CBP Protein (AA 1081-1197) (His tag,DYKDDDDK Tag)
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- 抗原 See all CBP (CREBBP) 蛋白
- CBP (CREBBP) (CREB Binding Protein (CREBBP))
- 蛋白类型
- Recombinant
- 产品特性
- AA 1081-1197
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宿主
- 人
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资源
- 大肠杆菌（E. Coli）
- 标记
- This CBP protein is labelled with His tag,DYKDDDDK Tag.
- 应用范围
- Binding Studies (Bind), Screening Assay (ScA)
- 产品特性
- The peptide corresponding to amino acids 1081 - 1197 that contains the bromodomain sequences of CREBBP (accession number NM_004380.2) was expressed in E. coli and contains an N-terminal His tag and C-terminal FLAG tag with an observed molecular weight of 18.7 kDa. It shows binding specificity for acetylated H2BK85, H3K9/K14, H3K14, H3K36, H3K56, H3S10/K14/K18, H4K12, H4K20 and H4K44, as well as acetylated p53-K382 , MyoD-K99 and MyoD-K99/K102.
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- Discover our top product CREBBP 蛋白
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CREB Binding Protein (CREBBP) (AA 1081-1197) protein (His tag)
CREBBP 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 95 % as determined by SDS-PAGE WB, ELISA
CREB Binding Protein (CREBBP) (AA 951-1050) protein (GST tag)CREBBP 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AA, AP
CREB Binding Protein (CREBBP) proteinCREBBP 宿主: 小鼠 宿主: 大肠杆菌（E. Coli） Recombinant > 95 % WB, SDS
CREB Binding Protein (CREBBP) proteinCREBBP 宿主: 大鼠 宿主: 大肠杆菌（E. Coli） Recombinant > 95 % WB, SDS, ELISA, IP
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- 应用备注
- Recombinant CREBBP (1081-1197) is suitable for use in binding assays, inhibitor screening, and selectivity profiling.
- 限制
- 仅限研究用
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- 注意事项
- Avoid repeated freeze/thaw cycles and keep on ice when not in storage.
- 储存条件
- -80 °C
- 储存方法
- Recombinant proteins in solution are temperature sensitive and must be stored at -80°C to prevent degradation.
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- 抗原
- CBP (CREBBP) (CREB Binding Protein (CREBBP))
- 别名
- CREBBP (CREBBP 产品)
- 别名
- CBP Protein, KAT3A Protein, RSTS Protein, AW558298 Protein, CBP/p300 Protein, p300/CBP Protein, RTS Protein, cbp Protein, crebbp Protein, kat3a Protein, rsts Protein, hmm291030 Protein, Nejire Protein, CREB binding protein Protein, CREB binding protein L homeolog Protein, histone acetyltransferase p300 Protein, CREBBP Protein, Crebbp Protein, crebbp.L Protein, LOC100123220 Protein
- 背景
- CREB-binding protein (CREBBP) or CBP, is a protein known to play critical roles in embryonic development, growth control, and homeostasis by coupling chromatin remodeling to transcription factor recognition. CREBBP shares regions of very high sequence similarity with protein p300 in its bromodomain, cysteine-histidine-rich regions, and histone acetyltransferase domain. The CREBBP bromodomain recognizes acetylated histone lysine residues and functions as a 'reader' of these epigenetic histone marks to regulate chromatin structure and gene expression by linking associated proteins to the recognized acetylated nucleosomal targets. CREBBP has intrinsic histone acetyltransferase activity and also acts as a scaffold to stabilize additional protein interactions with the transcription complex. CREBBP acetylates histones as well as non-histone proteins, like NCOA3 coactivator. In addition, CREBBP binds specifically to phosphorylated CREB and enhances its transcriptional activity toward cAMP-responsive genes. CREBBP also has been shown to act as a coactivator of ALX1 in the presence of p300.
- 分子量
- 18.7 kDa
- 途径
- TCR Signaling, Interferon-gamma Pathway, Stem Cell Maintenance, Chromatin Binding, Regulation of Lipid Metabolism by PPARalpha
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