rat
No cross reactivity with other proteins.
Predicted Cross Reactivity: Species predicted to be fit for the product based on sequence similarities. - 产品特性
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Rabbit IgG polyclonal antibody for Mineralocorticoid receptor(NR3C2) detection. Tested with WB in Human,Mouse,Rat.
Gene Name: nuclear receptor subfamily 3, group C, member 2
Protein Name: Mineralocorticoid receptor(MR) - 纯化方法
- Immunogen affinity purified.
- 免疫原
- A synthetic peptide corresponding to a sequence at the C-terminus of human NR3C2(966-984aa DQLPKVESGNAKPLYFHRK), identical to the related mouse and rat sequences.
- 亚型
- IgG
- Top Product
- Discover our top product NR3C2 Primary Antibody
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anti-Nuclear Receptor Subfamily 3, Group C, Member 2 (NR3C2) (C-Term) antibody
NR3C2 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Nuclear Receptor Subfamily 3, Group C, Member 2 (NR3C2) antibodyNR3C2 适用: 人, 大鼠, 兔, 小鸡 WB, IHC, IHC (p) 宿主: 小鼠 Monoclonal H10E4C9F unconjugated
anti-Nuclear Receptor Subfamily 3, Group C, Member 2 (NR3C2) (AA 601-700) antibodyNR3C2 适用: 人, 大鼠, 小鼠, 犬 WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro), FACS 宿主: 兔 Polyclonal unconjugated
anti-Nuclear Receptor Subfamily 3, Group C, Member 2 (NR3C2) (AA 739-984) antibodyNR3C2 适用: 人 WB, ELISA, IHC (p), IHC (fro), ICC 宿主: 兔 Polyclonal unconjugated
anti-Nuclear Receptor Subfamily 3, Group C, Member 2 (NR3C2) antibodyNR3C2 适用: 人, 大鼠, 小鼠 IHC 宿主: 兔 Polyclonal unconjugated
anti-Nuclear Receptor Subfamily 3, Group C, Member 2 (NR3C2) antibodyMicroarray verified NR3C2 适用: 人, 小鼠 IHC 宿主: 小鼠 Monoclonal MAB719560 unconjugated
anti-Nuclear Receptor Subfamily 3, Group C, Member 2 (NR3C2) antibodyMicroarray verified NR3C2 适用: 人, 小鼠 IHC 宿主: 小鼠 Monoclonal MAB252256 unconjugated
anti-Nuclear Receptor Subfamily 3, Group C, Member 2 (NR3C2) (AA 1-110) antibodyNR3C2 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 2B5 unconjugated
anti-Nuclear Receptor Subfamily 3, Group C, Member 2 (NR3C2) (AA 651-700) antibodyNR3C2 适用: 人, 马, Cow, 猴 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Nuclear Receptor Subfamily 3, Group C, Member 2 (NR3C2) (AA 950-984), (C-Term) antibodyNR3C2 适用: 人, 大鼠, 小鼠 WB 宿主: 兔 Polyclonal unconjugated
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- 应用备注
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WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human, Predicted Species: Mouse, Rat
Notes: Tested Species: Species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities.
Other applications have not been tested. Optimal dilutions should be determined by end users. - 说明
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Antibody can be supported by chemiluminescence kit ABIN921124 in WB.
- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
- 浓度
- 500 μg/mL
- 缓冲液
- Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.
- 储存液
- Thimerosal (Merthiolate), Sodium azide
- 注意事项
- This product contains Sodium azide and Thimerosal (Merthiolate): POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.
- 注意事项
- Avoid repeated freezing and thawing.
- 储存条件
- 4 °C/-20 °C
- 储存方法
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At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing. - 有效期
- 12 months
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: "GPER is involved in the stimulatory effects of aldosterone in breast cancer cells and breast tumor-derived endothelial cells." in: Oncotarget, Vol. 7, Issue 1, pp. 94-111, (2016) (PubMed).
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: "GPER is involved in the stimulatory effects of aldosterone in breast cancer cells and breast tumor-derived endothelial cells." in: Oncotarget, Vol. 7, Issue 1, pp. 94-111, (2016) (PubMed).
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- 抗原
- NR3C2 (Nuclear Receptor Subfamily 3, Group C, Member 2 (NR3C2))
- 别名
- NR3C2 (NR3C2 产品)
- 别名
- mr antibody, si:ch211-189l17.1 antibody, LOC100302443 antibody, NR3C2 antibody, LOC443144 antibody, MLR antibody, MR antibody, MCR antibody, NR3C2VIT antibody, Mlr antibody, mlr antibody, nuclear receptor subfamily 3, group C, member 2 antibody, nuclear receptor subfamily 3 group C member 2 antibody, mineralocorticoid receptor antibody, nuclear receptor subfamily 3 group C member 2 L homeolog antibody, nr3c2 antibody, NR3C2 antibody, LOC443144 antibody, Nr3c2 antibody, nr3c2.L antibody
- 背景
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NR3C2 (nuclear receptor subfamily 3, group C, member 2), also known as MR (mineralocorticoid receptor), is a protein that in humans is encoded by the NR3C2 gene that is located on chromosome 4q31.1-31.2. It belongs to the nuclear receptor family where the ligand diffuses into cells, interacts with the receptor and results in a signal transduction affecting specific gene expression in the nucleus. This gene encodes the mineralocorticoid receptor, which mediates aldosterone actions on salt and water balance within restricted target cells. The protein functions as a ligand-dependent transcription factor that binds to mineralocorticoid response elements in order to transactivate target genes. Mutations in this gene cause autosomal dominant pseudohypoaldosteronism type I, a disorder characterized by urinary salt wasting. Defects in this gene are also associated with early onset hypertension with severe exacerbation in pregnancy. Alternative splicing results in multiple transcript variants.
Synonyms: Aldosterone receptor antibody|MCR antibody|MCR_HUMAN antibody|MGC133092 antibody|Mineralocorticoid receptor antibody|MLR antibody|MR antibody|NR3 C2 antibody|NR3C2 antibody|NR3C2 protein antibody|Nuclear receptor subfamily 3 group C member 2 antibody - UniProt
- P08235
- 途径
- ACE Inhibitor Pathway, Nuclear Receptor Transcription Pathway, Intracellular Steroid Hormone Receptor Signaling Pathway, Steroid Hormone Mediated Signaling Pathway
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