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- 抗原 See all POLD4 抗体
- POLD4 (Polymerase (DNA-Directed), delta 4, Accessory Subunit (POLD4))
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抗原表位
- Internal Region
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This POLD4 antibody is un-conjugated
- 应用范围
- Western Blotting (WB), ELISA, Immunohistochemistry (IHC)
- 特异性
- POLD4 Antibody detects endogenous levels of total POLD4.
- 预测反应
- Pig,Bovine,Horse,Sheep,Rabbit,Dog
- 纯化方法
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- 免疫原
- A synthesized peptide derived from human POLD4, corresponding to a region within the internal amino acids.
- 亚型
- IgG
- Top Product
- Discover our top product POLD4 Primary Antibody
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anti-Polymerase (DNA-Directed), delta 4, Accessory Subunit (POLD4) (AA 1-34) antibody
POLD4 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 2B11 unconjugated
anti-Polymerase (DNA-Directed), delta 4, Accessory Subunit (POLD4) (AA 1-34) antibodyPOLD4 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 2C11 unconjugated
anti-Polymerase (DNA-Directed), delta 4, Accessory Subunit (POLD4) antibodyPOLD4 适用: 人, 小鼠, 大鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-Polymerase (DNA-Directed), delta 4, Accessory Subunit (POLD4) antibodyPOLD4 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Polymerase (DNA-Directed), delta 4, Accessory Subunit (POLD4) (AA 1-107) antibodyPOLD4 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- WB 1:1000-3000, IHC 1:200, ELISA(peptide) 1:20000-1:40000
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 mg/mL
- 缓冲液
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store at -20 °C. Stable for 12 months from date of receipt.
- 有效期
- 12 months
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- 抗原
- POLD4 (Polymerase (DNA-Directed), delta 4, Accessory Subunit (POLD4))
- 别名
- POLD4 (POLD4 产品)
- 别名
- 2410012M21Rik antibody, AI463381 antibody, AW060307 antibody, Polds antibody, p12 antibody, POLDS antibody, DNA polymerase delta 4, accessory subunit antibody, polymerase (DNA-directed), delta 4 antibody, POLD4 antibody, Pold4 antibody
- 背景
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Description: As a component of the tetrameric DNA polymerase delta complex (Pol-delta4), plays a role in high fidelity genome replication and repair. Within this complex, increases the rate of DNA synthesis and decreases fidelity by regulating POLD1 polymerase and proofreading 3' to 5' exonuclease activity (PubMed:16510448, PubMed:19074196, PubMed:20334433). Pol-delta4 participates in Okazaki fragment processing, through both the short flap pathway, as well as a nick translation system (PubMed:24035200). Under conditions of DNA replication stress, required for the repair of broken replication forks through break-induced replication (BIR), a mechanism that may induce segmental genomic duplications of up to 200 kb (PubMed:24310611). Involved in Pol-delta4 translesion synthesis (TLS) of templates carrying O6-methylguanine or abasic sites (PubMed:19074196). Its degradation in response to DNA damage is required for the inhibition of fork progression and cell survival (PubMed:24022480).
Gene: POLD4
- 分子量
- 12 kDa
- 基因ID
- 57804
- UniProt
- Q9HCU8
- 途径
- Telomere Maintenance, DNA Damage Repair, DNA Replication, Synthesis of DNA
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