LAMP1 Protein (His tag)
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- 抗原 See all LAMP1 蛋白
- LAMP1 (Lysosomal-Associated Membrane Protein 1 (LAMP1))
- 蛋白类型
- Recombinant
- 生物活性
- Active
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宿主
- 人
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资源
- HEK-293 Cells
- 标记
- This LAMP1 protein is labelled with His tag.
- 原理
- Recombinant Human LAMP1/CD107a Protein (His Tag)(Active)
- 序列
- Met 1-Met 382
- 产品特性
- A DNA sequence encoding the human LAMP1 (NP_005552.3) (Met 1-Met 382) was expressed, with a polyhistidine tag at the C-terminus.
- 纯度
- > 95 % as determined by reducing SDS-PAGE.
- 内毒素水平
- < 1.0 EU per μg as determined by the LAL method.
- Biological Activity Comment
- Measured by its ability to bind biotinylated recombinant human Galectin-3 in a functional ELISA.
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- Discover our top product LAMP1 蛋白
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Lysosomal-Associated Membrane Protein 1 (LAMP1) protein (His tag)
LAMP1 宿主: 小鼠 宿主: 人细胞 Recombinant > 95 % as determined by reducing SDS-PAGE.
Lysosomal-Associated Membrane Protein 1 (LAMP1) (AA 294-381) protein (His-IF2DI Tag)LAMP1 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 95 % by SDS-PAGE gel analyses WB, ELISA
Lysosomal-Associated Membrane Protein 1 (LAMP1) protein (Fc Tag)LAMP1 宿主: 大鼠 宿主: HEK-293 Cells Recombinant > 92 % as determined by SDS-PAGE
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Please refer to the printed manual for detailed information.
- 缓冲液
- Lyophilized from sterile PBS, pH 7.4
- 储存条件
- 4 °C,-20 °C,-80 °C
- 储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- 抗原
- LAMP1 (Lysosomal-Associated Membrane Protein 1 (LAMP1))
- 别名
- LAMP1/CD107a (LAMP1 产品)
- 别名
- CD107a Protein, LAMPA Protein, LGP120 Protein, AI196048 Protein, Lamp-1 Protein, LEP100 Protein, LAMP-1 Protein, LGP-A Protein, Lgpa Protein, Lysosome-associated membrane protein 1 Protein, cd107a Protein, lamp-1 Protein, lamp1 Protein, lampa Protein, lgp120 Protein, rexp76 Protein, lysosomal associated membrane protein 1 Protein, lysosomal-associated membrane protein 1 Protein, lysosomal-associated membrane protein 1 L homeolog Protein, LAMP1 Protein, Lamp1 Protein, lamp1.L Protein
- 背景
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Background: Lysosome-associated membrane glycoprotein 1, also known as CD107 antigen-like family member A, CD107a, and LAMP1, is a single-pass type I membrane protein which belongs to the LAMP family. CD107a is expressed largely in the endosome-lysosome membranes of cells, but is also found on the plasma membrane (1-2 % of total LAMP1). LAMP1 has been implicated in a variety of cellular functions, including cancer metastasis. It has been proposed LAMP1 serves as a therapeutic agent for some cancers, as well as a marker for lysosomal storage disorders and different cell types such as cytotoxic T cells. LAMP2, also known as CD107b, may also play a role in tumor cell metastasis and functions in the protection, maintenance, and adhesion of the lysosome. Cell surface LAMP1 and LAMP2 have been shown to promote adhesion of human peripheral blood mononuclear cells (PBMC) to vascular endothelium, therefore they are possibly involved in the adhesion of PBMCs to the site of inflammation. LAMP-1 is a glycoprotein highly expressed in lysosomal membranes. The present study was initiated to test LAMP-1 mRNA and protein levels in post mortem frontal cortex (area 8) of Alzheimer's disease (AD) stages I-IIA/B and stages V-VIC of Braak and Braak, compared with age-matched controls. LAMP-1 occurred in microglia and multinucleated giant cells in one AD case in whom amyloid burden was cleared following betaA-peptide immunization. In addition, LAMP-1 has been suggested to be a cell surface receptor for a specific amelogenin isoform, leucine-rich amelogenin peptide or LRAP. LAMP-1 can serve as a cell surface binding site for amelogenin on dental follicle cells and cementoblasts.
Synonym: Lysosome-Associated Membrane Glycoprotein 1, LAMP-1, Lysosome-Associated Membrane Protein 1, CD107 Antigen-Like Family Member A, CD107a, LAMP1,CD107a,LAMPA,LGP120
- 分子量
- 39.8 kDa
- NCBI登录号
- NP_005552
- 途径
- Autophagy
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