anti-PTK6 Protein tyrosine Kinase 6 (PTK6) 抗体

The protein encoded by PTK6 is a cytoplasmic nonreceptor protein kinase which may function as an intracellular signal transducer in epithelial tissues. 再加上,我们可以发PTK6 蛋白 (15)PTK6 试剂盒 (13)和数多这个蛋白质的别的产品。

列出全部抗体 基因 基因ID UniProt
PTK6 5753 Q13882
PTK6 20459 Q64434
PTK6 366275  
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antibodies-online.cn销售最多的anti-PTK6 抗体

Showing 10 out of 162 products:

产品编号 适用 宿主 标记 应用范围 图像 规格 供应商 交付 价格 详细
非结合性 WB <b>WB Suggested Anti-PTK6 Antibody Titration: </b>0.2-1 ug/ml<br><b>ELISA Titer: </b>1:1562500<br><b>Positive Control: </b>HepG2 cell lysate 100 μL Log in to see 2至3个工作日
$289.00
详细
非结合性 WB 100 μg Log in to see 2至3个工作日
$245.00
详细
非结合性 ELISA, WB Western blot analysis of extracts from LOVO cells, using Breast Tumor Kinase Antibody. The lane on the right is treated with the synthesized peptide. 100 μg Log in to see 2至3个工作日
$302.50
详细
非结合性 IF, ELISA, WB Western blot analysis of extracts from 293 cells treated with EGF 200ng/ml 30', using Breast Tumor Kinase (Phospho-Tyr447) Antibody. The lane on the right is treated with the synthesized peptide. Immunofluorescence analysis of NIH-3T3 cells, using Breast Tumor Kinase (Phospho-Tyr447) Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Log in to see 2至3个工作日
$302.50
详细
非结合性 ELISA, ICC, IF, IHC, WB ABIN6271435 staining 293 by IF/ICC. The sample were fixed with PFA and permeabilized in 0.1% Triton X-100,then blocked in 10% serum for 45 minutes at 25°C. The primary antibody was diluted at 1/200 and incubated with the sample for 1 hour at 37°C. An Alexa Fluor 594 conjugated goat anti-rabbit IgG (H+L) Ab, diluted at 1/600, was used as the secondary antibody. ABIN6271435 at 1/200 staining Mouse kidney tissue sections by IHC-P. The tissue was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The tissue was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary. 100 μL Log in to see 11至12个工作日
$450.00
详细
非结合性 IF, ELISA Immunofluorescence analysis of NIH-3T3 cells, using Breast Tumor Kinase (Ab-447) Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Log in to see 2至3个工作日
$302.50
详细
非结合性 IHC (p), WB Western blot analysis of anti-hPTK6-E26 Pab (ABIN392105) in A375 cell line lysate (35 µg/lane). hPTK6-E26(arrow) was detected using the purified polyclonal antibody (1:50 dilution). Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. BC = breast carcinoma. HC = hepatocarcinoma 400 μL Log in to see 10至11个工作日
$335.50
详细
小鼠 非结合性 ELISA, WB Figure 1: Western blot analysis using PTK6 mouse mAb against Hela (1), A549 (2) and MCF-7 (3) cell lysate. Dilution: 1/500 - 1/2000 Figure 2: Immunohistochemical analysis of paraffin-embedded maligant mesenchymoma tissues, showing cytoplasmic localization using C-kit mouse mAb with DAB staining. Dilution: 1:200~~1000 100 μL Log in to see 10至11个工作日
$561.00
详细
非结合性 ELISA, IF, WB 100 μL Log in to see 16 Days
$181.73
详细
非结合性 EIA, IHC (p), WB 0.4 mL Log in to see 6至8个工作日
$390.50
详细

引用最多的anti-PTK6 抗体

  1. Human Polyclonal PTK6 Primary Antibody for IF, WB - ABIN519483 : Foudah, Sallam, Akl, El Sayed: Optimization, pharmacophore modeling and 3D-QSAR studies of sipholanes as breast cancer migration and proliferation inhibitors. in European journal of medicinal chemistry 2014 (PubMed)
    Show all 3 Pubmed References

  2. Human Monoclonal PTK6 Primary Antibody for IHC (p), ELISA - ABIN519484 : Akl, Ayoub, Mohyeldin, Busnena, Foudah, Liu, Sayed: Olive phenolics as c-Met inhibitors: (-)-Oleocanthal attenuates cell proliferation, invasiveness, and tumor growth in breast cancer models. in PLoS ONE 2014 (PubMed)
    Show all 2 Pubmed References

  3. Human Polyclonal PTK6 Primary Antibody for IHC (p), WB - ABIN392105 : Derry, Prins, Ray, Tyner: Altered localization and activity of the intracellular tyrosine kinase BRK/Sik in prostate tumor cells. in Oncogene 2003 (PubMed)
    Show all 3 Pubmed References

  4. Human Monoclonal PTK6 Primary Antibody for ELISA - ABIN966923 : Ottilie, Raulf, Barnekow, Hannig, Schartl: Multiple src-related kinase genes, srk1-4, in the fresh water sponge Spongilla lacustris. in Oncogene 1992 (PubMed)
    Show all 3 Pubmed References

  5. Human Polyclonal PTK6 Primary Antibody for IF (p), IHC (p) - ABIN1713614 : Akl, Foudah, Ebrahim, Meyer, El Sayed: The marine-derived sipholenol A-4-O-3',4'-dichlorobenzoate inhibits breast cancer growth and motility in vitro and in vivo through the suppression of Brk and FAK signaling. in Marine drugs 2014 (PubMed)

