(Heart and Neural Crest Derivatives Expressed 1 (HAND1))
The protein encoded by this gene belongs to the basic helix-loop-helix family of transcription factors. This gene product is one of two closely related family members, the HAND proteins, which are asymmetrically expressed in the developing ventricular chambers and play an essential role in cardiac morphogenesis. Working in a complementary fashion, they function in the formation of the right ventricle and aortic arch arteries, implicating them as mediators of congenital heart disease. In addition, it has been suggested that this transcription factor may be required for early trophoblast differentiation. [provided by RefSeq, Jul 2008].
Lu, Du, Shan, Wang, Ma, Dong: "Haploinsufficiency of Hand1 improves mice survival after acute myocardial infarction through preventing cardiac rupture." in: Biochemical and biophysical research communications, Vol. 478, Issue 4, pp. 1726-31, (2016) (PubMed).
Zhang, Chen, Ye, Wang, Wang, Yuan, Lin, Wu, Zhang, Lin: "Wnt signaling promotes hindgut fate commitment through regulating multi-lineage genes during hESC differentiation." in: Cellular signalling, Vol. 29, pp. 12-22, (2016) (PubMed).
Lexer, Welch, Durphy, Rieseberg: "Natural selection for salt tolerance quantitative trait loci (QTLs) in wild sunflower hybrids: implications for the origin of Helianthus paradoxus, a diploid hybrid species." in: Molecular ecology, Vol. 12, Issue 5, pp. 1225-35, (2003) (PubMed).
Firulli, Howard, McDaid, McIlreavey, Dionne, Centonze, Cserjesi, Virshup, Firulli: "PKA, PKC, and the protein phosphatase 2A influence HAND factor function: a mechanism for tissue-specific transcriptional regulation." in: Molecular cell, Vol. 12, Issue 5, pp. 1225-37, (2003) (PubMed).
Dai, Cserjesi: "The basic helix-loop-helix factor, HAND2, functions as a transcriptional activator by binding to E-boxes as a heterodimer." in: The Journal of biological chemistry, Vol. 277, Issue 15, pp. 12604-12, (2002) (PubMed).