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C-JUN 抗体 (pThr239)

This anti-C-JUN antibody is a 兔 多克隆 antibody detecting C-JUN in WB, IF 和 IHC (p). Suitable for 人 和 小鼠.
产品编号 ABIN196652
发货至: 中国
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Room 801-803
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Quick Overview for C-JUN 抗体 (pThr239) (ABIN196652)

抗原

See all C-JUN (JUN) 抗体
C-JUN (JUN) (Jun Proto-Oncogene (JUN))

适用

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宿主

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克隆类型

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多克隆

标记

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This C-JUN antibody is un-conjugated

应用范围

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Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
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    pThr239

    特异性

    C-Jun (phospho-Thr239) antibody detects endogenous levels of c-Jun only when phosphorylated at threonine 239.

    纯化方法

    Immunoaffinity chromatography

    免疫原

    Synthetic phosphopeptide derived from human c-Jun around the phosphorylation site of threonine 239 (G-E-TP-P-P).
  • 应用备注

    Suitable for use in Western blot (1: 500approx. 1: 1000) and Immunohistochemistry (1: 50approx. 1: 100).
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.

    限制

    仅限研究用
  • 浓度

    1.0 mg/mL

    缓冲液

    Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl containing 0.02 % Sodium Azide as preservative and 50 % glycerol as stabilizer

    储存液

    Sodium azide

    注意事项

    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    注意事项

    Avoid repeated freezing and thawing.

    储存条件

    -20 °C

    储存方法

    Store the antibody (in aliquots) at -20 °C.
  • 抗原

    C-JUN (JUN) (Jun Proto-Oncogene (JUN))

    别名

    AP-1 / C-Jun

    背景

    The human protooncogene JUN is the putative transforming gene of avian sarcoma virus 17, and it encodes a protein which is highly homologous to the viral protein. cJun (previously known as the Fos binding protein p39) and c Fos form a complex in the nucleus. AP 1 (activating protein 1) is a collective term referring to these dimeric transcription factors composed of Jun, Fos or ATF subunits that bind to a common DNA site, the AP1 binding site. AP 1 proteins, mostly the Jun group, regulate the expression and function of cell cycle regulators such as Cyclin D1, p53, p21 (cip1/waf1), p19 (ARF) and p16. Fos and Jun proto oncogene expression is induced transiently by a variety of extracellular stimuli associated with mitogenesis, differentiation processes or depolarization of neurons. JUN has been mapped to 1p32 to p31, a chromosomal region involved in both translocations and deletions in human malignancies.Synonyms: Activator protein 1, Proto-oncogene c-jun, Transcription factor AP1, V-jun avian sarcoma virus 17 oncogene homolog, p39

    基因ID

    3725

    NCBI登录号

    NP_002219

    UniProt

    P05412

    途径

    MAPK Pathway, RTK signaling, WNT signaling, Fc-epsilon Receptor Signaling Pathway, Activation of Innate immune Response, Myometrial Relaxation and Contraction, Skeletal Muscle Fiber Development, Protein targeting to Nucleus, Toll-Like Receptors Cascades, Autophagy, Signaling of Hepatocyte Growth Factor Receptor, BCR Signaling, S100 Proteins
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