CBFA2T2 蛋白
(Core-binding Factor, Runt Domain, alpha Subunit 2, Translocated To, 2 (CBFA2T2))
In acute myeloid leukemia, especially in the M2 subtype, the t(8\;21)(q22\;q22) translocation is one of the most frequent karyotypic abnormalities. The translocation produces a chimeric gene made up of the 5'-region of the RUNX1 (AML1) gene fused to the 3'-region of the CBFA2T1 (MTG8) gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. The protein encoded by this gene binds to the AML1-MTG8 complex and may be important in promoting leukemogenesis. Several transcript variants are thought to exist for this gene, but the full-length natures of only three have been described. [provided by RefSeq, Jul 2008].
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custom-made
CBFA2T2
宿主: 小鼠
宿主: Cell-free protein synthesis (CFPS)
Recombinant
approximately 70-80 % as determined by SDS PAGE, Western Blot and analytical SEC (HPLC).
ELISA, WB, SDS
custom-made
CBFA2T2
宿主: 人
宿主: Cell-free protein synthesis (CFPS)
Recombinant
approximately 70-80 % as determined by SDS PAGE, Western Blot and analytical SEC (HPLC).
ELISA, WB, SDS
Aliases for CBFA2T2 蛋白
CBFA2/RUNX1 translocation partner 2 (Cbfa2t2) 蛋白CBFA2/RUNX1 translocation partner 2 (CBFA2T2) 蛋白
core-binding factor, runt domain, alpha subunit 2, translocated to, 2 (human) (Cbfa2t2) 蛋白
CBFA2/RUNX1 translocation partner 2 L homeolog (cbfa2t2.L) 蛋白
A430091M07 蛋白
C330013D05Rik 蛋白
cbfa2t2-a 蛋白
Cbfa2t2h 蛋白
EHT 蛋白
MTGR1 蛋白
p85 蛋白
XETOR 蛋白
ZMYND3 蛋白
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