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IKBKG 抗体 (pSer376) (PE)

Name: IKBKG 抗体 (pSer376) (PE)
SKU: ABIN1177069
Availability: OutOfStock

IKBKG 适用: 人 ICS 宿主: 小鼠 Monoclonal N19-39 PE

(6 references)

产品编号 ABIN1177069

发货至: 中国

Datasheet as PDF

抗原 See all IKBKG 抗体

IKBKG (Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase gamma (IKBKG))
抗原表位
28

16

13

12

5

3

3

3

3

2

2

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
pSer376
适用
134

48

42

6

4

4

4

4

3

2

1
人
宿主
120

17

2
小鼠
Compatible Secondaries
克隆类型
115

24
单克隆
标记
75

8

6

6

6

6

6

6

4

3

2

2

2

2

2

2

1
This IKBKG antibody is conjugated to PE
应用范围
86

50

28

27

25

24

20

17

10

8

5

2

1

1

1
Intracellular Staining (ICS)

品牌

BD Phosflow™

纯化方法

The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

免疫原

Phosphorylated Human IKKgamma Peptide

克隆位点

N19-39

亚型

IgG1 kappa

Top Product

Discover our top product IKBKG Primary Antibody
anti-Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase gamma (IKBKG) (AA 1-419) antibody
IKBKG 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated

anti-Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase gamma (IKBKG) (AA 1-419) antibody
IKBKG 适用: 人 WB, ELISA, IF, IHC (p), PLA 宿主: 小鼠 Monoclonal 4G9 unconjugated

anti-Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase gamma (IKBKG) (AA 60-120) antibody
IKBKG 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated

anti-Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase gamma (IKBKG) (AA 1-110) antibody
IKBKG 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 1D4 unconjugated

anti-Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase gamma (IKBKG) (N-Term) antibody
IKBKG 适用: 人, 小鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated

anti-Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase gamma (IKBKG) (pSer31) antibody
IKBKG 适用: 人 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated

anti-Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase gamma (IKBKG) (pSer85) antibody
IKBKG 适用: 人, 小鼠 WB, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated

anti-Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase gamma (IKBKG) (AA 1-419) antibody
IKBKG 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated

anti-Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase gamma (IKBKG) (Ser85) antibody
IKBKG 适用: 人 WB, ELISA, IF 宿主: 兔 Polyclonal unconjugated

anti-Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase gamma (IKBKG) antibody
IKBKG 适用: 大鼠 IHC 宿主: 兔 Polyclonal unconjugated

样本量

5 μL

限制

仅限研究用
状态

Liquid

缓冲液

Aqueous buffered solution containing BSA and ≤0.09 % sodium azide.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

4 °C

储存方法

Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze. The antibody was conjugated with R-PE under optimum conditions, and unconjugated antibody and free PE were removed.
Shifera: "The zinc finger domain of IKKγ (NEMO) protein in health and disease." in: Journal of cellular and molecular medicine, Vol. 14, Issue 10, pp. 2404-14, (2010) (PubMed).

Carter, Pennington, Ungurait, Ballard: "In vivo identification of inducible phosphoacceptors in the IKKgamma/NEMO subunit of human IkappaB kinase." in: The Journal of biological chemistry, Vol. 278, Issue 22, pp. 19642-8, (2003) (PubMed).

Ling, Cao, Goeddel: "NF-kappaB-inducing kinase activates IKK-alpha by phosphorylation of Ser-176." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 95, Issue 7, pp. 3792-7, (1998) (PubMed).

Rothwarf, Zandi, Natoli, Karin: "IKK-gamma is an essential regulatory subunit of the IkappaB kinase complex." in: Nature, Vol. 395, Issue 6699, pp. 297-300, (1998) (PubMed).

DiDonato, Hayakawa, Rothwarf, Zandi, Karin: "A cytokine-responsive IkappaB kinase that activates the transcription factor NF-kappaB." in: Nature, Vol. 388, Issue 6642, pp. 548-54, (1997) (PubMed).