  6. Human Monoclonal PTK6 Primary Antibody for ELISA, WB - ABIN969373 : Wilks: Two putative protein-tyrosine kinases identified by application of the polymerase chain reaction. in Proceedings of the National Academy of Sciences of the United States of America 1989 (PubMed)
    Show all 4 Pubmed References

  7. Human Monoclonal PTK6 Primary Antibody for ELISA, WB - ABIN2869234 : Liu, Zhang, Zhong, Li, Liu, Lin, Wu, Zeng: Low expression of PTK6/Brk predicts poor prognosis in patients with laryngeal squamous cell carcinoma. in Journal of translational medicine 2013 (PubMed)

更多抗PTK6的相互作用对抗体

Human PTK6 Protein tyrosine Kinase 6 (PTK6) interaction partners

  1. In prostate tumor tissue microarrays, loss of PTEN phosphohydrolase (PTEN) correlates with increased tyrosine kinase (显示 TXK 抗体) 6 PTK6 tyrosine 342 (PY342) phosphorylation and poor outcome.

  2. These results indicate that plasma-membrane-associated PTK6 phosphorylates Eps8 (显示 EPS8 抗体), which promotes cell proliferation, adhesion, and migration

  3. Expression of PTK6 in established tumors may maintain the epithelial phenotype, preventing tumor progression.

  4. analysis of recombinant PTK6 kinase domain by x-ray crystallography reveals details of its binding to inhibitors

  5. The crystal structure of the kinase domain of human PTK6 has been reported.

  6. PTK6 mRNA and protein levels were elevated in cervical squamous cell cancer and the elevated cytoplasmic expression of PTK6 was associated with tumor grade and short patient survival.

  7. PELP1 (显示 PELP1 抗体) interacted with GR to activate Brk expression.

  8. PTK6 prolongs S-phase and increases the ability of gemcitabine to cause DNA damage in vitro and in vivo

  9. BRK expression in a majority of CC can interact with RTK, augmenting growth and interfering with proliferation inhibitors (SAM68 (显示 KHDRBS1 抗体)). Therapeutically targeting BRK function (in addition to RTK) should be of benefit for CC treatment.

  10. Additive impact of HER2 (显示 ERBB2 抗体)-/PTK6-RNAi on interactions with HER3 (显示 ERBB3 抗体) or IGF-1R (显示 IGF1R 抗体) leads to reduced breast cancer progression

Mouse (Murine) PTK6 Protein tyrosine Kinase 6 (PTK6) interaction partners

  1. PTK6 may act as a novel mediator of TNFalpha (显示 TNF 抗体)/IFNgamma intestinal epithelial permeability during inflammatory injury, and miR (显示 MLXIP 抗体)-93 may protect intestinal epithelial barrier function, at least in part, by targeting PTK6

  2. PTK6 prolongs S-phase and increases the ability of gemcitabine to cause DNA damage in vitro and in vivo

  3. Ptk6 promotes ERBB2 (显示 ERBB2 抗体)-induced mammary gland tumorigenesis in the mouse.

  4. Protein tyrosine kinase 6 has a role in mediating TNFalpha (显示 TNF 抗体)-induced endothelial barrier dysfunction

  5. Protein tyrosine kinase 6 protects cells from anoikis by directly phosphorylating focal adhesion kinase and activating AKT (显示 AKT1 抗体).

  6. expression of Brk/PTK6 in non-transformed mammary epithelial cells mediates p38 MAPK (显示 MAPK14 抗体) phosphorylation and promotes increased cellular survival, delayed involution, and latent tumor formation.

  7. a novel function for PTK6 at the plasma membrane

  8. PTK6 promotes STAT3 (显示 STAT3 抗体) activation in the colon following injection of the carcinogen azoxymethane and regulates STAT3 (显示 STAT3 抗体) activity in mouse colon tumors.

  9. AKT (显示 AKT1 抗体) is a direct substrate of PTK6 and AKT (显示 AKT1 抗体) tyrosine residues 315 and 326 are phosphorylated by PTK6.

  10. PTK6 associates with nuclear and cytoplasmic beta-catenin (显示 CTNNB1 抗体) and inhibits beta-catenin (显示 CTNNB1 抗体)- and T-cell factor (TCF (显示 HNF4A 抗体))-mediated transcription.

PTK6 抗原简介

蛋白简介

The protein encoded by this gene is a cytoplasmic nonreceptor protein kinase which may function as an intracellular signal transducer in epithelial tissues. Overexpression of this gene in mammary epithelial cells leads to sensitization of the cells to epidermal growth factor and results in a partially transformed phenotype. Expression of this gene has been detected at low levels in some breast tumors but not in normal breast tissue. The encoded protein has been shown to undergo autophosphorylation. Alternative splicing results in multiple transcript variants.

Gene names and symbols associated with PTK6

  • protein tyrosine kinase 6 (PTK6) 抗体
  • PTK6 protein tyrosine kinase 6 (Ptk6) 抗体
  • protein tyrosine kinase 6 (Ptk6) 抗体
  • PTK6 protein tyrosine kinase 6b (ptk6b) 抗体
  • BRK 抗体
  • Sik 抗体
  • tks 抗体
  • Tksk 抗体
  • zgc:153964 抗体

Protein level used designations for PTK6

PTK6 protein tyrosine kinase 6 , breast tumor kinase , protein-tyrosine kinase 6 , protein-tyrosine kinase BRK , tyrosine-protein kinase BRK , protein tyrosine kinase 6 , src-related intestinal kinase , tyrosine kinase identified from skin , protein-tyrosine kinase 6-like

GENE ID SPECIES
5753 Homo sapiens
20459 Mus musculus
366275 Rattus norvegicus
529814 Bos taurus
100060532 Equus caballus
100438236 Pongo abelii
100589028 Nomascus leucogenys
767734 Danio rerio
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