NFKBIA 蛋白
-
- 抗原 See all NFKBIA 蛋白
- NFKBIA (Nuclear Factor of kappa Light Polypeptide Gene Enhancer in B-Cells Inhibitor, alpha (NFKBIA))
- 蛋白类型
- Recombinant
- 生物活性
- Active
-
宿主
- 人
-
资源
- 大肠杆菌(E. Coli)
- 原理
- Active Recombinant Human IkB-alpha/NFKBIA Protein
- 序列
- FQAAERPQEW AMEGPRDGLK KERLLDDRHD SGLDSMKDEE YEQMVKELQE IRLEPQEVPR GSEPWKQQLT EDGDSFLHLA IIHEEKALTM EVIRQVKGDL AFLNFQNNLQ QTPLHLAVIT NQPEIAEALL GAGCDPELRD FRGNTPLHLA CEQGCLASVG VLTQSCTTPH LHSILKATNY NGHTCLHLAS IHGYLGIVEL LVSLGADVNA QEPCNGRTAL HLAVDLQNPD LVSLLLKCGA DVNRVTYQGY SPYQLTWGRP STRIQQQLGQ LTLENLQMLP ESEDEESYDT ESEFTEFTED ELPYDDCVFG GQRLTL
- 特异性
- Phe2-Leu317
- 纯度
- > 90 % by SDS-PAGE.
- 过滤
- 0.22 μm filtered
- 内毒素水平
- < 1.0 EU/μg of the protein by LAL method.
- Biological Activity Comment
- Measured by its binding ability in a functional ELISA. Immobilized Human IkB-alpha Protein at 2 μg/mL (100 μL/well) can bind IκBα Rabbit mAb with a linear range of 0.195-0.64 ng/mL.
- Top Product
- Discover our top product NFKBIA 蛋白
-
-
- 限制
- 仅限研究用
-
- 状态
- Lyophilized
- 溶解方式
- Centrifuge the vial before opening. Reconstitute to a concentration of 0.1-0.5 mg/mL in sterile distilled water. Avoid votex or vigorously pipetting the protein. For long term storage, it is recommended to add a carrier protein or stablizer (e.g. 0.1 % BSA, 5 % HSA, 10 % FBS or 5 % Trehalose), and aliquot the reconstituted protein solution to minimize free-thaw cycles.
- 缓冲液
- Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4.
- 储存条件
- -20 °C,-80 °C
- 储存方法
-
Store the lyophilized protein at -20°C to -80 °C for long term.
After reconstitution, the protein solution is stable at -20 °C for 3 months, at 2-8 °C for up to 1 week.
-
- 抗原
- NFKBIA (Nuclear Factor of kappa Light Polypeptide Gene Enhancer in B-Cells Inhibitor, alpha (NFKBIA))
- 别名
- IkB-alpha/NFKBIA (NFKBIA 产品)
- 别名
- IKBA Protein, MAD-3 Protein, NFKBI Protein, AI462015 Protein, Nfkbi Protein, RL/IF-1 Protein, ECI-6/IKBA Protein, NFKBIA Protein, ikbaB Protein, wu:fb81f08 Protein, zgc:56666 Protein, zgc:77616 Protein, ikbaA Protein, wu:fj16a07 Protein, zgc:85769 Protein, NFKB inhibitor alpha Protein, nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha Protein, nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha b Protein, nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha a Protein, NFKBIA Protein, Nfkbia Protein, nfkbiab Protein, nfkbiaa Protein
- 背景
-
Description: This protein is a member of the NF-kappa-B inhibitor family, which contain multiple ankrin repeat domains. The protein is interacts with REL dimers to inhibit NF-kappa-B/REL complexes which are involved in inflammatory responses. The protein moves between the cytoplasm and the nucleus via a nuclear localization signal and CRM1-mediated nuclear export. Mutations in this gene have been found in ectodermal dysplasia anhidrotic with T-cell immunodeficiency autosomal dominant disease.
Name: IKBA, MAD-3, NFKBI,NFKBIA,MAD-3,NFKBI,IKB alpha,EDAID2, IKBA, NFKB inhibitor alpha
- 基因ID
- 4792
- UniProt
- P25963
- 途径
- NF-kappaB Signaling, TCR Signaling, TLR signaling, Fc-epsilon Receptor Signaling Pathway, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Maintenance of Protein Location, Hepatitis C, Protein targeting to Nucleus, Toll-Like Receptors Cascades, BCR Signaling
-