HLA-DRB5 抗体 (Center)
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- 抗原 See all HLA-DRB5 抗体
- HLA-DRB5 (Major Histocompatibility Complex, Class II, DR beta 5 (HLA-DRB5))
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抗原表位
- AA 43-70, Center
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This HLA-DRB5 antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunohistochemistry (IHC)
- 原理
- Rabbit Anti-Human HLA-DRB5 (Center) Antibody
- 免疫原
- This HLA-DRB5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 43-70 amino acids from the Central region of human HLA-DRB5.
- 亚型
- Ig Fraction
- Top Product
- Discover our top product HLA-DRB5 Primary Antibody
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- 应用备注
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Western Blot, Immunohistochemistry
Recommended Dilutions
WB: 1:1000, IHC: 1:50-100Western blot analysis of HLA-DRB5 Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated. - 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 0.5 mg/mL
- 储存条件
- 4 °C,-20 °C
- 储存方法
- 2-8°C (short-term), -20°C (long-term)
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- 抗原
- HLA-DRB5 (Major Histocompatibility Complex, Class II, DR beta 5 (HLA-DRB5))
- 别名
- HLA-DRB5 (HLA-DRB5 产品)
- 别名
- HLA-DRB antibody, major histocompatibility complex, class II, DR beta 5 antibody, HLA-DRB5 antibody
- 背景
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Target Description: HLA-DRB5 belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DRA) and a beta (DRB) chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. DRB1 is expressed at a level five times higher than its paralogues DRB3, DRB4 and DRB5. The presence of DRB5 is linked with allelic variants of DRB1, otherwise it is omitted. There are 4 related pseudogenes: DRB2, DRB6, DRB7, DRB8 and DRB9.
Gene Symbol: HLA-DRB5
- 分子量
- 30056 Da
- 基因ID
- 3127
- UniProt
- Q30154
- 途径
- TCR Signaling, Positive Regulation of Peptide Hormone Secretion, Production of Molecular Mediator of Immune Response, Cancer Immune Checkpoints
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