Mercurio, Zhu, Murray, Shevchenko, Bennett, Li, Young, Barbosa, Mann, Manning, Rao: "IKK-1 and IKK-2: cytokine-activated IkappaB kinases essential for NF-kappaB activation." in: Science (New York, N.Y.), Vol. 278, Issue 5339, pp. 860-6, (1997) (PubMed).
抗原

IKBKG (Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase gamma (IKBKG))

Abstract

IKBKG 产品

别名

AMCBX1 antibody, FIP-3 antibody, FIP3 antibody, Fip3p antibody, IKK-gamma antibody, IP antibody, IP1 antibody, IP2 antibody, IPD2 antibody, NEMO antibody, ZC2HC9 antibody, 1110037D23Rik antibody, AI848108 antibody, AI851264 antibody, AW124339 antibody, IKK[g] antibody, Nemo antibody, nemo antibody, fj33c07 antibody, wu:fj33c07 antibody, zgc:113492 antibody, MGC97885 antibody, IKBKG antibody, IKBKG_1 antibody, IKBKG_2 antibody, CG16910 antibody, DmIKK-gamma antibody, DmIKKgamma antibody, Dmel\\CG16910 antibody, Dmikkgamma antibody, IKK antibody, IKK[[gamma]] antibody, IKKg antibody, IKKgamma antibody, KEY antibody, Kenny antibody, Key antibody, dIKK antibody, dIKK-gamma antibody, dmIKKgamma antibody, inhibitor of nuclear factor kappa B kinase subunit gamma antibody, inhibitor of kappaB kinase gamma antibody, inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma antibody, inhibitor of nuclear factor kappa B kinase subunit gamma L homeolog antibody, kenny antibody, IKBKG antibody, Ikbkg antibody, ikbkg antibody, ikbkg.L antibody, IKBKG_1 antibody, key antibody

背景

The N19-39 monoclonal antibody specifically binds to the IKK-gamma protein phosphorylated at the Ser376 site, ie, IKKgamma (pS376). IKKgamma is also known an NEMO (NF-kappa-B essential modifier) and is encoded by the IKBKG (inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma) gene. The nuclear transcription factor kappa-B, NF-kappaB, is controlled by interaction with an inhibitory subunit, IkappaB, which restricts NF-kappaB to the cytoplasm. Following stimulation by various cytokines or other stimuli, IkappaB becomes degraded and NF-kappaB is released to the nucleus. The release of IkappaB from NF-kappaB is thought to be a critical point in the activation of NF-kappaB signal pathways. Activated NF-kappaB regulates genes involved in various pathways including inflammation, immunity, and cell survival signaling pathways. A group of proteins form an NF-kappaB regulatory complex, or signalsome. Two members of this complex are a pair of closely related serine/threonine kinases, IKKalpha and IKKbeta (also called IKK-1 and IKK-2), which phosphorylate critical residues of IkappaB, thus targeting it for subsequent degradation. The IKK complex contains similar amounts of IKKalpha, IKKbeta as well as two other polypeptides, which are differentially processed forms of a third subunit, IKKgamma. IKKalpha and IKKbeta become activated following phosphorylation by upstream kinases, including NF-kappaB-inducing kinase (NIK)4 and MEKK1. IKKbeta has been shown to phosphorylate IKKgamma at serine 376 in response to signaling through the TNF receptor or the Tax oncoprotein of human T-cell leukemia virus type 1. IKKgamma has an essential regulatory role in the IKK complex and is required for the activation of the NF-kappaB pathway in response to multiple cellular stimuli. IKKgamma isoforms migrate as a doublet of ~50-55 kDa upon Western blot analysis.
Synonyms: IKBKG, IKKgamma, IKKG, IKK-gamma, AMCBX1, FIP3, IKKAP1, IP1, IP2, IPD2, NEMO

途径

NF-kappaB Signaling, RTK signaling, TCR Signaling, TLR signaling, Fc-epsilon Receptor Signaling Pathway, Activation of Innate immune Response, M Phase, Production of Molecular Mediator of Immune Response, Hepatitis C, Protein targeting to Nucleus, Toll-Like Receptors Cascades, BCR Signaling, Ubiquitin Proteasome Pathway, S100 Proteins