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WNT signaling

Wnts are a class of evolutionarily-conserved, lipid-modified glycoproteins that play a pivotal role in development and homeostasis through a number of different paracrine and autocrine signal-transduction pathways. During early development, Wnt signaling plays a major role in axon guidance, cell polarity, and body axis specification.

Extracellular Wnts bind a variety of different receptors, and initiate signaling in several distinct pathways. Receptors include seven-pass transmembrane Frizzleds and receptor tyrosine kinases ROR and Ryk.

Wnt signaling pathways can result in changes to gene transcription. For example, in the canonical β-catenin signaling pathway Wnt signaling prevents destruction of the transcriptional regulator β-catenin. Wnt signaling can also prompt morphological changes to cellular structure e.g., the non-canonical planar cell polarity pathway induces a kinase cascade that results in reorganization of actin, a core component of the cytoskeleton.

Antagonists

ZNRF3 (Zinc and Ring Finger Protein 3):

beta-Catenin Pathway

TCF7L1 (Transcription Factor 7-Like 1 (T-Cell Specific, HMG-Box)):

TCF7L2 (Transcription Factor 7-Like 2 (T-Cell Specific, HMG-Box)):

LLGL1 (Lethal Giant Larvae Homolog 1 (Drosophila)):

LLGL2 (Lethal Giant Larvae Homolog 2 (Drosophila)):

PYGO1 (Pygopus Homolog 1 (Drosophila)):

PYGO2 (Pygopus Homolog 2 (Drosophila)):

TCF3 (Transcription Factor 3 (E2A Immunoglobulin Enhancer Binding Factors E12/E47)):

TCF7 (Transcription Factor 7 (T-Cell Specific, HMG-Box)):

TLE1 (Transducin-Like Enhancer of Split 1 (E(sp1) Homolog, Drosophila)):

TLE2 (Transducin-Like Enhancer of Split 2 (E(sp1) Homolog, Drosophila)):

TLE4 (Transducin-Like Enhancer of Split 4 (E(sp1) Homolog, Drosophila)):

TLE6 (Transducin-Like Enhancer of Split 6 (E(sp1) Homolog, Drosophila)):

Calcium Pathway

PPP3CA (Protein Phosphatase 3, Catalytic Subunit, alpha Isoform):

PLCB3 (phospholipase C, beta 3 (Phosphatidylinositol-Specific)):

PPP3CB (Protein Phosphatase 3, Catalytic Subunit, beta Isozyme):

PPP3CC (Protein Phosphatase 3, Catalytic Subunit, gamma Isozyme):

Co-Receptors

Frizzleds

PCP Pathway

MAPK10 (Mitogen-Activated Protein Kinase 10):

NFAT5 (Nuclear Factor of Activated T-Cells 5, Tonicity-Responsive):

NFATC1 (Nuclear Factor of Activated T-Cells, Cytoplasmic, Calcineurin-Dependent 1):

NFAT1 (Nuclear Factor of Activated T-Cells, Cytoplasmic, Calcineurin-Dependent 2):

NFATC3 (Nuclear Factor of Activated T-Cells, Cytoplasmic, Calcineurin-Dependent 3):

NFATC4 (Nuclear Factor of Activated T-Cells, Cytoplasmic, Calcineurin-Dependent 4):

ROCK1 (rho-Associated, Coiled-Coil Containing Protein Kinase 1):

ROCK2 (rho-Associated, Coiled-Coil Containing Protein Kinase 2):

Receptor Tyrosine Kinases

WNTs

WNT8B (Wingless-Type MMTV Integration Site Family, Member 8B):

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