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抗Human H2AFZ 抗体:
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Human Polyclonal H2AFZ Primary Antibody for ChIPSeq, ChIP - ABIN4889649
El Gazzar, Liu, Yoza, McCall: Dynamic and selective nucleosome repositioning during endotoxin tolerance. in The Journal of biological chemistry 2010
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Human Polyclonal H2AFZ Primary Antibody for ChIPSeq, ChIP - ABIN2668307
Lodhi, Kossenkov, Tulin: Bookmarking promoters in mitotic chromatin: poly(ADP-ribose)polymerase-1 as an epigenetic mark. in Nucleic acids research 2014
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Mammalian Monoclonal H2AFZ Primary Antibody for - ABIN1304703
Satterlee, Beckel-Mitchener, McAllister, Procaccini, Rutter, Tyson, Chadwick: Community resources and technologies developed through the NIH Roadmap Epigenomics Program. in Methods in molecular biology (Clifton, N.J.) 2014
Two possible modes of pioneering associated with combinations of H2A.Z and p300/CBP (显示 CREBBP 抗体) at nucleosome-occupied enhancers.
Results indicate that accumulation of H2A.Z within repressed genes can also be a consequence of the repression of gene transcription rather than an active mechanism required to establish the repression.
Findings suggest the oncogenic potential of H2A.Z.1 in liver tumorigenesis and that it plays established role in accelerating cell cycle transition and EMT (显示 ITK 抗体) during hepatocarcinogenesis.
Crystal structure results show that the flexible character of the H2A.Z L1 loop plays an essential role in forming the stable heterotypic H2A.Z/H2A nucleosome.
Monoubiquitination of histone H2B blocks eviction of histone variant H2A.Z from inducible enhancers.
Thus, PWWP2A is a novel H2A.Z-specific multivalent chromatin binder providing a surprising link between H2A.Z, chromosome segregation, and organ development.
SMYD3 (显示 SMYD3 抗体)-mediated H2A.Z.1K101 dimethylation activates cyclin A1 (显示 CCNA1 抗体) expression and contributes to driving the proliferation of breast cancer cells.
Results suggest that the N-terminal tail of H2A.Z makes distinctively different contributions to epigenetic events.
the H2AFZ gene may confer a risk for schizophrenia and contribute to the impairment of executive function in Han Chinese patients with schizophrenia.
The 2.7-A-resolution crystal structure of the human YL1 (显示 VPS72 抗体)-H2A.Z-H2B complex shows that YL1 (显示 VPS72 抗体) binding, similarly to ANP32E (显示 ANP32E 抗体) binding, triggers an extension of the H2A.Z alphaC helix.
This study reveals an antagonistic relationship between H2A.Z.1ub and BRD2 (显示 BRD2 抗体) to regulate the transcriptional balance at bivalent genes to enable proper execution of developmental programs.
Embryonic stem cell BAF (显示 BANF1 抗体) is required for normal H2A.Z localization in these cells, suggesting BAF (显示 BANF1 抗体) either stabilizes H2A.Z containing nucleosomes or promotes subnucleosome to nucleosome conversion by facilitating H2A.Z deposition.
Study mapped H2A.Z genome-wide in embryonic stem cells and neural progenitors; H2A.Z is deposited at promoters and enhancers, and correlates strongly with H3K4 methylation. H2A.Z is present at poised promoters with bivalent chromatin and at active promoters with H3K4 methylation, but is absent from stably repressed promoters that are enriched for H3K27 trimethylation.
our work suggests that the divergent residues in the H2A.Z acidic patch comprise a unique domain that couples control of chromatin dynamics to the regulation of developmental gene expression patterns during lineage commitment.
Data propose that H2A.Z mediates such contrasting activities by acting as a general facilitator that generates access for a variety of complexes, both activating and repressive.
The variant histone H2A.Z and the winged helix transcription factor (显示 FOXC1 抗体) Foxa2 (显示 FOXA2 抗体) both act to regulate nucleosome depletion and gene activation, thus promoting embryonic stem cell differentiation, whereas DNA methylation (显示 HELLS 抗体) promotes nucleosome occupation and suppresses gene expression.
incorporation of the histone variant H2A.Z at the promoter regions of PPARgamma (显示 PPARG 抗体) target genes by p400 (显示 ITPR1 抗体)/Brd8 (显示 BRD8 抗体) is essential to allow fat cell differentiation
In mouse trophoblast stem cells, the amount of histone H2A.Z at promoters decreased during S phase, coinciding with homotypic (H2A.Z-H2A.Z) nucleosomes flanking the TSS (显示 RPL38 抗体) becoming heterotypic (H2A.Z-H2A).
It was shown that Ring1B (显示 RNF2 抗体) interacted with multiple complexes in embryonic stem cells. Although H2A.Z co-localized with Eed (显示 EED 抗体), Ring1B (显示 RNF2 抗体) and CpG islands in chromatin, H2A.Z still blanketed polycomb (显示 CBX2 抗体) target loci in the absence of Suz12, Eed (显示 EED 抗体), or Ring1B (显示 RNF2 抗体).
Studies indicate that the unique chromatin landscape also includes a second histone variant, H2A.Z.
Depletion of H2A.Z by RNA interference perturbs Xenopus laevis development at gastrulation leading to embryos with malformed, shortened trunks.
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene encodes a replication-independent member of the histone H2A family that is distinct from other members of the family. Studies in mice have shown that this particular histone is required for embryonic development and indicate that lack of functional histone H2A leads to embryonic lethality.
, histone H2A.Z
, H2A histone family, member Z
, H2A histone family member V
, H2A histone family, member V
, histone H2A.V
, histone H2A.Z-like
, histone H2A.Zl2
, histone H2AF