IFNAR1 Protein (His tag)
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- 抗原 See all IFNAR1 蛋白
- IFNAR1 (Interferon alpha/beta Receptor 1 (IFNAR1))
- 蛋白类型
- Recombinant
- 生物活性
- Active
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宿主
- 小鼠
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资源
- HEK-293 Cells
- 标记
- This IFNAR1 protein is labelled with His tag.
- 原理
- Recombinant Mouse IFNAR1/IFNAR Protein (His Tag)(Active)
- 序列
- Met 1-Thr 429
- 产品特性
- A DNA sequence encoding the extracellular domain of mouse IFNAR1 (NP_034638.2) extracellular domain (Met 1-Thr 429) was expressed, with a polyhistidine tag at the C-terminus.
- 纯度
- > 96 % as determined by SDS-PAGE
- 内毒素水平
- < 1.0 EU per μg of the protein as determined by the LAL method.
- Biological Activity Comment
- Measured by its ability to inhibit mIFNB1-mediated protection of L929 mouse fibroblast cells infected with vesicular stomatitis virus (VSV) to viral lysis.The ED50 for this effect is typically 0.2-1μg/mL.
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- Discover our top product IFNAR1 蛋白
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Interferon alpha/beta Receptor 1 (IFNAR1) protein (His tag)
IFNAR1 宿主: 小鼠 宿主: 大肠杆菌（E. Coli） Recombinant >85 % as determined by reducing SDS-PAGE.
Interferon alpha/beta Receptor 1 (IFNAR1) protein (His tag)IFNAR1 宿主: 猕猴 宿主: 人细胞 Recombinant > 90 % as determined by reducing SDS-PAGE.
Interferon alpha/beta Receptor 1 (IFNAR1) (AA 1-557) protein (GST tag)IFNAR1 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Interferon alpha/beta Receptor 1 (IFNAR1) (AA 28-127) protein (GST tag)IFNAR1 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Interferon alpha/beta Receptor 1 (IFNAR1) (AA 28-436) protein (His tag)Crystallography grade IFNAR1 宿主: 人 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, WB, ELISA, Crys
Interferon alpha/beta Receptor 1 (IFNAR1) (AA 27-429) protein (His tag)Crystallography grade IFNAR1 宿主: 小鼠 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, WB, ELISA, Crys
Interferon alpha/beta Receptor 1 (IFNAR1) (AA 450-590) protein (His tag)Crystallography grade IFNAR1 宿主: 小鼠 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, WB, ELISA, Crys
Interferon alpha/beta Receptor 1 (IFNAR1) (AA 28-557) protein (rho-1D4 tag)Crystallography grade IFNAR1 宿主: 人 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, WB, ELISA, Crys
Interferon alpha/beta Receptor 1 (IFNAR1) (AA 27-590) protein (rho-1D4 tag)Crystallography grade IFNAR1 宿主: 小鼠 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, WB, ELISA, Crys
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Please refer to the printed manual for detailed information.
- 缓冲液
- Lyophilized from sterile PBS, pH 7.4
- 储存条件
- 4 °C,-20 °C,-80 °C
- 储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- 抗原
- IFNAR1 (Interferon alpha/beta Receptor 1 (IFNAR1))
- 别名
- IFNAR1/IFNAR (IFNAR1 产品)
- 别名
- ifnar1 Protein, IFNAR1 Protein, CD118 Protein, Ifar Protein, Ifnar Protein, Ifrc Protein, Infar Protein, AVP Protein, IFN-alpha-REC Protein, IFNAR Protein, IFNBR Protein, IFRC Protein, IFN-R-1 Protein, interferon alpha and beta receptor subunit 1 Protein, interferon-alpha/beta receptor alpha chain-like Protein, interferon (alpha and beta) receptor 1 Protein, interferon alpha/beta receptor 1 Protein, IFNAR1 Protein, ifnar1 Protein, Ifnar1 Protein, LOC609830 Protein
- 背景
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Background: Interferon-alpha/beta receptor alpha chain (IFNAR1) is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta. Binding and activation of the receptor stimulates Janus protein kinases, which in turn phosphorylate several proteins, including STAT1 and STAT2. The encoded protein also functions as an antiviral factor. Tyk2 slows down IFNAR1 degradation and that this is due, at least in part, to inhibition of IFNAR1 endocytosis. Mutant versions of IFNAR1, in which Tyr466 is changed to phenylalanine, can act in a dominant negative manner to inhibit phosphorylation of STAT2. These observations are consistent with a model in which IFNAR1 mediates the interaction between JAK kinases and the STAT transcription factors.
Synonym: CD118,Ifar,Ifnar,Ifrc,Infar
- 分子量
- 47 kDa
- NCBI登录号
- NP_034638
- 途径
- JAK/STAT Signaling, Hepatitis C
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