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HLA-DRB5 产品

(Major Histocompatibility Complex, Class II, DR beta 5 (HLA-DRB5))

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HLA-DRB5 belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DRA) and a beta (DRB) chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. DRB1 is expressed at a level five times higher than its paralogues DRB3, DRB4 and DRB5. The presence of DRB5 is linked with allelic variants of DRB1, otherwise it is omitted. There are 4 related pseudogenes: DRB2, DRB6, DRB7, DRB8 and DRB9. [provided by RefSeq, Jul 2008].

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HLA-DRB5 抗体

High quality antibodies with extensive validation data.

HLA-DRB5 ELISA试剂盒

Reliable ELISA kits for a wide range of species.

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Cat. No. ABIN7246217
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Reactivity Human
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Cat. No. ABIN6968427
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Latest Publications for our HLA-DRB5 Products

Marcussen, Bødker, Christensen, Johansen, Nielsen, Christiansen, Bergmann, Bøgsted, Dybkær, Vyberg, Johnsen: "Molecular Characteristics of High-Dose Melphalan Associated Oral Mucositis in Patients with Multiple Myeloma: A Gene Expression Study on Human Mucosa." in: PLoS ONE, Vol. 12, Issue 1, pp. e0169286, (2017) (PubMed).

Synonyms and alternative names related to HLA-DRB5

major histocompatibility complex, class II, DR beta 5 (HLA-DRB5), HLA-DRB

Protein level used designations for HLA-DRB5

  • DR beta-5
  • DR-9
  • DR2-beta-2
  • DR9
  • HLA class II histocompatibility antigen, DR beta 5 chain
  • HLA class II histocompatibility antigen, DR-5 beta chain
  • HLA class II histocompatibility antigen, DRB1-9 beta chain
  • MHC HLA-DR-beta cell surface glycoprotein
  • MHC HLA-DR-beta chain
  • MHC class II HLA beta chain
  • MHC class II antigen DRB1*9
  • MHC class II antigen DRB5
  • dw2
  • human leucocyte antigen DRB5
  • leukocyte antigen class II
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