HLA-DRB5 抗体 (Middle Region)
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- 抗原 See all HLA-DRB5 抗体
- HLA-DRB5 (Major Histocompatibility Complex, Class II, DR beta 5 (HLA-DRB5))
- 抗原表位
- AA 49-79, Middle Region
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This HLA-DRB5 antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)
- 特异性
- This antibody recognizes Human HLA class II DRB5 beta / HLA-DRB5 (Center).
- 纯化方法
- Protein A column, followed by peptide affinity purification
- 免疫原
- KLH conjugated synthetic peptide between 49~79 amino acids from the Central region of human HLA class II DRB5 beta / HLA-DRB5
- 亚型
- Ig Fraction
- Top Product
- Discover our top product HLA-DRB5 Primary Antibody
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anti-Major Histocompatibility Complex, Class II, DR beta 5 (HLA-DRB5) (AA 1-266) antibody
HLA-DRB5 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-Major Histocompatibility Complex, Class II, DR beta 5 (HLA-DRB5) antibodyHLA-DRB5 适用: 人 IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Major Histocompatibility Complex, Class II, DR beta 5 (HLA-DRB5) (AA 1-266) antibodyHLA-DRB5 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Major Histocompatibility Complex, Class II, DR beta 5 (HLA-DRB5) (AA 43-70) antibodyHLA-DRB5 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB22398 unconjugated
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- 应用备注
- Optimal working dilution should be determined by the investigator.
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 0.25 mg/mL
- 缓冲液
- PBS containing 0.09 % (W/V) Sodium Azide as preservative
- 储存液
- Sodium azide
- 注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 注意事项
- Avoid repeated freezing and thawing.
- 储存条件
- 4 °C/-20 °C
- 储存方法
- Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
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- 抗原
- HLA-DRB5 (Major Histocompatibility Complex, Class II, DR beta 5 (HLA-DRB5))
- 别名
- HLA Class II DRB5 beta / HLA-DRB5 (HLA-DRB5 产品)
- 别名
- HLA-DRB antibody, major histocompatibility complex, class II, DR beta 5 antibody, HLA-DRB5 antibody
- 背景
- HLA-DRB5 belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DRA) and a beta (DRB) chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. DRB1 is expressed at a level five times higher than its paralogues DRB3, DRB4 and DRB5. The presence of DRB5 is linked with allelic variants of DRB1, otherwise it is omitted. There are 4 related pseudogenes: DRB2, DRB6, DRB7, DRB8 and DRB9.Synonyms: DR beta-5, DR2-beta-2, DRB5 beta chain, Dw2, HLA class II histocompatibility antigen, MHC class II antigen DRB5
- 分子量
- 30056 Da
- 基因ID
- 3127
- NCBI登录号
- NP_002116
- 途径
- TCR Signaling, Positive Regulation of Peptide Hormone Secretion, Production of Molecular Mediator of Immune Response, Cancer Immune Checkpoints
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