SIGLEC8 抗体
(Sialic Acid Binding Ig-Like Lectin 8 (SIGLEC8))
Sialic acid-binding immunoglobulin (Ig)-like lectins, or SIGLECs (e.g., CD33 (MIM 159590)), are a family of type 1 transmembrane proteins each having a unique expression pattern, mostly in hemopoietic cells. SIGLEC8 is a member of the CD33-like subgroup of SIGLECs, which are localized to 19q13.3-q13.4 and have 2 conserved cytoplasmic tyrosine-based motifs: an immunoreceptor tyrosine-based inhibitory motif, or ITIM (see MIM 604964), and a motif homologous to one identified in signaling lymphocyte activation molecule (SLAM\\\\; MIM 603492) that mediates an association with SLAM-associated protein (SAP\\\\; MIM 300490) (summarized by Foussias et al., 2000 [PubMed 11095983]).[supplied by OMIM, May 2010].
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SIGLEC8 抗体 by Grade
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SIGLEC8 抗体 by 适用
Find SIGLEC8 抗体 for a variety of species such as anti-Human SIGLEC8, anti-Mouse SIGLEC8, anti-Rat SIGLEC8. The species listed below are among those available. Click on a link to go to the corresponding products.
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SIGLEC8 抗体 by 克隆形成能力
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SIGLEC8 抗体 by 克隆
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SIGLEC8 抗体 by 标记
Find SIGLEC8 抗体 with a specific conjugate such as PE, Biotin, APC. The conjugates listed below are among those available. Click on a link to go to the corresponding products.
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Latest Publications for our SIGLEC8 抗体
: "Siglec-8 antibody reduces eosinophils and mast cells in a transgenic mouse model of eosinophilic gastroenteritis." in: JCI insight, Vol. 4, Issue 19, (2019) (PubMed).: "Inhibition of FcepsilonRI-dependent mediator release and calcium flux from human mast cells by sialic acid-binding immunoglobulin-like lectin 8 engagement." in: The Journal of allergy and clinical immunology, Vol. 121, Issue 2, pp. 499-505.e1, (2008) (PubMed).
: "Intravenous immunoglobulin preparations contain anti-Siglec-8 autoantibodies." in: The Journal of allergy and clinical immunology, Vol. 119, Issue 4, pp. 1005-11, (2007) (PubMed).
: "Ligation of Siglec-8: a selective mechanism for induction of human eosinophil apoptosis." in: Blood, Vol. 101, Issue 12, pp. 5014-20, (2003) (PubMed).
: "Molecular characterization of a Siglec8 variant containing cytoplasmic tyrosine-based motifs, and mapping of the Siglec8 gene." in: Biochemical and biophysical research communications, Vol. 278, Issue 3, pp. 775-81, (2000) (PubMed).
: "Siglec-8. A novel eosinophil-specific member of the immunoglobulin superfamily." in: The Journal of biological chemistry, Vol. 275, Issue 2, pp. 861-6, (2000) (PubMed).
: "Identification of SAF-2, a novel siglec expressed on eosinophils, mast cells, and basophils." in: The Journal of allergy and clinical immunology, Vol. 105, Issue 6 Pt 1, pp. 1093-100, (2000) (PubMed).
Aliases for SIGLEC8 抗体
sialic acid binding Ig like lectin 8 (SIGLEC8) 抗体sialic acid-binding Ig-like lectin 8 (LOC506364) 抗体
SAF2 抗体
SIGLEC-8 抗体
SIGLEC8 抗体
SIGLEC8L 抗体
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