HLA-DRB5 抗体 (AA 43-70)
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- 抗原 See all HLA-DRB5 抗体
- HLA-DRB5 (Major Histocompatibility Complex, Class II, DR beta 5 (HLA-DRB5))
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抗原表位
- AA 43-70
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This HLA-DRB5 antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- 纯化方法
- This antibody is purified through a protein A column, followed by peptide affinity purification.
- 免疫原
- This HLA-DRB5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 43-70 amino acids from the Central region of human HLA-DRB5.
- 克隆位点
- RB22398
- 亚型
- Ig Fraction
- Top Product
- Discover our top product HLA-DRB5 Primary Antibody
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anti-Major Histocompatibility Complex, Class II, DR beta 5 (HLA-DRB5) (AA 1-266) antibody
HLA-DRB5 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-Major Histocompatibility Complex, Class II, DR beta 5 (HLA-DRB5) antibodyHLA-DRB5 适用: 人 IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Major Histocompatibility Complex, Class II, DR beta 5 (HLA-DRB5) (AA 1-266) antibodyHLA-DRB5 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Major Histocompatibility Complex, Class II, DR beta 5 (HLA-DRB5) (AA 49-79), (Middle Region) antibodyHLA-DRB5 适用: 人 WB, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- WB: 1:1000. IHC-P: 1:50~100
- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
- Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C,-20 °C
- 储存方法
- Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
- 有效期
- 6 months
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- 抗原
- HLA-DRB5 (Major Histocompatibility Complex, Class II, DR beta 5 (HLA-DRB5))
- 别名
- HLA-DRB5 (HLA-DRB5 产品)
- 别名
- HLA-DRB antibody, major histocompatibility complex, class II, DR beta 5 antibody, HLA-DRB5 antibody
- 背景
- HLA-DRB5 belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DRA) and a beta (DRB) chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. DRB1 is expressed at a level five times higher than its paralogues DRB3, DRB4 and DRB5. The presence of DRB5 is linked with allelic variants of DRB1, otherwise it is omitted. There are 4 related pseudogenes: DRB2, DRB6, DRB7, DRB8 and DRB9.
- 分子量
- 30056
- 基因ID
- 3127
- NCBI登录号
- NP_002116
- UniProt
- Q30154
- 途径
- TCR Signaling, Positive Regulation of Peptide Hormone Secretion, Production of Molecular Mediator of Immune Response, Cancer Immune Checkpoints
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