CBFA2T2 蛋白
(Core-binding Factor, Runt Domain, alpha Subunit 2, Translocated To, 2 (CBFA2T2))
In acute myeloid leukemia, especially in the M2 subtype, the t(8\;21)(q22\;q22) translocation is one of the most frequent karyotypic abnormalities. The translocation produces a chimeric gene made up of the 5'-region of the RUNX1 (AML1) gene fused to the 3'-region of the CBFA2T1 (MTG8) gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. The protein encoded by this gene binds to the AML1-MTG8 complex and may be important in promoting leukemogenesis. Several transcript variants are thought to exist for this gene, but the full-length natures of only three have been described. [provided by RefSeq, Jul 2008].
| Catalog no. | 产品 | 适用 | 宿主 / 克隆类型 | 应用 | 价格和交货时间 |
|---|---|---|---|---|---|
| CBFA2T2 Protein (AA 1-614) (GST tag) | 人 | 小麦胚 |
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| CBFA2T2 Protein (AA 31-239) (His tag) | 人 | 大肠杆菌（E. Coli） |
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| CBFA2T2 Protein (AA 1-604) (Strep Tag) | 人 | Cell-free protein synthesis (CFPS) |
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| CBFA2T2 Protein (AA 1-594) (Strep Tag) | 小鼠 | Cell-free protein synthesis (CFPS) |
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| CBFA2T2 Protein (Transcript Variant 4) (Myc-DYKDDDDK Tag) | 人 | HEK-293 Cells |
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Protein
- ELISA (ELISA: 所列应用)
- SDS (SDS-PAGE: 所列应用)
- WB (Western Blotting: 所列应用)
- 质量等级
- custom-made
- 宿主
- 人
- 宿主
- Cell-free protein synthesis (CFPS)
- 蛋白类型
- Recombinant
- 纯度
- approximately 70-80 % as determined by SDS PAGE, Western Blot and analytical SEC (HPLC).
Protein
- ELISA (ELISA: 所列应用)
- SDS (SDS-PAGE: 所列应用)
- WB (Western Blotting: 所列应用)
- 质量等级
- custom-made
- 宿主
- 小鼠
- 宿主
- Cell-free protein synthesis (CFPS)
- 蛋白类型
- Recombinant
- 纯度
- approximately 70-80 % as determined by SDS PAGE, Western Blot and analytical SEC (HPLC).
Protein
- WB (Western Blotting: 有验证图片)
- AbP (Antibody Production: 所列应用)
- STD (Standard: 所列应用)
- 宿主
- 人
- 宿主
- HEK-293 Cells
- 蛋白类型
- Recombinant
- 纯度
- > 80 % as determined by SDS-PAGE and Coomassie blue staining
Aliases for CBFA2T2 蛋白
CBFA2/RUNX1 translocation partner 2 (Cbfa2t2) 蛋白CBFA2/RUNX1 translocation partner 2 (CBFA2T2) 蛋白
core-binding factor, runt domain, alpha subunit 2, translocated to, 2 (human) (Cbfa2t2) 蛋白
CBFA2/RUNX1 translocation partner 2 L homeolog (cbfa2t2.L) 蛋白
A430091M07 蛋白
C330013D05Rik 蛋白
cbfa2t2-a 蛋白
Cbfa2t2h 蛋白
EHT 蛋白
MTGR1 蛋白
p85 蛋白
XETOR 蛋白
ZMYND3 蛋白
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