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CREBBP and p300 (显示 EP300 蛋白) may contribute to genome stability by fine-tuning the functions of DNA damage signaling and DNA repair factors, thereby expanding their role as tumor suppressors. (Review)
This review is focused on the different targets and functions of p300/CBP in physiological and pathological processes, including lipogenesis, lipid export, gluconeogenesis, and liver fibrosis, also provided some nutrients as the regulator of p300/CBP for nutritional therapeutic approaches to treat liver diseases.
provide evidence that both CREBBP and EP300 (显示 EP300 蛋白) are bona fide tumor suppressors that control MHCII expression and promote tumor immune control; mutational inactivation of CREBBP, but not of EP300 (显示 EP300 蛋白), has additional cell-intrinsic engraftment and growth-promoting effects
BRD, PHD (显示 PDC 蛋白), and ZZ domains interact with SUMO-1 (显示 SUMO1 蛋白) and Ubc9 (显示 UBE2I 蛋白), and function as an intramolecular E3 ligase for SUMOylation of the cell cycle regulatory domain 1; the BRD is essential for histone H3 (显示 HIST3H3 蛋白) acetylation
CREBBP Mutation is associated with Rubinstein-Taybi Syndrome and Medulloblastoma.
The recruitment of COASY (显示 COASY 蛋白) inhibits CBP-mediated TPX2 (显示 TPX2 蛋白) acetylation, promoting TPX2 (显示 TPX2 蛋白) degradation for mitotic exit.
GATA3 (显示 GATA3 蛋白) interacts with and is acetylated by the acetyltransferase CBP. The major acetylated site of GATA3 (显示 GATA3 蛋白) in lung adenocarcinoma cells is lysine 119.
The mechanism of CBP-CREB (显示 CREB1 蛋白) association via their pKID/KIX domains studied by molecular dynamics free energy simulations has been reported.
Our study demonstrated the association of low CREBBP expression with adverse clinical and biological features, poor prednisone response, high MRD levels and inferior outcomes in paediatric Chinese patients with ALL who were treated with the BCH (显示 CHN2 蛋白)- 2003 and CCLG- 2008 pro- tocols.
Knockdown of CREB (显示 CREB1 蛋白) suppressed the expression of matrix metallopeptidase (显示 ECEL1 蛋白) (MMP)2 (显示 MMP2 蛋白)/9.
this study elucidates the role of the aPKC-CBP pathway in modulating neurovascular remodeling and functional recovery following focal ischemic stroke.
Data (including data from studies in knockout and transgenic mice) suggest that Ep300 (显示 EP300 蛋白) and Crebbp are limiting cofactors for pancreatic islet development (including gene expression regulation and cell proliferation), and hence for postnatal glucose homeostasis, with some functional redundancy. (Ep300 (显示 EP300 蛋白) = E1A binding protein p300 (显示 EP300 蛋白); Crebbp = CREB binding protein)
Enhancer-priming by MLL3/MLL4 followed by enhancer-activation by CBP/p300 sequentially shape dynamic enhancer landscapes during cell differentiation
the aPKC-CBP pathway is a homeostatic compensatory mechanism that modulates hippocampal neurogenesis and memory in an age-dependent manner in response to reduced CREB (显示 CREB1 蛋白) activity.
Earlier loss of Crebbp is advantageous for lymphoid transformation and inform the cellular origins and subsequent evolution of lymphoid malignancies.
High CBP-P300 expression is associated with lymphoma.
This study provides evidence from transgenic mouse models that Crebbp deletion results in deficits in B-cell development and can cooperate with Bcl2 (显示 BCL2 蛋白) overexpression to promote B-cell lymphoma.
Data (including data from studies of hydrogen-deuterium exchange coupled to mass spectrometry in presence of denaturants) suggest that, for peptide fragments of human ACTR (显示 NCOA3 蛋白) and mouse Crebbp representing disordered interaction domains, exchange rates are changed dramatically by high concentrations of denaturants guanidinium chloride or urea. (ACTR (显示 NCOA3 蛋白) = activator of thyroid and retinoid receptor; Crebbp = CREB binding protein)
This gene is ubiquitously expressed and is involved in the transcriptional coactivation of many different transcription factors. First isolated as a nuclear protein that binds to cAMP-response element binding protein (CREB), this gene is now known to play critical roles in embryonic development, growth control, and homeostasis by coupling chromatin remodeling to transcription factor recognition. The protein encoded by this gene has intrinsic histone acetyltransferase activity and also acts as a scaffold to stabilize additional protein interactions with the transcription complex. This protein acetylates both histone and non-histone proteins. This protein shares regions of very high sequence similarity with protein p300 in its bromodomain, cysteine-histidine-rich regions, and histone acetyltransferase domain. Mutations in this gene cause Rubinstein-Taybi syndrome (RTS). Chromosomal translocations involving this gene have been associated with acute myeloid leukemia. Alternative splicing results in multiple transcript variants encoding different isoforms.
, CREB binding protein (Rubinstein-Taybi syndrome)