IFNAR1 Protein (His tag)
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- 抗原 See all IFNAR1 蛋白
- IFNAR1 (Interferon alpha/beta Receptor 1 (IFNAR1))
- 蛋白类型
- Recombinant
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宿主
- 人
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资源
- HEK-293 Cells
- 标记
- This IFNAR1 protein is labelled with His tag.
- 原理
- Recombinant Human IFNAR1 Protein
- 序列
- KNLKSPQKVE VDIIDDNFIL RWNRSDESVG NVTFSFDYQK TGMDNWIKLS GCQNITSTKC NFSSLKLNVY EEIKLRIRAE KENTSSWYEV DSFTPFRKAQ IGPPEVHLEA EDKAIVIHIS PGTKDSVMWA LDGLSFTYSL VIWKNSSGVE ERIENIYSRH KIYKLSPETT YCLKVKAALL TSWKIGVYSP VHCIKTTVEN ELPPPENIEV SVQNQNYVLK WDYTYANMTF QVQWLHAFLK RNPGNHLYKW KQIPDCENVK TTQCVFPQNV FQKGIYLLRV QASDGNNTSF WSEEIKFDTE IQAFLLPPVF NIRSLSDSFH IYIGAPKQSG NTPVIQDYPL IYEIIFWENT SNAERKIIEK KTDVTVPNLK PLTVYCVKAR AHTMDEKLNK SSVFSDAVCE KTKPGNTSK
- 特异性
- Lys28-Lys436
- 纯度
- > 95 % by SDS-PAGE.
- 过滤
- 0.22 μm filtered
- 内毒素水平
- <0.1EU/μg
- Top Product
- Discover our top product IFNAR1 蛋白
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Interferon alpha/beta Receptor 1 (IFNAR1) protein (His tag)
IFNAR1 宿主: 猕猴 宿主: 人细胞 Recombinant > 90 % as determined by reducing SDS-PAGE.
Interferon alpha/beta Receptor 1 (IFNAR1) (AA 1-557) protein (GST tag)IFNAR1 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Interferon alpha/beta Receptor 1 (IFNAR1) (AA 28-127) protein (GST tag)IFNAR1 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Interferon alpha/beta Receptor 1 (IFNAR1) (Active) protein (His tag)IFNAR1 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 96 % as determined by SDS-PAGE Active
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Centrifuge the vial before opening. Reconstitute to a concentration of 0.1-0.5 mg/mL in sterile distilled water. Avoid votex or vigorously pipetting the protein. For long term storage, it is recommended to add a carrier protein or stablizer (e.g. 0.1 % BSA, 5 % HSA, 10 % FBS or 5 % Trehalose), and aliquot the reconstituted protein solution to minimize free-thaw cycles.
- 缓冲液
- Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4.
- 储存条件
- -20 °C,-80 °C
- 储存方法
- Store the lyophilized protein at -20°C to -80°C for 12 months.|After reconstitution, the protein solution is stable at -20°C for 3 months, at 2-8°C for up to 1 week.
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- 抗原
- IFNAR1 (Interferon alpha/beta Receptor 1 (IFNAR1))
- 别名
- IFNAR1 (IFNAR1 产品)
- 别名
- ifnar1 Protein, IFNAR1 Protein, CD118 Protein, Ifar Protein, Ifnar Protein, Ifrc Protein, Infar Protein, AVP Protein, IFN-alpha-REC Protein, IFNAR Protein, IFNBR Protein, IFRC Protein, IFN-R-1 Protein, interferon alpha and beta receptor subunit 1 Protein, interferon-alpha/beta receptor alpha chain-like Protein, interferon (alpha and beta) receptor 1 Protein, interferon alpha/beta receptor 1 Protein, IFNAR1 Protein, ifnar1 Protein, Ifnar1 Protein, LOC609830 Protein
- 背景
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Description: Interferon-alpha/beta receptor alpha chain (IFNAR1) is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta. Binding and activation of the receptor stimulate Janus protein kinases, which in turn phosphorylate several proteins, including STAT1 and STAT2. The encoded protein also functions as an antiviral factor. Tyk2 slows down IFNAR1 degradation and that this is due, at least in part, to inhibition of IFNAR1 endocytosis. Mutant versions of IFNAR1, in which Tyr466 is changed to phenylalanine, can act in a dominant-negative manner to inhibit phosphorylation of STAT2. These observations are consistent with a model in which IFNAR1 mediates the interaction between JAK kinases and the STAT transcription factors.
Name: AVP, IFN-alpha-REC, IFNAR, IFNBR, IFRC,IFNAR1,IFN-alpha-REC,IFNAR,IFNBR,IFRC
- 基因ID
- 3454
- UniProt
- P17181
- 途径
- JAK/STAT Signaling, Hepatitis C
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