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The protein encoded by PTK6 is a cytoplasmic nonreceptor protein kinase which may function as an intracellular signal transducer in epithelial tissues.
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Human Polyclonal PTK6 Primary Antibody for IF, WB - ABIN519483
Foudah, Sallam, Akl, El Sayed: Optimization, pharmacophore modeling and 3D-QSAR studies of sipholanes as breast cancer migration and proliferation inhibitors. in European journal of medicinal chemistry 2014
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Human Monoclonal PTK6 Primary Antibody for IHC (p), ELISA - ABIN519484
Akl, Ayoub, Mohyeldin, Busnena, Foudah, Liu, Sayed: Olive phenolics as c-Met inhibitors: (-)-Oleocanthal attenuates cell proliferation, invasiveness, and tumor growth in breast cancer models. in PLoS ONE 2014
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Human Monoclonal PTK6 Primary Antibody for ELISA - ABIN966923
Ottilie, Raulf, Barnekow, Hannig, Schartl: Multiple src-related kinase genes, srk1-4, in the fresh water sponge Spongilla lacustris. in Oncogene 1992
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Human Monoclonal PTK6 Primary Antibody for ELISA, WB - ABIN969373
Wilks: Two putative protein-tyrosine kinases identified by application of the polymerase chain reaction. in Proceedings of the National Academy of Sciences of the United States of America 1989
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Human Polyclonal PTK6 Primary Antibody for IF (p), IHC (p) - ABIN1713614
Akl, Foudah, Ebrahim, Meyer, El Sayed: The marine-derived sipholenol A-4-O-3',4'-dichlorobenzoate inhibits breast cancer growth and motility in vitro and in vivo through the suppression of Brk and FAK signaling. in Marine drugs 2014
Human Monoclonal PTK6 Primary Antibody for ELISA, WB - ABIN2869234
Liu, Zhang, Zhong, Li, Liu, Lin, Wu, Zeng: Low expression of PTK6/Brk predicts poor prognosis in patients with laryngeal squamous cell carcinoma. in Journal of translational medicine 2013
Human Polyclonal PTK6 Primary Antibody for IHC (p), WB - ABIN392105
Derry, Prins, Ray, Tyner: Altered localization and activity of the intracellular tyrosine kinase BRK/Sik in prostate tumor cells. in Oncogene 2003
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These results indicate that plasma-membrane-associated PTK6 phosphorylates Eps8 (显示 EPS8 抗体), which promotes cell proliferation, adhesion, and migration
Expression of PTK6 in established tumors may maintain the epithelial phenotype, preventing tumor progression.
analysis of recombinant PTK6 kinase domain by x-ray crystallography reveals details of its binding to inhibitors
The crystal structure of the kinase domain of human PTK6 has been reported.
PTK6 mRNA and protein levels were elevated in cervical squamous cell cancer and the elevated cytoplasmic expression of PTK6 was associated with tumor grade and short patient survival.
PELP1 (显示 PELP1 抗体) interacted with GR to activate Brk expression.
PTK6 prolongs S-phase and increases the ability of gemcitabine to cause DNA damage in vitro and in vivo
BRK expression in a majority of CC can interact with RTK, augmenting growth and interfering with proliferation inhibitors (SAM68 (显示 KHDRBS1 抗体)). Therapeutically targeting BRK function (in addition to RTK) should be of benefit for CC treatment.
Additive impact of HER2 (显示 ERBB2 抗体)-/PTK6-RNAi on interactions with HER3 (显示 ERBB3 抗体) or IGF-1R (显示 IGF1R 抗体) leads to reduced breast cancer progression
overexpression or knockdown of PTK6 or ERK1/2 effectively removed the inhibition of S1P-induced migration by miR-17.
PTK6 may act as a novel mediator of TNFalpha (显示 TNF 抗体)/IFNgamma intestinal epithelial permeability during inflammatory injury, and miR (显示 MLXIP 抗体)-93 may protect intestinal epithelial barrier function, at least in part, by targeting PTK6
Ptk6 promotes ERBB2 (显示 ERBB2 抗体)-induced mammary gland tumorigenesis in the mouse.
Protein tyrosine kinase 6 has a role in mediating TNFalpha (显示 TNF 抗体)-induced endothelial barrier dysfunction
Protein tyrosine kinase 6 protects cells from anoikis by directly phosphorylating focal adhesion kinase and activating AKT (显示 AKT1 抗体).
expression of Brk/PTK6 in non-transformed mammary epithelial cells mediates p38 MAPK (显示 MAPK14 抗体) phosphorylation and promotes increased cellular survival, delayed involution, and latent tumor formation.
a novel function for PTK6 at the plasma membrane
PTK6 promotes STAT3 (显示 STAT3 抗体) activation in the colon following injection of the carcinogen azoxymethane and regulates STAT3 (显示 STAT3 抗体) activity in mouse colon tumors.
AKT (显示 AKT1 抗体) is a direct substrate of PTK6 and AKT (显示 AKT1 抗体) tyrosine residues 315 and 326 are phosphorylated by PTK6.
PTK6 associates with nuclear and cytoplasmic beta-catenin (显示 CTNNB1 抗体) and inhibits beta-catenin (显示 CTNNB1 抗体)- and T-cell factor (TCF (显示 HNF4A 抗体))-mediated transcription.
The protein encoded by this gene is a cytoplasmic nonreceptor protein kinase which may function as an intracellular signal transducer in epithelial tissues. Overexpression of this gene in mammary epithelial cells leads to sensitization of the cells to epidermal growth factor and results in a partially transformed phenotype. Expression of this gene has been detected at low levels in some breast tumors but not in normal breast tissue. The encoded protein has been shown to undergo autophosphorylation. Alternative splicing results in multiple transcript variants.
PTK6 protein tyrosine kinase 6
, protein-tyrosine kinase 6-like
, breast tumor kinase
, protein-tyrosine kinase 6
, protein-tyrosine kinase BRK
, tyrosine-protein kinase BRK
, protein tyrosine kinase 6
, src-related intestinal kinase
, tyrosine kinase identified from skin