LAMP1 Protein (His tag)
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- 抗原 See all LAMP1 蛋白
- LAMP1 (Lysosomal-Associated Membrane Protein 1 (LAMP1))
- 蛋白类型
- Recombinant
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宿主
- 小鼠
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资源
- 人细胞
- 标记
- This LAMP1 protein is labelled with His tag.
- 原理
- Recombinant Mouse LAMP1/CD107a Protein (His Tag)
- 序列
- Leu25-Asn370
- 产品特性
- Recombinant Mouse LAMP1 is produced by our Mammalian expression system and the target gene encoding Leu25-Asn370 is expressed with a 6His tag at the C-terminus.
- 纯度
- > 95 % as determined by reducing SDS-PAGE.
- 内毒素水平
- < 1.0 EU per μg as determined by the LAL method.
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Lysosomal-Associated Membrane Protein 1 (LAMP1) (AA 294-381) protein (His-IF2DI Tag)
LAMP1 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 95 % by SDS-PAGE gel analyses WB, ELISA
Lysosomal-Associated Membrane Protein 1 (LAMP1) protein (Fc Tag)LAMP1 宿主: 大鼠 宿主: HEK-293 Cells Recombinant > 92 % as determined by SDS-PAGE
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Please refer to the printed manual for detailed information.
- 缓冲液
- Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
- 储存条件
- 4 °C,-20 °C,-80 °C
- 储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- 抗原
- LAMP1 (Lysosomal-Associated Membrane Protein 1 (LAMP1))
- 别名
- LAMP1/CD107a (LAMP1 产品)
- 别名
- CD107a Protein, LAMPA Protein, LGP120 Protein, AI196048 Protein, Lamp-1 Protein, LEP100 Protein, LAMP-1 Protein, LGP-A Protein, Lgpa Protein, Lysosome-associated membrane protein 1 Protein, cd107a Protein, lamp-1 Protein, lamp1 Protein, lampa Protein, lgp120 Protein, rexp76 Protein, lysosomal associated membrane protein 1 Protein, lysosomal-associated membrane protein 1 Protein, lysosomal-associated membrane protein 1 L homeolog Protein, LAMP1 Protein, Lamp1 Protein, lamp1.L Protein
- 背景
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Background: Lysosomal associated membrane protein 1 (LAMP1) is an approximately 120 kDa transmembrane glycoprotein that is a major protein component of lysosomal membranes. Mature mouse LAMP1 consists of a 346 amino acid (aa) intralumenal domain (ECD), a 24 aa transmembrane segment, and a 12 aa cytoplasmic tail. Its lumenal domain is organized into two heavily N-glycosylated regions separated by a Ser/Pro-rich linker that carries a minor amount of O-linked glycosylation. Within the lumenal domain, mouse LAMP1 shares approximately 64 % and 82 % aa sequence identity with human and rat LAMP1, respectively. The sorting of LAMP1 to lysosomes relies on a tyrosine motif in the cytoplasmic tail. In cytotoxic T cells and mast cells, LAMP1 is expressed in the membranes of intracellular granules that contain effector molecules such as perforin, granzymes, eicosanoids, and histamine. A glycoform of LAMP1 known as M150 is expressed on the surface of activated macrophages where it promotes T cell co-stimulation and a Th1 biased immune response. Exposure of epithelial cells to pathogenic Neisseria bacteria induces the redistribution of LAMP1 to the cell surface where it can be cleaved by the Neisseria IgA1 protease.
Synonym: Lysosome-associated membrane glycoprotein 1, LAMP-1, Lysosome-associated membrane protein 1, 120 kDa lysosomal membrane glycoprotein, CD107 antigen-like family member A, LGP-120, Lysosomal membrane glycoprotein A, LGP-A, P2B, CD107a
- 分子量
- 38.6 kDa
- UniProt
- P11438
- 途径
- Autophagy
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