C-JUN 抗体 (pSer73)
Our Local Distributor
北京 101111
Quick Overview for C-JUN 抗体 (pSer73) (ABIN127167)
抗原
See all C-JUN (JUN) 抗体适用
宿主
克隆类型
标记
应用范围
-
-
抗原表位
- pSer73
-
特异性
- The Phospho-c-Jun (Ser73) antibody detects only activated c-Jun when phosphorylated at Ser73. It does not react with non-phosphorylated c-Jun.
-
纯化方法
- Affinity purified
-
-
-
-
应用备注
-
Western Blot: 1 μg/mL. Immunohistochemistry: 20 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
-
-
-
浓度
- 0.5 mg/mL
-
缓冲液
- PBS, pH 7.2, containing 50 % glycerol, 1 % BSA, 0.02 % thimerosal
-
储存液
- Thimerosal (Merthiolate)
-
注意事项
- This product contains thimerosal (merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
注意事项
- Avoid repeated freezing and thawing.
-
储存条件
- -20 °C/-80 °C
-
储存方法
- Store the antibody undiluted at -20 °C or for long term storage (in aliquots) at -70 °C.
-
-
- C-JUN (JUN) (Jun Proto-Oncogene (JUN))
-
别名
- AP-1 / C-Jun
-
背景
- C-Jun is a component of the transcription factor AP-1 that binds and activates transcription at TRE/AP-1 elements. The transcriptional activity of c-Jun is regulated by phosphorylation at Ser63 and Ser73. Extracellular signals, such as growth factors and UV irradiation, stimulate phosphorylation of c-Jun at Ser63/73 and activate c-Jun dependent transcription. The MAP kinase homologue, SAPK/JNK, binds to the N-terminal region of c-Jun and phosphorylates c- Jun at Ser63/73.Synonyms: Activator protein 1, Proto-oncogene c-jun, Transcription factor AP1, V-jun avian sarcoma virus 17 oncogene homolog, p39
-
基因ID
- 3725
-
NCBI登录号
- NP_002219
-
UniProt
- P05412
-
途径
- MAPK Pathway, RTK signaling, WNT signaling, Fc-epsilon Receptor Signaling Pathway, Activation of Innate immune Response, Myometrial Relaxation and Contraction, Skeletal Muscle Fiber Development, Protein targeting to Nucleus, Toll-Like Receptors Cascades, Autophagy, Signaling of Hepatocyte Growth Factor Receptor, BCR Signaling, S100 Proteins
抗原
-