SIGLEC7 抗体
(Sialic Acid Binding Ig-Like Lectin 7 (SIGLEC7))
Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3- and alpha-2,6-linked sialic acid. Also binds disialogangliosides (disialogalactosyl globoside, disialyl lactotetraosylceramide and disialyl GalNAc lactotetraoslylceramide). The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. Mediates inhibition of natural killer cells cytotoxicity. May play a role in hemopoiesis. Inhibits differentiation of CD34+ cell precursors towards myelomonocytic cell lineage and proliferation of leukemic myeloid cells (in vitro).
recommended
SIGLEC7 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
recommended
recommended
SIGLEC7 抗体 by 适用
Find SIGLEC7 抗体 for a variety of species such as anti-Human SIGLEC7, anti-Mouse SIGLEC7, anti-Monkey SIGLEC7. The species listed below are among those available. Click on a link to go to the corresponding products.
SIGLEC7 抗体 by 抗体来源
Find SIGLEC7 抗体 with a specific 抗体来源. The 抗体来源 listed below are among those available. Click on a link to go to the corresponding products.
SIGLEC7 抗体 by 克隆形成能力
Find available monoclonal or polyclonal SIGLEC7 抗体. Click on a link to go to the corresponding products.
SIGLEC7 抗体 by 克隆
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SIGLEC7 抗体 by 标记
Find SIGLEC7 抗体 with a specific conjugate such as FITC, Biotin, PE. The conjugates listed below are among those available. Click on a link to go to the corresponding products.
SIGLEC7 抗体 by Fragment
Find SIGLEC7 抗体 with a specific Fragment. The Fragment listed below are among those available. Click on a link to go to the corresponding products.
Popular SIGLEC7 抗体
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Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, ELISA, IHC, IF
Validations
- (4)
Cat. No.
ABIN7169566
Quantity
100 μg
Datasheet
Datasheet
Reactivity
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Application
WB, IHC, IP, ICC
Validations
- (3)
Cat. No.
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Quantity
100 μL
Datasheet
Datasheet
Reactivity
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Application
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Validations
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- (2)
Cat. No.
ABIN544596
Quantity
400 μL
Datasheet
Datasheet
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Application
FACS
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Cat. No.
ABIN2749127
Quantity
100 tests
Datasheet
Datasheet
Reactivity
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Application
WB, IHC (p), ICC, IF
Validations
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Cat. No.
ABIN2856478
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC, IP, ICC
Validations
- (2)
Cat. No.
ABIN7427762
Quantity
100 μL
Datasheet
Datasheet
Reactivity
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Application
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Cat. No.
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Quantity
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Datasheet
Reactivity
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Cat. No.
ABIN2749061
Quantity
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Datasheet
Datasheet
Reactivity
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Application
WB, IHC, ICC
Validations
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Cat. No.
ABIN1175022
Quantity
100 μL
Datasheet
Datasheet
Reactivity
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Application
WB, IHC (p)
Validations
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Cat. No.
ABIN388428
Quantity
400 μL
Datasheet
Datasheet
Reactivity
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Application
WB, ELISA, IHC
Validations
- (3)
Cat. No.
ABIN3032556
Quantity
0.4 mL
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA, IHC
Validations
- (3)
Cat. No.
ABIN3032557
Quantity
0.4 mL
Datasheet
Datasheet
Reactivity
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Application
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Validations
- (1)
Cat. No.
ABIN5587916
Quantity
50 μg
Datasheet
Datasheet
Reactivity
Cow, Dog, Human
Application
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Validations
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Cat. No.
ABIN6738299
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB
Validations
- (1)
Cat. No.
ABIN6738298
Quantity
100 μL
Datasheet
Datasheet
Latest Publications for our SIGLEC7 抗体
: "Siglec-7 restores β-cell function and survival and reduces inflammation in pancreatic islets from patients with diabetes." in: Scientific reports, Vol. 7, pp. 45319, (2017) (PubMed).: "Siglec-1 is a novel dendritic cell receptor that mediates HIV-1 trans-infection through recognition of viral membrane gangliosides." in: PLoS biology, Vol. 10, Issue 12, pp. e1001448, (2012) (PubMed).
: "Engagement of Siglec-7 receptor induces a pro-inflammatory response selectively in monocytes." in: PLoS ONE, Vol. 7, Issue 9, pp. e45821, (2012) (PubMed).
: "Siglecs facilitate HIV-1 infection of macrophages through adhesion with viral sialic acids." in: PLoS ONE, Vol. 6, Issue 9, pp. e24559, (2011) (PubMed).
: "Differences in the constitutive and SIV infection induced expression of Siglecs by hematopoietic cells from non-human primates." in: Cellular immunology, Vol. 250, Issue 1-2, pp. 91-104, (2008) (PubMed).
: "Sialic acid-binding immunoglobulin-like lectin 7 mediates selective recognition of sialylated glycans expressed on Campylobacter jejuni lipooligosaccharides." in: Infection and immunity, Vol. 74, Issue 7, pp. 4133-41, (2006) (PubMed).
: "High resolution crystal structures of Siglec-7. Insights into ligand specificity in the Siglec family." in: The Journal of biological chemistry, Vol. 278, Issue 5, pp. 3372-7, (2003) (PubMed).
: "Ganglioside GD3 expression on target cells can modulate NK cell cytotoxicity via siglec-7-dependent and -independent mechanisms." in: European journal of immunology, Vol. 33, Issue 6, pp. 1642-8, (2003) (PubMed).
Aliases for SIGLEC7 抗体
sialic acid-binding Ig-like lectin 7 (LOC468976) 抗体sialic acid binding Ig like lectin 7 (SIGLEC7) 抗体
AIRM1 抗体
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