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抗Human POLD4 抗体:
Human Monoclonal POLD4 Primary Antibody for ELISA, WB - ABIN528317
Zhang, Zhou, Trusa, Meng, Lee, Lee: A novel DNA damage response: rapid degradation of the p12 subunit of dna polymerase delta. in The Journal of biological chemistry 2007
Show all 3 Pubmed References
The identification of RNF8 allows new insights into the integration of the control of p12 degradation by different DNA damage signaling pathways.
the p12/Pol delta is a target as a nuclear substrate of mu-calpain in a calcium-triggered apoptosis and appears to be a potential marker in the study of the chemotherapy of cancer therapies.
A parallel study of Pol delta4 and Pol delta3 in Okazaki fragment processing provides evidence for a role of Pol delta3 in DNA replication
Findings provide evidence for the novel concept that Pol delta3 has a role in lagging strand synthesis, and that both forms of Pol delta3 and 4 may participate in DNA replication in higher eukaryotic cells.
ubiquitination of p12 through CRL4(Cdt2) and subsequent degradation form one mechanism by which a cell responds to DNA damage to inhibit fork progression.
Data indicate that CRL4(Cdt2) regulates the degradation of the p12 subunit of Pol delta4.
Low POLD4 is associated with lung cancer.
these results indicate that POLD4 is required for the in vitro pol delta activity, and that it functions in cell proliferation and maintenance of genomic stability of human cells.
pol delta interacts with PCNA via at least two of its subunits, and p12 could play a role in stabilizing the overall pol delta-PCNA complex as well as pol delta itself
The DNA polymerase delta enzyme, as well as the isolated p12 subunit, stimulates the DNA helicase activity of Bloom's syndrome helicase.
This gene encodes the smallest subunit of DNA polymerase delta. DNA polymerase delta possesses both polymerase and 3' to 5' exonuclease activity and plays a critical role in DNA replication and repair. The encoded protein enhances the activity of DNA polymerase delta and plays a role in fork repair and stabilization through interactions with the DNA helicase Bloom syndrome protein. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
DNA polymerase delta subunit 4
, DNA polymerase delta subunit p12
, DNA-directed DNA polymerase delta 4
, DNA polymerase delta smallest subunit p12